Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer

BACKGROUND Colorectal cancer (CRC) develops through the alteration of several critical pathways. This study was aimed at evaluating the influence of critical pathways on survival outcomes for patients with CRC. METHODS Targeted next‐generation sequencing of 40 genes included in the 5 critical pathwa...

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Veröffentlicht in:	Cancer 2017-09, Vol.123 (18), p.3513-3523
Hauptverfasser:	Lee, Dae‐Won, Han, Sae‐Won, Cha, Yongjun, Bae, Jeong Mo, Kim, Hwang‐Phill, Lyu, Jaemyun, Han, Hyojun, Kim, Hyoki, Jang, Hoon, Bang, Duhee, Huh, Iksoo, Park, Taesung, Won, Jae‐Kyung, Jeong, Seung‐Yong, Park, Kyu Joo, Kang, Gyeong Hoon, Kim, Tae‐You
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adenomatous polyposis coli Adult Aged Cancer cancer genetics Catalysis Chemotherapy Chemotherapy, Adjuvant Class I Phosphatidylinositol 3-Kinases - genetics Cohort Studies Colectomy - methods Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Combined Modality Therapy Confidence Intervals Critical Pathways Female Gene Expression Regulation, Neoplastic Gene sequencing Genes Genes, ras Homology Humans K-Ras protein Kinases Male Medical prognosis Middle Aged Mutation Mutation rates Neuroblastoma Odds Ratio Oncology Oxaliplatin p53 Protein pathway mutation Patients Phosphatidylinositol 4,5-diphosphate Polyposis coli Predictive Value of Tests Prognosis Protein-serine/threonine kinase Proto-Oncogenes - genetics Raf protein Receptor, Epidermal Growth Factor - genetics Republic of Korea Retrospective Studies Sarcoma Surgery Survival Survival Analysis Treatment Outcome tumor location Tumors Wnt protein
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