Romidepsin induces caspase-dependent cell death in human neuroblastoma cells

[Display omitted] •Romidepsin is an FDA-approved small molecule drug and a selective HDAC1/2 inhibitor.•Romidepsin potently induces caspase-dependent cell death in human neuroblastoma cells.•MYCN-amplified neuroblastoma cells are more sensitive to Romidepsin-induced death.•The cytotoxic dose of Romi...

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Veröffentlicht in:	Neuroscience letters 2017-07, Vol.653, p.12-18
Hauptverfasser:	Hegarty, Shane V., Togher, Katie L., O’Leary, Eimear, Solger, Franziska, Sullivan, Aideen M., O’Keeffe, Gerard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Apoptosis - drug effects Caspase Inhibitors - administration & dosage Caspases - metabolism Cell death Cell Line, Tumor Cell Survival - drug effects Chemotherapeutic drug Depsipeptides - administration & dosage Epigenetic regulation Histone Deacetylase Inhibitors - administration & dosage Humans Neuroblastoma Romidepsin
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