Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor

Neuroendocrine tumors are rare, and little is known about the existence of cancer stem cells in this disease. Identification of the tumorigenic population will contribute to the development of effective therapies targeting neuroendocrine tumors. Surgically resected brain metastases from a primary ne...

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Veröffentlicht in:	Medical molecular morphology 2017-12, Vol.50 (4), p.211-219
Hauptverfasser:	Iwata, Ryoichi, Maruyama, Masato, Ito, Tomoki, Nakano, Yosuke, Kanemura, Yonehiro, Koike, Taro, Oe, Souichi, Yoshimura, Kunikazu, Nonaka, Masahiro, Nomura, Shosaku, Sugimoto, Tetsuo, Yamada, Hisao, Asai, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen - genetics AC133 Antigen - metabolism Aged Aldehyde dehydrogenase Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - metabolism Anatomy Animals Antineoplastic Agents, Alkylating - pharmacology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - secondary Brain Neoplasms - surgery Brain stem Brain tumors Cancer Cell self-renewal Cell Survival - drug effects Chromogranin A - genetics Chromogranin A - metabolism Cytotoxicity Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Humans Male Medicine Medicine & Public Health Metastases Metastasis Mice Molecular Medicine Neoplasm Transplantation Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nestin Nestin - genetics Nestin - metabolism Neuroendocrine system Neuroendocrine tumors Neuroendocrine Tumors - drug therapy Neuroendocrine Tumors - genetics Neuroendocrine Tumors - pathology Neuroendocrine Tumors - surgery Original Paper Pathology Primary Cell Culture SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Stem cells Synaptophysin Synaptophysin - genetics Synaptophysin - metabolism Temozolomide Tumor Cells, Cultured Tumors Xenografts
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