Low shear stress induces endothelial reactive oxygen species via the AT1R/eNOS/NO pathway

Reactive oxygen species (ROS) contribute to many aspects of physiological and pathological cardiovascular processes. However, the underlying mechanism of ROS induction by low shear stress (LSS) remains unclear. Accumulating evidence has shown that the angiotensin II type 1 receptor (AT1R) is involve...

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Veröffentlicht in:	Journal of cellular physiology 2018-02, Vol.233 (2), p.1384-1395
Hauptverfasser:	Chao, Yuelin, Ye, Peng, Zhu, Linlin, Kong, Xiangquan, Qu, Xinliang, Zhang, Junxia, Luo, Jie, Yang, Hongfeng, Chen, Shaoliang
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiotensin Angiotensin II angiotensin II type 1 receptor Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Aorta Aorta, Thoracic - metabolism Aortic arch Apoptosis Arginine Cells, Cultured Chemiluminescence Curvature Cytometry Dephosphorylation Endothelial cells eNOS uncoupling Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Flow cytometry Fluorescence Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - enzymology Humans Immunofluorescence Immunohistochemistry low shear stress Mechanical stimuli Mechanotransduction, Cellular - drug effects Mice, Inbred C57BL NG-Nitroarginine methyl ester Nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Receptor, Angiotensin, Type 1 - drug effects Receptor, Angiotensin, Type 1 - metabolism Shear stress Single-nucleotide polymorphism Stress, Mechanical Time dependence Time Factors Umbilical vein Western blotting
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