Oral contraceptive pills: Risky or protective in case of Trichinella spiralis infection?
Summary The aim of this study was to investigate how Trichinella spiralis infection can be affected by contraceptive pills in vivo. Methods included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs),...
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| Veröffentlicht in: | Parasite immunology 2017-08, Vol.39 (8), p.n/a |
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| creator | Hasby Saad, M. A. Radi, D. A. Hasby, E. A. |
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The aim of this study was to investigate how Trichinella spiralis infection can be affected by contraceptive pills in vivo. Methods included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs), infected receiving COCPs and infected receiving POPs. Parasite burden was measured; adult worm counts, gravidity, larvae and reproductive capacity index). Histopathological examination, immunohistochemical detection of C‐kit+ mast cells and Foxp3+ T‐reg. cells in intestinal sections, eosinophils muscle infiltration and CPK level were performed. Rats infected and receiving COCPs showed a significant increase in parasitic burden, and infected receiving POPs showed a significant reduction compared to infected only, with a significant increase in nongravid females (Mean total worms=964.40±55.9, 742±52.63, 686±31.68, larvae/g=5030±198.75, 2490±143.18 and 4126±152,91, respectively). Intestinal sections from infected receiving COCPs showed intact mucosa (though the high inflammatory cells infiltrate), and significant increase in C‐kit+ mast cells number and intensity (30.20±4.15 and 60.40±8.29), and Foxp3+ T‐reg. cells (10±1.58). Infected receiving POPs showed a significantly less CPK (5886±574.40) and eosinophilic muscle infiltration (58±13.51). Oestrogen‐containing pills established a favourable intestinal environment for Trichinella by enhancing Foxp+T‐reg. cells and stabilizing C‐kit+mast cells, while POPs gave a potential protection with less gravidity, larval burden and eosinophilic infiltrate. |
| doi_str_mv | 10.1111/pim.12444 |
| format | Article |
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The aim of this study was to investigate how Trichinella spiralis infection can be affected by contraceptive pills in vivo. Methods included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs), infected receiving COCPs and infected receiving POPs. Parasite burden was measured; adult worm counts, gravidity, larvae and reproductive capacity index). Histopathological examination, immunohistochemical detection of C‐kit+ mast cells and Foxp3+ T‐reg. cells in intestinal sections, eosinophils muscle infiltration and CPK level were performed. Rats infected and receiving COCPs showed a significant increase in parasitic burden, and infected receiving POPs showed a significant reduction compared to infected only, with a significant increase in nongravid females (Mean total worms=964.40±55.9, 742±52.63, 686±31.68, larvae/g=5030±198.75, 2490±143.18 and 4126±152,91, respectively). Intestinal sections from infected receiving COCPs showed intact mucosa (though the high inflammatory cells infiltrate), and significant increase in C‐kit+ mast cells number and intensity (30.20±4.15 and 60.40±8.29), and Foxp3+ T‐reg. cells (10±1.58). Infected receiving POPs showed a significantly less CPK (5886±574.40) and eosinophilic muscle infiltration (58±13.51). Oestrogen‐containing pills established a favourable intestinal environment for Trichinella by enhancing Foxp+T‐reg. cells and stabilizing C‐kit+mast cells, while POPs gave a potential protection with less gravidity, larval burden and eosinophilic infiltrate.</description><identifier>ISSN: 0141-9838</identifier><identifier>EISSN: 1365-3024</identifier><identifier>DOI: 10.1111/pim.12444</identifier><identifier>PMID: 28524239</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Animals ; c-Kit protein ; Contraceptives, Oral - adverse effects ; Contraceptives, Oral - therapeutic use ; CPK ; Estrogens ; Female ; Foxp3 ; Foxp3 protein ; Inflammation ; Inflammation - parasitology ; Intestine ; Intestines - drug effects ; Intestines - pathology ; Larva ; Larvae ; Leukocytes (eosinophilic) ; Mast Cells ; Mice ; Mucosa ; Oestrogen ; Progestin ; Rats ; Rats, Wistar ; Rodents ; Trichinella ; Trichinella spiralis ; Trichinellosis - parasitology ; Trichinellosis - pathology ; Trichinellosis - physiopathology ; Trichinellosis - prevention & control</subject><ispartof>Parasite immunology, 2017-08, Vol.39 (8), p.n/a</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3134-3c9898c6c1f03c4adcabf51610dcf199ae2218b7670dd20fd0d276106437af763</cites><orcidid>0000-0002-5972-5773</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpim.12444$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpim.12444$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28524239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasby Saad, M. A.</creatorcontrib><creatorcontrib>Radi, D. A.</creatorcontrib><creatorcontrib>Hasby, E. A.</creatorcontrib><title>Oral contraceptive pills: Risky or protective in case of Trichinella spiralis infection?</title><title>Parasite immunology</title><addtitle>Parasite Immunol</addtitle><description>Summary
The aim of this study was to investigate how Trichinella spiralis infection can be affected by contraceptive pills in vivo. Methods included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs), infected receiving COCPs and infected receiving POPs. Parasite burden was measured; adult worm counts, gravidity, larvae and reproductive capacity index). Histopathological examination, immunohistochemical detection of C‐kit+ mast cells and Foxp3+ T‐reg. cells in intestinal sections, eosinophils muscle infiltration and CPK level were performed. Rats infected and receiving COCPs showed a significant increase in parasitic burden, and infected receiving POPs showed a significant reduction compared to infected only, with a significant increase in nongravid females (Mean total worms=964.40±55.9, 742±52.63, 686±31.68, larvae/g=5030±198.75, 2490±143.18 and 4126±152,91, respectively). Intestinal sections from infected receiving COCPs showed intact mucosa (though the high inflammatory cells infiltrate), and significant increase in C‐kit+ mast cells number and intensity (30.20±4.15 and 60.40±8.29), and Foxp3+ T‐reg. cells (10±1.58). Infected receiving POPs showed a significantly less CPK (5886±574.40) and eosinophilic muscle infiltration (58±13.51). Oestrogen‐containing pills established a favourable intestinal environment for Trichinella by enhancing Foxp+T‐reg. cells and stabilizing C‐kit+mast cells, while POPs gave a potential protection with less gravidity, larval burden and eosinophilic infiltrate.</description><subject>Animals</subject><subject>c-Kit protein</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>Contraceptives, Oral - therapeutic use</subject><subject>CPK</subject><subject>Estrogens</subject><subject>Female</subject><subject>Foxp3</subject><subject>Foxp3 protein</subject><subject>Inflammation</subject><subject>Inflammation - parasitology</subject><subject>Intestine</subject><subject>Intestines - drug effects</subject><subject>Intestines - pathology</subject><subject>Larva</subject><subject>Larvae</subject><subject>Leukocytes (eosinophilic)</subject><subject>Mast Cells</subject><subject>Mice</subject><subject>Mucosa</subject><subject>Oestrogen</subject><subject>Progestin</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Trichinella</subject><subject>Trichinella spiralis</subject><subject>Trichinellosis - parasitology</subject><subject>Trichinellosis - pathology</subject><subject>Trichinellosis - physiopathology</subject><subject>Trichinellosis - prevention & control</subject><issn>0141-9838</issn><issn>1365-3024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1LwzAYBvAgipvTg_-ABLzooVveJG1TLyLDj8FkIhO8lSxNMLNra9Ip--_NPvQgmEsOz4-HlwehUyB9CG_Q2EUfKOd8D3WBJXHECOX7qEuAQ5QJJjroyPs5IcBowg5Rh4qYcsqyLnqdOFliVVetk0o3rf3UuLFl6a_ws_XvK1w73Li61WoT2Qor6TWuDZ46q95spctSYt_YUGN9yM1a1tX1MTowsvT6ZPf30Mvd7XT4EI0n96PhzThSDBiPmMpEJlSiwBCmuCyUnJkYEiCFMpBlUlMKYpYmKSkKSkxBCpqGNOEslSZNWA9dbHvDlR9L7dt8Yb1aX1XpeulzyAgRDASQQM__0Hm9dFW4LihKYiYCC-pyq5SrvXfa5I2zC-lWOZB8PXce5s43cwd7tmtczha6-JU_-wYw2IIvW-rV_0350-hxW_kNqt-InA</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Hasby Saad, M. A.</creator><creator>Radi, D. A.</creator><creator>Hasby, E. A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5972-5773</orcidid></search><sort><creationdate>201708</creationdate><title>Oral contraceptive pills: Risky or protective in case of Trichinella spiralis infection?</title><author>Hasby Saad, M. A. ; Radi, D. A. ; Hasby, E. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3134-3c9898c6c1f03c4adcabf51610dcf199ae2218b7670dd20fd0d276106437af763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>c-Kit protein</topic><topic>Contraceptives, Oral - adverse effects</topic><topic>Contraceptives, Oral - therapeutic use</topic><topic>CPK</topic><topic>Estrogens</topic><topic>Female</topic><topic>Foxp3</topic><topic>Foxp3 protein</topic><topic>Inflammation</topic><topic>Inflammation - parasitology</topic><topic>Intestine</topic><topic>Intestines - drug effects</topic><topic>Intestines - pathology</topic><topic>Larva</topic><topic>Larvae</topic><topic>Leukocytes (eosinophilic)</topic><topic>Mast Cells</topic><topic>Mice</topic><topic>Mucosa</topic><topic>Oestrogen</topic><topic>Progestin</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Trichinella</topic><topic>Trichinella spiralis</topic><topic>Trichinellosis - parasitology</topic><topic>Trichinellosis - pathology</topic><topic>Trichinellosis - physiopathology</topic><topic>Trichinellosis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasby Saad, M. A.</creatorcontrib><creatorcontrib>Radi, D. A.</creatorcontrib><creatorcontrib>Hasby, E. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Parasite immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasby Saad, M. A.</au><au>Radi, D. A.</au><au>Hasby, E. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral contraceptive pills: Risky or protective in case of Trichinella spiralis infection?</atitle><jtitle>Parasite immunology</jtitle><addtitle>Parasite Immunol</addtitle><date>2017-08</date><risdate>2017</risdate><volume>39</volume><issue>8</issue><epage>n/a</epage><issn>0141-9838</issn><eissn>1365-3024</eissn><abstract>Summary
The aim of this study was to investigate how Trichinella spiralis infection can be affected by contraceptive pills in vivo. Methods included six groups of female Wistar rats; healthy, Trichinella infected, receiving combined contraceptive pills (COCPs), receiving progestin only pills (POPs), infected receiving COCPs and infected receiving POPs. Parasite burden was measured; adult worm counts, gravidity, larvae and reproductive capacity index). Histopathological examination, immunohistochemical detection of C‐kit+ mast cells and Foxp3+ T‐reg. cells in intestinal sections, eosinophils muscle infiltration and CPK level were performed. Rats infected and receiving COCPs showed a significant increase in parasitic burden, and infected receiving POPs showed a significant reduction compared to infected only, with a significant increase in nongravid females (Mean total worms=964.40±55.9, 742±52.63, 686±31.68, larvae/g=5030±198.75, 2490±143.18 and 4126±152,91, respectively). Intestinal sections from infected receiving COCPs showed intact mucosa (though the high inflammatory cells infiltrate), and significant increase in C‐kit+ mast cells number and intensity (30.20±4.15 and 60.40±8.29), and Foxp3+ T‐reg. cells (10±1.58). Infected receiving POPs showed a significantly less CPK (5886±574.40) and eosinophilic muscle infiltration (58±13.51). Oestrogen‐containing pills established a favourable intestinal environment for Trichinella by enhancing Foxp+T‐reg. cells and stabilizing C‐kit+mast cells, while POPs gave a potential protection with less gravidity, larval burden and eosinophilic infiltrate.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28524239</pmid><doi>10.1111/pim.12444</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-5972-5773</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Animals c-Kit protein Contraceptives, Oral - adverse effects Contraceptives, Oral - therapeutic use CPK Estrogens Female Foxp3 Foxp3 protein Inflammation Inflammation - parasitology Intestine Intestines - drug effects Intestines - pathology Larva Larvae Leukocytes (eosinophilic) Mast Cells Mice Mucosa Oestrogen Progestin Rats Rats, Wistar Rodents Trichinella Trichinella spiralis Trichinellosis - parasitology Trichinellosis - pathology Trichinellosis - physiopathology Trichinellosis - prevention & control |
| title | Oral contraceptive pills: Risky or protective in case of Trichinella spiralis infection? |
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