Attenuation of deregulated miR-369-3p expression sensitizes non-small cell lung cancer cells to cisplatin via modulation of the nucleotide sugar transporter SLC35F5

Deregulation of the microRNAs (miRNAs), a cluster of important posttranscriptional regulators, has been frequently associated with lung cancer (LCa). However, the emerging mechanism for how miRNAs is linked causally in the development of LCa chemoresistance is poorly understood. Herein, we establish...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-07, Vol.488 (3), p.501-508
Hauptverfasser:	Hao, Guang-jun, Ding, Yan-hui, Wen, Hui, Li, Xiao-feng, Zhang, Wei, Su, Hu-yan, Liu, Dong-mei, Xie, Nian-lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Chemoresistance Cisplatin Cisplatin - pharmacology Gene Expression Profiling Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - metabolism miR-369-3p Monosaccharide Transport Proteins - genetics Monosaccharide Transport Proteins - metabolism Nonsmall cell lung cancer (NSCLC) SLC35F5 Tumor Cells, Cultured
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