Prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital

Gastroenteritis is one of the leading cause of illnesses through the world, especially in developing countries.Salmonella and Shigella infections are considered as the main public health problems in children. The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salm...

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Veröffentlicht in:Microbial pathogenesis 2017-08, Vol.109, p.45-48
Hauptverfasser: Mahmoudi, Shima, Pourakbari, Babak, Moradzadeh, Mina, Eshaghi, Hamid, Ramezani, Amitis, Haghi Ashtiani, Mohammad Taghi, Keshavarz Valian, Sepideh, Mamishi, Setareh
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container_start_page 45
container_title Microbial pathogenesis
container_volume 109
creator Mahmoudi, Shima
Pourakbari, Babak
Moradzadeh, Mina
Eshaghi, Hamid
Ramezani, Amitis
Haghi Ashtiani, Mohammad Taghi
Keshavarz Valian, Sepideh
Mamishi, Setareh
description Gastroenteritis is one of the leading cause of illnesses through the world, especially in developing countries.Salmonella and Shigella infections are considered as the main public health problems in children. The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital. During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected. In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates. Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic. In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended. •Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respe
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The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital. During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected. In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates. Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic. In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended. •Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2017.05.023</identifier><identifier>PMID: 28526638</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Anti-Infective Agents - pharmacology ; Antimicrobial resistance ; Bacterial gastroenteritis ; Cefotaxime - pharmacology ; Child ; Child, Preschool ; Children ; Diarrhea - etiology ; Diarrhea - microbiology ; Drug Resistance, Multiple, Bacterial ; Dysentery, Bacillary - epidemiology ; Dysentery, Bacillary - microbiology ; Escherichia coli - drug effects ; Escherichia coli - isolation &amp; purification ; Escherichia coli - pathogenicity ; Feces - microbiology ; Female ; Gastroenteritis - epidemiology ; Gastroenteritis - microbiology ; Hospitals ; Humans ; Infant ; Iran - epidemiology ; Male ; Microbial Sensitivity Tests - methods ; Nalidixic Acid - pharmacology ; Prevalence ; Retrospective Studies ; Salmonella - drug effects ; Salmonella - isolation &amp; purification ; Salmonella - pathogenicity ; Salmonella Infections - epidemiology ; Salmonella Infections - microbiology ; Serogroup ; Shigella - drug effects ; Shigella - isolation &amp; purification ; Shigella - pathogenicity</subject><ispartof>Microbial pathogenesis, 2017-08, Vol.109, p.45-48</ispartof><rights>2017</rights><rights>Copyright © 2017. 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The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital. During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected. In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates. Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic. In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended. •Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.</description><subject>Adolescent</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antimicrobial resistance</subject><subject>Bacterial gastroenteritis</subject><subject>Cefotaxime - pharmacology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Diarrhea - etiology</subject><subject>Diarrhea - microbiology</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Dysentery, Bacillary - epidemiology</subject><subject>Dysentery, Bacillary - microbiology</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - isolation &amp; 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Pourakbari, Babak ; Moradzadeh, Mina ; Eshaghi, Hamid ; Ramezani, Amitis ; Haghi Ashtiani, Mohammad Taghi ; Keshavarz Valian, Sepideh ; Mamishi, Setareh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-655547d448c41b438e5268c71093129579e58e4ca30beea7543e03c12907f7453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antimicrobial resistance</topic><topic>Bacterial gastroenteritis</topic><topic>Cefotaxime - pharmacology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Diarrhea - etiology</topic><topic>Diarrhea - microbiology</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Dysentery, Bacillary - epidemiology</topic><topic>Dysentery, Bacillary - microbiology</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - isolation &amp; 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The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital. During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected. In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates. Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic. In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended. •Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28526638</pmid><doi>10.1016/j.micpath.2017.05.023</doi><tpages>4</tpages></addata></record>
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subjects Adolescent
Anti-Infective Agents - pharmacology
Antimicrobial resistance
Bacterial gastroenteritis
Cefotaxime - pharmacology
Child
Child, Preschool
Children
Diarrhea - etiology
Diarrhea - microbiology
Drug Resistance, Multiple, Bacterial
Dysentery, Bacillary - epidemiology
Dysentery, Bacillary - microbiology
Escherichia coli - drug effects
Escherichia coli - isolation & purification
Escherichia coli - pathogenicity
Feces - microbiology
Female
Gastroenteritis - epidemiology
Gastroenteritis - microbiology
Hospitals
Humans
Infant
Iran - epidemiology
Male
Microbial Sensitivity Tests - methods
Nalidixic Acid - pharmacology
Prevalence
Retrospective Studies
Salmonella - drug effects
Salmonella - isolation & purification
Salmonella - pathogenicity
Salmonella Infections - epidemiology
Salmonella Infections - microbiology
Serogroup
Shigella - drug effects
Shigella - isolation & purification
Shigella - pathogenicity
title Prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital
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