Non-maturational covariates for dynamic systems pharmacology models in neonates, infants, and children: Filling the gaps beyond developmental pharmacology

Pharmacokinetics and -dynamics show important changes throughout childhood. Studies on the different maturational processes that influence developmental pharmacology have been used to create population PK/PD models that can yield individualized pediatric drug dosages. These models were subsequently...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of pharmaceutical sciences 2017-11, Vol.109, p.S27-S31
Hauptverfasser:	Allegaert, Karel, Simons, Sinno H.P., Tibboel, Dick, Krekels, Elke H., Knibbe, Catherijne A., van den Anker, John N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Child Developmental pharmacology Dose-Response Relationship, Drug Humans Infant Infant, Newborn Models, Biological Neonatology Non-maturational covariates Pediatrics Pharmaceutical Preparations - administration & dosage Pharmacogenetics - methods Pharmacokinetics Precision Medicine - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!