Prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital
Gastroenteritis is one of the leading cause of illnesses through the world, especially in developing countries.Salmonella and Shigella infections are considered as the main public health problems in children. The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salm...
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Veröffentlicht in: | Microbial pathogenesis 2017-08, Vol.109, p.45-48 |
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creator | Mahmoudi, Shima Pourakbari, Babak Moradzadeh, Mina Eshaghi, Hamid Ramezani, Amitis Haghi Ashtiani, Mohammad Taghi Keshavarz Valian, Sepideh Mamishi, Setareh |
description | Gastroenteritis is one of the leading cause of illnesses through the world, especially in developing countries.Salmonella and Shigella infections are considered as the main public health problems in children. The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital.
During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected.
In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates.
Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.
In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended.
•Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respe |
doi_str_mv | 10.1016/j.micpath.2017.05.023 |
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During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected.
In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates.
Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.
In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended.
•Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2017.05.023</identifier><identifier>PMID: 28526638</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Anti-Infective Agents - pharmacology ; Antimicrobial resistance ; Bacterial gastroenteritis ; Cefotaxime - pharmacology ; Child ; Child, Preschool ; Children ; Diarrhea - etiology ; Diarrhea - microbiology ; Drug Resistance, Multiple, Bacterial ; Dysentery, Bacillary - epidemiology ; Dysentery, Bacillary - microbiology ; Escherichia coli - drug effects ; Escherichia coli - isolation & purification ; Escherichia coli - pathogenicity ; Feces - microbiology ; Female ; Gastroenteritis - epidemiology ; Gastroenteritis - microbiology ; Hospitals ; Humans ; Infant ; Iran - epidemiology ; Male ; Microbial Sensitivity Tests - methods ; Nalidixic Acid - pharmacology ; Prevalence ; Retrospective Studies ; Salmonella - drug effects ; Salmonella - isolation & purification ; Salmonella - pathogenicity ; Salmonella Infections - epidemiology ; Salmonella Infections - microbiology ; Serogroup ; Shigella - drug effects ; Shigella - isolation & purification ; Shigella - pathogenicity</subject><ispartof>Microbial pathogenesis, 2017-08, Vol.109, p.45-48</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-655547d448c41b438e5268c71093129579e58e4ca30beea7543e03c12907f7453</citedby><cites>FETCH-LOGICAL-c365t-655547d448c41b438e5268c71093129579e58e4ca30beea7543e03c12907f7453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2017.05.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28526638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmoudi, Shima</creatorcontrib><creatorcontrib>Pourakbari, Babak</creatorcontrib><creatorcontrib>Moradzadeh, Mina</creatorcontrib><creatorcontrib>Eshaghi, Hamid</creatorcontrib><creatorcontrib>Ramezani, Amitis</creatorcontrib><creatorcontrib>Haghi Ashtiani, Mohammad Taghi</creatorcontrib><creatorcontrib>Keshavarz Valian, Sepideh</creatorcontrib><creatorcontrib>Mamishi, Setareh</creatorcontrib><title>Prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>Gastroenteritis is one of the leading cause of illnesses through the world, especially in developing countries.Salmonella and Shigella infections are considered as the main public health problems in children. The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital.
During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected.
In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates.
Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.
In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended.
•Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.</description><subject>Adolescent</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antimicrobial resistance</subject><subject>Bacterial gastroenteritis</subject><subject>Cefotaxime - pharmacology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Diarrhea - etiology</subject><subject>Diarrhea - microbiology</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Dysentery, Bacillary - epidemiology</subject><subject>Dysentery, Bacillary - microbiology</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli - pathogenicity</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - microbiology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Nalidixic Acid - pharmacology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Salmonella - drug effects</subject><subject>Salmonella - isolation & purification</subject><subject>Salmonella - pathogenicity</subject><subject>Salmonella Infections - epidemiology</subject><subject>Salmonella Infections - microbiology</subject><subject>Serogroup</subject><subject>Shigella - drug effects</subject><subject>Shigella - isolation & purification</subject><subject>Shigella - pathogenicity</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCILoWfAPKRS8I4thPnhFAFbaVKIBXOluPMbmaVL2xvUX8Ffxlvd-HKwRpZ8968efMYeyugFCDqD_tyIr-6NJQViKYEXUIln7GNgLYuRAXmOduAMVWhQMAFexXjHgBaJduX7KIyuqpraTbs97eAD27E2SN3c59fojw4LB25kcdD9Lgm6mik9MiXLb9347TMOI7uCX4_0O7pE9e15C63dtwPNPYBZ_6L0sB3Lqaw4JwwUKLIac5EfhvcTLkG3GIIWWlY4krJja_Zi60bI74510v248vn71c3xd3X69urT3eFl7VORa21Vk2vlPFKdEoazIaMb7J7KapWNy1qg8o7CR2ia7SSCNLnFjTbRml5yd6f5q5h-XnAmOxE2Wu2MuNyiFa0AEZWopUZqk_QfJUY88Z2DTS58GgF2GMWdm_PWdhjFha0zVlk3ruzxKGbsP_H-nv8DPh4AmA2-kAYbPR0TKKngD7ZfqH_SPwB8fGfTA</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Mahmoudi, Shima</creator><creator>Pourakbari, Babak</creator><creator>Moradzadeh, Mina</creator><creator>Eshaghi, Hamid</creator><creator>Ramezani, Amitis</creator><creator>Haghi Ashtiani, Mohammad Taghi</creator><creator>Keshavarz Valian, Sepideh</creator><creator>Mamishi, Setareh</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital</title><author>Mahmoudi, Shima ; Pourakbari, Babak ; Moradzadeh, Mina ; Eshaghi, Hamid ; Ramezani, Amitis ; Haghi Ashtiani, Mohammad Taghi ; Keshavarz Valian, Sepideh ; Mamishi, Setareh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-655547d448c41b438e5268c71093129579e58e4ca30beea7543e03c12907f7453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antimicrobial resistance</topic><topic>Bacterial gastroenteritis</topic><topic>Cefotaxime - pharmacology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Diarrhea - etiology</topic><topic>Diarrhea - microbiology</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Dysentery, Bacillary - epidemiology</topic><topic>Dysentery, Bacillary - microbiology</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli - pathogenicity</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastroenteritis - epidemiology</topic><topic>Gastroenteritis - microbiology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Nalidixic Acid - pharmacology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Salmonella - drug effects</topic><topic>Salmonella - isolation & purification</topic><topic>Salmonella - pathogenicity</topic><topic>Salmonella Infections - epidemiology</topic><topic>Salmonella Infections - microbiology</topic><topic>Serogroup</topic><topic>Shigella - drug effects</topic><topic>Shigella - isolation & purification</topic><topic>Shigella - pathogenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahmoudi, Shima</creatorcontrib><creatorcontrib>Pourakbari, Babak</creatorcontrib><creatorcontrib>Moradzadeh, Mina</creatorcontrib><creatorcontrib>Eshaghi, Hamid</creatorcontrib><creatorcontrib>Ramezani, Amitis</creatorcontrib><creatorcontrib>Haghi Ashtiani, Mohammad Taghi</creatorcontrib><creatorcontrib>Keshavarz Valian, Sepideh</creatorcontrib><creatorcontrib>Mamishi, Setareh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmoudi, Shima</au><au>Pourakbari, Babak</au><au>Moradzadeh, Mina</au><au>Eshaghi, Hamid</au><au>Ramezani, Amitis</au><au>Haghi Ashtiani, Mohammad Taghi</au><au>Keshavarz Valian, Sepideh</au><au>Mamishi, Setareh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2017-08</date><risdate>2017</risdate><volume>109</volume><spage>45</spage><epage>48</epage><pages>45-48</pages><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>Gastroenteritis is one of the leading cause of illnesses through the world, especially in developing countries.Salmonella and Shigella infections are considered as the main public health problems in children. The aim of this study was to detect the prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital.
During April 2013 to April 2014, all medical records of children with gastroenteritis admitted to a pediatric medical center were evaluated. Positive stool cultures of children were evaluated and frequency of Salmonella and Shigella spp. and their antimicrobial susceptibility were detected.
In this study, 676 patients with the mean age of 24.94 months were enrolled. Eighty-eight (42%) Salmonella spp., 85 (40%) Shigella spp., 33 (16%) E. coli and 5(2%) candida albicans were isolated from 211 positive stool cultures. Among 85 Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively. Among 88 isolated Salmonella spp., 36 (41%) isolates were Salmonella Serogroup D, 26 (30%) were Salmonella Serogroup B, 20 (23%) isolates were Salmonella Serogroup C and 6 (7%) were other Salmonella spp. isolates.
Thirty-eight percent of Salmonella serogroup B were resistant to nalidixic acid, while higher frequency of nalidixic acid resistant was found in Salmonella serogroup C and Salmonella serogroup D. The higher frequency of ampicillin resistant was found in Shigella spp. than Salmonella spp. High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.
In conclusion, Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children. Since the prevalence of antibiotic resistance is increasing in recent years in Iran, further studies on the prevalence, antimicrobial susceptibility pattern and mechanisms of antibiotic resistance in these species is highly recommended.
•Shigella and Salmonella serogroups can be considered as important etiological agents of acute diarrhea in children.•Among Shigella spp. isolates, S. sonnei, S. flexneri and other Shigella spp. were isolated from 39 (46%) isolates, 36(42%) and 10(12%), respectively.•High frequency of cefotaxime resistant was seen in S. sonei and S. flexneri (77% and 56%, respectively), whereas more than 90% of Salmonella serogroup B, C and D were susceptible to this antibiotic.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28526638</pmid><doi>10.1016/j.micpath.2017.05.023</doi><tpages>4</tpages></addata></record> |
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subjects | Adolescent Anti-Infective Agents - pharmacology Antimicrobial resistance Bacterial gastroenteritis Cefotaxime - pharmacology Child Child, Preschool Children Diarrhea - etiology Diarrhea - microbiology Drug Resistance, Multiple, Bacterial Dysentery, Bacillary - epidemiology Dysentery, Bacillary - microbiology Escherichia coli - drug effects Escherichia coli - isolation & purification Escherichia coli - pathogenicity Feces - microbiology Female Gastroenteritis - epidemiology Gastroenteritis - microbiology Hospitals Humans Infant Iran - epidemiology Male Microbial Sensitivity Tests - methods Nalidixic Acid - pharmacology Prevalence Retrospective Studies Salmonella - drug effects Salmonella - isolation & purification Salmonella - pathogenicity Salmonella Infections - epidemiology Salmonella Infections - microbiology Serogroup Shigella - drug effects Shigella - isolation & purification Shigella - pathogenicity |
title | Prevalence and antimicrobial susceptibility of Salmonella and Shigella spp. among children with gastroenteritis in an Iranian referral hospital |
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