Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases

The prognosis for autoimmune thyroid diseases (AITDs), such as Hashimoto’s disease (HD) and Graves’ disease (GD), varies among patients. Interleukin (IL)-12 and IL-18 also induce Th1 differentiation, and SOCS1 (Suppressor of cytokine signaling 1) and TIM-3 (T cell immunoglobulin and mucin domain-3)...

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Veröffentlicht in:	Endocrine Journal 2017, Vol.64(7), pp.695-703
Hauptverfasser:	Inoue, Naoya, Watanabe, Mikio, Nakaguchi, Azusa, Ueda, Daishi, Kawaguti, Hayaka, Hidaka, Yoh, Iwatani, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AITD Alleles Amino Acid Substitution Cell Differentiation Female Gene Frequency Genetic Association Studies Genotypes Graves Disease - diagnosis Graves Disease - genetics Graves Disease - pathology Graves Disease - physiopathology Hashimoto Disease - genetics Hashimoto Disease - immunology Hashimoto Disease - pathology Hashimoto Disease - physiopathology Hepatitis A Virus Cellular Receptor 2 - genetics Hepatitis A Virus Cellular Receptor 2 - metabolism Humans IL-12 IL-18 Interleukin 1 Interleukin 12 Interleukin 18 Interleukin-12 Subunit p35 - genetics Interleukin-12 Subunit p35 - metabolism Japan Lymphocytes T Middle Aged Mucin Polymorphism Polymorphism, Single Nucleotide Prognosis Receptors, Interleukin-12 - genetics Receptors, Interleukin-12 - metabolism Remission Severity of Illness Index SOCS-1 protein SOCS1 Suppressor of Cytokine Signaling 1 Protein - genetics Suppressor of Cytokine Signaling 1 Protein - metabolism Th1 Cells - immunology Th1 Cells - pathology Thyroid diseases
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