FXYD5 (dysadherin) may mediate metastatic progression through regulation of the β-Na + -K + -ATPase subunit in the 4T1 mouse breast cancer model

FXYD5 is a Na -K -ATPase regulator, expressed in a variety of normal epithelia. In parallel, it has been found to be associated with several types of cancer and effect lethal outcome by promoting metastasis. However, the molecular mechanism underlying FXYD5 mediated invasion has not yet been identif...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2017-07, Vol.313 (1), p.C108-C117
Hauptverfasser:	Lubarski-Gotliv, Irina, Dey, Kuntal, Kuznetsov, Yuri, Kalchenco, Vecheslav, Asher, Carol, Garty, Haim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A2 - genetics Annexin A2 - metabolism Cadherins - genetics Cadherins - metabolism Cell Adhesion Cell Line, Tumor Cell Movement Disease Models, Animal Female Gene Expression Regulation, Neoplastic Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - secondary Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Membrane Proteins - antagonists & inhibitors Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred BALB C Neoplasms, Adipose Tissue - genetics Neoplasms, Adipose Tissue - metabolism Neoplasms, Adipose Tissue - pathology Protein Subunits - genetics Protein Subunits - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Signal Transduction Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism
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