Synthesis of Spiropentadiene Pyrazolones by Rh(III)-Catalyzed Formal sp3 C–H Activation/Annulation

Synthesis of Spiropentadiene Pyrazolones by Rh(III)-Catalyzed Formal sp3 C–H Activation/Annulation

A Rh-catalyzed enol-directed formal sp3 C–H activation/annulation of α-arylidene pyrazolones with alkynes has been developed. This reaction provides a convenient route to synthesize spiropentadiene pyrazolones in good to excellent yields at room temperature, exhibiting good functional group toleranc...

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Veröffentlicht in:Organic letters 2017-06, Vol.19 (11), p.2829-2832
Hauptverfasser: Zheng, Jiuan, Li, Panpan, Gu, Meng, Lin, Aijun, Yao, Hequan
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container_end_page 2832
container_issue 11
container_start_page 2829
container_title Organic letters
container_volume 19
creator Zheng, Jiuan
Li, Panpan
Gu, Meng
Lin, Aijun
Yao, Hequan
description A Rh-catalyzed enol-directed formal sp3 C–H activation/annulation of α-arylidene pyrazolones with alkynes has been developed. This reaction provides a convenient route to synthesize spiropentadiene pyrazolones in good to excellent yields at room temperature, exhibiting good functional group tolerance, gram scalability, and high regioselectivity. Of note, the α-arylidene pyrazolone was introduced as a novel C3 synthon in C–H activation/annulation.
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title Synthesis of Spiropentadiene Pyrazolones by Rh(III)-Catalyzed Formal sp3 C–H Activation/Annulation
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