Characterization and quantitation of PVP content in a silicone hydrogel contact lens produced by dual-phase polymerization processing
Polyvinylpyrrolidone (PVP) has been incorporated over the years into numerous hydrogel contact lenses as both a primary matrix component and an internal wetting agent to increase lens wettability. In this study, complementary analytical techniques were used to characterize the PVP wetting agent comp...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2018-04, Vol.106 (3), p.1064-1072 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
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| creator | Hoteling, Andrew J Nichols, William F Harmon, Patricia S Conlon, Shawn M Nuñez, Ivan M Hoff, Joseph W Cabarcos, Orlando M Steffen, Robert B Hook, Daniel J |
| description | Polyvinylpyrrolidone (PVP) has been incorporated over the years into numerous hydrogel contact lenses as both a primary matrix component and an internal wetting agent to increase lens wettability. In this study, complementary analytical techniques were used to characterize the PVP wetting agent component of senofilcon A and samfilcon A contact lenses, both in terms of chemical composition and amount present. Photo-differential scanning calorimetry (photo-DSC), gas chromatography with a flame ionization detector (GC-FID), and high-resolution/accurate mass (HR/AM) liquid chromatography-mass spectrometry (LC-MS) techniques confirmed dual phase reaction and curing of the samfilcon A silicone hydrogel material. Gel permeation chromatography (GPC) demonstrated that high molecular weight (HMW) polymer was present in isopropanol (IPA) extracts of both lenses. High-performance liquid chromatography (HPLC) effectively separated hydrophilic PVP from the hydrophobic silicone polymers present in the extracts. Collectively, atmospheric solids analysis probe mass spectrometry (ASAP MS), Fourier transform infrared (FTIR) spectroscopy,
H nuclear magnetic resonance (NMR) spectroscopy, GC-FID, and LC-MS analyses of the lens extracts indicated that the majority of NVP is consumed during the second reaction phase of samfilcon A lens polymerization and exists as HMW PVP, similar to the PVP present in senofilcon A. GC-FID analysis of pyrolyzed samfilcon A and senofilcon A indicates fourfold greater PVP in samfilcon A compared with senofilcon A. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1064-1072, 2018. |
| doi_str_mv | 10.1002/jbm.b.33904 |
| format | Article |
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H nuclear magnetic resonance (NMR) spectroscopy, GC-FID, and LC-MS analyses of the lens extracts indicated that the majority of NVP is consumed during the second reaction phase of samfilcon A lens polymerization and exists as HMW PVP, similar to the PVP present in senofilcon A. GC-FID analysis of pyrolyzed samfilcon A and senofilcon A indicates fourfold greater PVP in samfilcon A compared with senofilcon A. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1064-1072, 2018.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.33904</identifier><identifier>PMID: 28508428</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Biomedical materials ; Calorimetry ; Chromatography ; Contact lenses ; Differential scanning calorimetry ; Flame ionization ; Flame ionization detectors ; Fourier transforms ; Gas chromatography ; High performance liquid chromatography ; Hydrogels ; Hydrophobicity ; Infrared analysis ; Ionization ; Ionization counters ; Liquid chromatography ; Magnetic lenses ; Mass spectrometry ; Mass spectroscopy ; Materials research ; Materials science ; Molecular weight ; NMR ; Nuclear magnetic resonance ; Polymerization ; Polymers ; Polyvinylpyrrolidone ; Quantitation ; Scientific imaging ; Silicone resins ; Silicones ; Spectroscopy ; Wettability ; Wetting</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2018-04, Vol.106 (3), p.1064-1072</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-7470a8194714e3f0a90f01cf479d0a7177c46d088a69853d36143bc0744b7dc33</citedby><cites>FETCH-LOGICAL-c383t-7470a8194714e3f0a90f01cf479d0a7177c46d088a69853d36143bc0744b7dc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28508428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoteling, Andrew J</creatorcontrib><creatorcontrib>Nichols, William F</creatorcontrib><creatorcontrib>Harmon, Patricia S</creatorcontrib><creatorcontrib>Conlon, Shawn M</creatorcontrib><creatorcontrib>Nuñez, Ivan M</creatorcontrib><creatorcontrib>Hoff, Joseph W</creatorcontrib><creatorcontrib>Cabarcos, Orlando M</creatorcontrib><creatorcontrib>Steffen, Robert B</creatorcontrib><creatorcontrib>Hook, Daniel J</creatorcontrib><title>Characterization and quantitation of PVP content in a silicone hydrogel contact lens produced by dual-phase polymerization processing</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><description>Polyvinylpyrrolidone (PVP) has been incorporated over the years into numerous hydrogel contact lenses as both a primary matrix component and an internal wetting agent to increase lens wettability. In this study, complementary analytical techniques were used to characterize the PVP wetting agent component of senofilcon A and samfilcon A contact lenses, both in terms of chemical composition and amount present. Photo-differential scanning calorimetry (photo-DSC), gas chromatography with a flame ionization detector (GC-FID), and high-resolution/accurate mass (HR/AM) liquid chromatography-mass spectrometry (LC-MS) techniques confirmed dual phase reaction and curing of the samfilcon A silicone hydrogel material. Gel permeation chromatography (GPC) demonstrated that high molecular weight (HMW) polymer was present in isopropanol (IPA) extracts of both lenses. High-performance liquid chromatography (HPLC) effectively separated hydrophilic PVP from the hydrophobic silicone polymers present in the extracts. Collectively, atmospheric solids analysis probe mass spectrometry (ASAP MS), Fourier transform infrared (FTIR) spectroscopy,
H nuclear magnetic resonance (NMR) spectroscopy, GC-FID, and LC-MS analyses of the lens extracts indicated that the majority of NVP is consumed during the second reaction phase of samfilcon A lens polymerization and exists as HMW PVP, similar to the PVP present in senofilcon A. GC-FID analysis of pyrolyzed samfilcon A and senofilcon A indicates fourfold greater PVP in samfilcon A compared with senofilcon A. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1064-1072, 2018.</description><subject>Biomedical materials</subject><subject>Calorimetry</subject><subject>Chromatography</subject><subject>Contact lenses</subject><subject>Differential scanning calorimetry</subject><subject>Flame ionization</subject><subject>Flame ionization detectors</subject><subject>Fourier transforms</subject><subject>Gas chromatography</subject><subject>High performance liquid chromatography</subject><subject>Hydrogels</subject><subject>Hydrophobicity</subject><subject>Infrared analysis</subject><subject>Ionization</subject><subject>Ionization counters</subject><subject>Liquid chromatography</subject><subject>Magnetic lenses</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Molecular weight</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Polyvinylpyrrolidone</subject><subject>Quantitation</subject><subject>Scientific imaging</subject><subject>Silicone resins</subject><subject>Silicones</subject><subject>Spectroscopy</subject><subject>Wettability</subject><subject>Wetting</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpd0c1rHCEYBnApDc1He-o9CL0EwmxeR2fUY1jSphBIDkmv4qiTdZnRjc4cNvf-3zXZ7RZ6Ul5_PK_wIPSVwIIA1Ffrblx0C0olsA_ohDRNXTEpyMfDndNjdJrzuuAWGvoJHdeiAcFqcYJ-L1c6aTO55F_15GPAOlj8Musw-Wk3iD1--PWATQyTCxP2heDsB18GDq-2NsVnN7w_lxw8uJDxJkU7G2dxt8V21kO1Wens8CYO2_HfpqKMy9mH58_oqNdDdl_25xl6-n7zuLyt7u5__Fxe31WGCjpVnHHQgkjGCXO0By2hB2J6xqUFzQnnhrUWhNCtFA21tCWMdgY4Yx23htIzdLHLLatfZpcnNfps3DDo4OKcFRFSMmipYIV--4-u45xC-Z2qgdQMZEOaoi53yqSYc3K92iQ_6rRVBNRbO6q0ozr13k7R5_vMuRudPdi_ddA_l9-MEQ</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Hoteling, Andrew J</creator><creator>Nichols, William F</creator><creator>Harmon, Patricia S</creator><creator>Conlon, Shawn M</creator><creator>Nuñez, Ivan M</creator><creator>Hoff, Joseph W</creator><creator>Cabarcos, Orlando M</creator><creator>Steffen, Robert B</creator><creator>Hook, Daniel J</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Characterization and quantitation of PVP content in a silicone hydrogel contact lens produced by dual-phase polymerization processing</title><author>Hoteling, Andrew J ; Nichols, William F ; Harmon, Patricia S ; Conlon, Shawn M ; Nuñez, Ivan M ; Hoff, Joseph W ; Cabarcos, Orlando M ; Steffen, Robert B ; Hook, Daniel J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-7470a8194714e3f0a90f01cf479d0a7177c46d088a69853d36143bc0744b7dc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomedical materials</topic><topic>Calorimetry</topic><topic>Chromatography</topic><topic>Contact lenses</topic><topic>Differential scanning calorimetry</topic><topic>Flame ionization</topic><topic>Flame ionization detectors</topic><topic>Fourier transforms</topic><topic>Gas chromatography</topic><topic>High performance liquid chromatography</topic><topic>Hydrogels</topic><topic>Hydrophobicity</topic><topic>Infrared analysis</topic><topic>Ionization</topic><topic>Ionization counters</topic><topic>Liquid chromatography</topic><topic>Magnetic lenses</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Materials research</topic><topic>Materials science</topic><topic>Molecular weight</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Polymerization</topic><topic>Polymers</topic><topic>Polyvinylpyrrolidone</topic><topic>Quantitation</topic><topic>Scientific imaging</topic><topic>Silicone resins</topic><topic>Silicones</topic><topic>Spectroscopy</topic><topic>Wettability</topic><topic>Wetting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoteling, Andrew J</creatorcontrib><creatorcontrib>Nichols, William F</creatorcontrib><creatorcontrib>Harmon, Patricia S</creatorcontrib><creatorcontrib>Conlon, Shawn M</creatorcontrib><creatorcontrib>Nuñez, Ivan M</creatorcontrib><creatorcontrib>Hoff, Joseph W</creatorcontrib><creatorcontrib>Cabarcos, Orlando M</creatorcontrib><creatorcontrib>Steffen, Robert B</creatorcontrib><creatorcontrib>Hook, Daniel J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoteling, Andrew J</au><au>Nichols, William F</au><au>Harmon, Patricia S</au><au>Conlon, Shawn M</au><au>Nuñez, Ivan M</au><au>Hoff, Joseph W</au><au>Cabarcos, Orlando M</au><au>Steffen, Robert B</au><au>Hook, Daniel J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization and quantitation of PVP content in a silicone hydrogel contact lens produced by dual-phase polymerization processing</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J Biomed Mater Res B Appl Biomater</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>106</volume><issue>3</issue><spage>1064</spage><epage>1072</epage><pages>1064-1072</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>Polyvinylpyrrolidone (PVP) has been incorporated over the years into numerous hydrogel contact lenses as both a primary matrix component and an internal wetting agent to increase lens wettability. In this study, complementary analytical techniques were used to characterize the PVP wetting agent component of senofilcon A and samfilcon A contact lenses, both in terms of chemical composition and amount present. Photo-differential scanning calorimetry (photo-DSC), gas chromatography with a flame ionization detector (GC-FID), and high-resolution/accurate mass (HR/AM) liquid chromatography-mass spectrometry (LC-MS) techniques confirmed dual phase reaction and curing of the samfilcon A silicone hydrogel material. Gel permeation chromatography (GPC) demonstrated that high molecular weight (HMW) polymer was present in isopropanol (IPA) extracts of both lenses. High-performance liquid chromatography (HPLC) effectively separated hydrophilic PVP from the hydrophobic silicone polymers present in the extracts. Collectively, atmospheric solids analysis probe mass spectrometry (ASAP MS), Fourier transform infrared (FTIR) spectroscopy,
H nuclear magnetic resonance (NMR) spectroscopy, GC-FID, and LC-MS analyses of the lens extracts indicated that the majority of NVP is consumed during the second reaction phase of samfilcon A lens polymerization and exists as HMW PVP, similar to the PVP present in senofilcon A. GC-FID analysis of pyrolyzed samfilcon A and senofilcon A indicates fourfold greater PVP in samfilcon A compared with senofilcon A. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1064-1072, 2018.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28508428</pmid><doi>10.1002/jbm.b.33904</doi><tpages>9</tpages></addata></record> |
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| subjects | Biomedical materials Calorimetry Chromatography Contact lenses Differential scanning calorimetry Flame ionization Flame ionization detectors Fourier transforms Gas chromatography High performance liquid chromatography Hydrogels Hydrophobicity Infrared analysis Ionization Ionization counters Liquid chromatography Magnetic lenses Mass spectrometry Mass spectroscopy Materials research Materials science Molecular weight NMR Nuclear magnetic resonance Polymerization Polymers Polyvinylpyrrolidone Quantitation Scientific imaging Silicone resins Silicones Spectroscopy Wettability Wetting |
| title | Characterization and quantitation of PVP content in a silicone hydrogel contact lens produced by dual-phase polymerization processing |
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