Conditioned medium from relapsing-remitting multiple sclerosis patients reduces the expression and release of inflammatory cytokines induced by LPS-gingivalis in THP-1 and MO3.13 cell lines

•hPDLSCs-conditioned medium (CM) provides anti-inflammatory effects in THP-1 and MO3.13 cells.•hPDLSCs-CM is also effective when obtained by Relapsing-Remitting MS patients.•hPDLSCs-CM may provide a novel potential autologous stem cell-free therapeutic strategy. The present research was aimed at eva...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2017-08, Vol.96, p.261-272
Hauptverfasser:	Ballerini, Patrizia, Diomede, Francesca, Petragnani, Nicola, Cicchitti, Simona, Merciaro, Ilaria, Cavalcanti, Marcos F.X.B., Trubiani, Oriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Cell Differentiation Cell Line Cell Survival - drug effects Cells, Cultured Conditioned medium Culture Media, Conditioned Cytokines Cytokines - genetics Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Human periodontal ligament stem cells Humans Lipopolysaccharides - immunology LPS-Porphyromonas gingivalis MO3.13 Monocytes - immunology Monocytes - metabolism Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - physiopathology Oligodendrocytes Oligodendroglia - immunology Oligodendroglia - metabolism Periodontal Ligament - metabolism Periodontal Ligament - pathology Porphyromonas gingivalis - immunology Real-Time Polymerase Chain Reaction Stem Cells - metabolism Stem Cells - physiology THP-1 THP-1 Cells
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