Evidence of Altered Trigeminal Nociception in an Animal Model of Fibromyalgia
Abstract Objective Fibromyalgia (FM) is a debilitating chronic condition that significantly affects quality of life. A strong association has been demonstrated between FM and chronic pain in the trigeminal region in clinical studies. This study was performed to evaluate the response to acute and chr...
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| Veröffentlicht in: | Pain medicine (Malden, Mass.) Mass.), 2018-02, Vol.19 (2), p.328-335 |
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| creator | Nazeri, Masoud Zarei, Mohammad-Reza Pourzare, Amin-Reza Ghahreh-Chahi, Hamid-Reza Abareghi, Fatemeh Shabani, Mohammad |
| description | Abstract
Objective
Fibromyalgia (FM) is a debilitating chronic condition that significantly affects quality of life. A strong association has been demonstrated between FM and chronic pain in the trigeminal region in clinical studies. This study was performed to evaluate the response to acute and chronic noxious stimuli applied to the facial region.
Methods
Adult male Wistar rats (250–270 g, N = 10 for each group) were used in the current study. A subchronic swim stress model was used as the animal model of FM. Anxiety-like behaviors and response to acute and chronic noxious stimuli were assayed using the elevated plus maze, eye wiping test, and orofacial formalin test, respectively. Balance and motor function were evaluated using rotarod and wire grip tests.
Results
An increased anxiety-like behavior was observed in swim stress rats in comparison with control and sham subjects. Response to acute and chronic noxious stimuli in the trigeminal region was increased in the stressed rats. Motor and balance function were not altered following stress.
Conclusions
Results of the current study demonstrated a hyperalgesic state in the trigeminal region in a possible animal model of FM. This study provides a reliable animal model for further research on the possible mechanisms of orofacial pain in FM. |
| doi_str_mv | 10.1093/pm/pnx114 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1899404135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A588343005</galeid><oup_id>10.1093/pm/pnx114</oup_id><sourcerecordid>A588343005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-cfa7ab9ed708e5d202eda620e5dae2debcc0098e249ddcd0c656456478ca5a663</originalsourceid><addsrcrecordid>eNp9kV9rFDEUxYMotrY--AVkQB_0Ydubv5N5XEqrQmtf6nPIJneWlJlkTGbEfnuz7KoopSSQS_I7h5t7CHlD4YxCx8-n8XyKPykVz8gxlUythOLt80PNeCuPyKtS7gGoEpq_JEdMS5BcwjG5ufwRPEaHTeqb9TBjRt_c5bDFMUQ7NF-TCw6nOaTYhNjY2KxjGOvDTfI47ERXYZPT-GCHbbCn5EVvh4KvD-cJ-XZ1eXfxeXV9--nLxfp65UQL88r1trWbDn0LGqVnwNBbxaDWFpnHjXMAnUYmOu-dB6ekEnW32llpleIn5MPed8rp-4JlNmMoDofBRkxLMVR3nQBBuazou__Q-7Tk-rViGGUt16qT7V9qawc0IfZpztbtTM1aas0FB9h5nT1C1eXrtFyK2Id6_4_g417gciolY2-mXKeXHwwFs4vOTKPZR1fZt4dGl82I_g_5O6sKvN8DaZme8PkFwrCexg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2127386957</pqid></control><display><type>article</type><title>Evidence of Altered Trigeminal Nociception in an Animal Model of Fibromyalgia</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Nazeri, Masoud ; Zarei, Mohammad-Reza ; Pourzare, Amin-Reza ; Ghahreh-Chahi, Hamid-Reza ; Abareghi, Fatemeh ; Shabani, Mohammad</creator><creatorcontrib>Nazeri, Masoud ; Zarei, Mohammad-Reza ; Pourzare, Amin-Reza ; Ghahreh-Chahi, Hamid-Reza ; Abareghi, Fatemeh ; Shabani, Mohammad</creatorcontrib><description>Abstract
Objective
Fibromyalgia (FM) is a debilitating chronic condition that significantly affects quality of life. A strong association has been demonstrated between FM and chronic pain in the trigeminal region in clinical studies. This study was performed to evaluate the response to acute and chronic noxious stimuli applied to the facial region.
Methods
Adult male Wistar rats (250–270 g, N = 10 for each group) were used in the current study. A subchronic swim stress model was used as the animal model of FM. Anxiety-like behaviors and response to acute and chronic noxious stimuli were assayed using the elevated plus maze, eye wiping test, and orofacial formalin test, respectively. Balance and motor function were evaluated using rotarod and wire grip tests.
Results
An increased anxiety-like behavior was observed in swim stress rats in comparison with control and sham subjects. Response to acute and chronic noxious stimuli in the trigeminal region was increased in the stressed rats. Motor and balance function were not altered following stress.
Conclusions
Results of the current study demonstrated a hyperalgesic state in the trigeminal region in a possible animal model of FM. This study provides a reliable animal model for further research on the possible mechanisms of orofacial pain in FM.</description><identifier>ISSN: 1526-2375</identifier><identifier>EISSN: 1526-4637</identifier><identifier>DOI: 10.1093/pm/pnx114</identifier><identifier>PMID: 28505350</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Analysis ; Animals ; Anxiety ; Chronic illnesses ; Chronic pain ; Clinical trials ; Disease Models, Animal ; Facial Pain - physiopathology ; Fibromyalgia ; Fibromyalgia - physiopathology ; Formaldehyde ; Hyperalgesia - physiopathology ; Male ; Medical research ; Milnacipran ; Neurology ; Nociception - physiology ; Pain perception ; Quality of life ; Rats ; Rats, Wistar ; Rodents ; Stress, Psychological</subject><ispartof>Pain medicine (Malden, Mass.), 2018-02, Vol.19 (2), p.328-335</ispartof><rights>2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2017</rights><rights>2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><rights>COPYRIGHT 2018 Oxford University Press</rights><rights>Copyright © 2017 American Academy of Pain Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-cfa7ab9ed708e5d202eda620e5dae2debcc0098e249ddcd0c656456478ca5a663</citedby><cites>FETCH-LOGICAL-c470t-cfa7ab9ed708e5d202eda620e5dae2debcc0098e249ddcd0c656456478ca5a663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28505350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nazeri, Masoud</creatorcontrib><creatorcontrib>Zarei, Mohammad-Reza</creatorcontrib><creatorcontrib>Pourzare, Amin-Reza</creatorcontrib><creatorcontrib>Ghahreh-Chahi, Hamid-Reza</creatorcontrib><creatorcontrib>Abareghi, Fatemeh</creatorcontrib><creatorcontrib>Shabani, Mohammad</creatorcontrib><title>Evidence of Altered Trigeminal Nociception in an Animal Model of Fibromyalgia</title><title>Pain medicine (Malden, Mass.)</title><addtitle>Pain Med</addtitle><description>Abstract
Objective
Fibromyalgia (FM) is a debilitating chronic condition that significantly affects quality of life. A strong association has been demonstrated between FM and chronic pain in the trigeminal region in clinical studies. This study was performed to evaluate the response to acute and chronic noxious stimuli applied to the facial region.
Methods
Adult male Wistar rats (250–270 g, N = 10 for each group) were used in the current study. A subchronic swim stress model was used as the animal model of FM. Anxiety-like behaviors and response to acute and chronic noxious stimuli were assayed using the elevated plus maze, eye wiping test, and orofacial formalin test, respectively. Balance and motor function were evaluated using rotarod and wire grip tests.
Results
An increased anxiety-like behavior was observed in swim stress rats in comparison with control and sham subjects. Response to acute and chronic noxious stimuli in the trigeminal region was increased in the stressed rats. Motor and balance function were not altered following stress.
Conclusions
Results of the current study demonstrated a hyperalgesic state in the trigeminal region in a possible animal model of FM. This study provides a reliable animal model for further research on the possible mechanisms of orofacial pain in FM.</description><subject>Analysis</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Chronic illnesses</subject><subject>Chronic pain</subject><subject>Clinical trials</subject><subject>Disease Models, Animal</subject><subject>Facial Pain - physiopathology</subject><subject>Fibromyalgia</subject><subject>Fibromyalgia - physiopathology</subject><subject>Formaldehyde</subject><subject>Hyperalgesia - physiopathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Milnacipran</subject><subject>Neurology</subject><subject>Nociception - physiology</subject><subject>Pain perception</subject><subject>Quality of life</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Stress, Psychological</subject><issn>1526-2375</issn><issn>1526-4637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV9rFDEUxYMotrY--AVkQB_0Ydubv5N5XEqrQmtf6nPIJneWlJlkTGbEfnuz7KoopSSQS_I7h5t7CHlD4YxCx8-n8XyKPykVz8gxlUythOLt80PNeCuPyKtS7gGoEpq_JEdMS5BcwjG5ufwRPEaHTeqb9TBjRt_c5bDFMUQ7NF-TCw6nOaTYhNjY2KxjGOvDTfI47ERXYZPT-GCHbbCn5EVvh4KvD-cJ-XZ1eXfxeXV9--nLxfp65UQL88r1trWbDn0LGqVnwNBbxaDWFpnHjXMAnUYmOu-dB6ekEnW32llpleIn5MPed8rp-4JlNmMoDofBRkxLMVR3nQBBuazou__Q-7Tk-rViGGUt16qT7V9qawc0IfZpztbtTM1aas0FB9h5nT1C1eXrtFyK2Id6_4_g417gciolY2-mXKeXHwwFs4vOTKPZR1fZt4dGl82I_g_5O6sKvN8DaZme8PkFwrCexg</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Nazeri, Masoud</creator><creator>Zarei, Mohammad-Reza</creator><creator>Pourzare, Amin-Reza</creator><creator>Ghahreh-Chahi, Hamid-Reza</creator><creator>Abareghi, Fatemeh</creator><creator>Shabani, Mohammad</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Evidence of Altered Trigeminal Nociception in an Animal Model of Fibromyalgia</title><author>Nazeri, Masoud ; Zarei, Mohammad-Reza ; Pourzare, Amin-Reza ; Ghahreh-Chahi, Hamid-Reza ; Abareghi, Fatemeh ; Shabani, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-cfa7ab9ed708e5d202eda620e5dae2debcc0098e249ddcd0c656456478ca5a663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Chronic illnesses</topic><topic>Chronic pain</topic><topic>Clinical trials</topic><topic>Disease Models, Animal</topic><topic>Facial Pain - physiopathology</topic><topic>Fibromyalgia</topic><topic>Fibromyalgia - physiopathology</topic><topic>Formaldehyde</topic><topic>Hyperalgesia - physiopathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Milnacipran</topic><topic>Neurology</topic><topic>Nociception - physiology</topic><topic>Pain perception</topic><topic>Quality of life</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Stress, Psychological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nazeri, Masoud</creatorcontrib><creatorcontrib>Zarei, Mohammad-Reza</creatorcontrib><creatorcontrib>Pourzare, Amin-Reza</creatorcontrib><creatorcontrib>Ghahreh-Chahi, Hamid-Reza</creatorcontrib><creatorcontrib>Abareghi, Fatemeh</creatorcontrib><creatorcontrib>Shabani, Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Pain medicine (Malden, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nazeri, Masoud</au><au>Zarei, Mohammad-Reza</au><au>Pourzare, Amin-Reza</au><au>Ghahreh-Chahi, Hamid-Reza</au><au>Abareghi, Fatemeh</au><au>Shabani, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of Altered Trigeminal Nociception in an Animal Model of Fibromyalgia</atitle><jtitle>Pain medicine (Malden, Mass.)</jtitle><addtitle>Pain Med</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>19</volume><issue>2</issue><spage>328</spage><epage>335</epage><pages>328-335</pages><issn>1526-2375</issn><eissn>1526-4637</eissn><abstract>Abstract
Objective
Fibromyalgia (FM) is a debilitating chronic condition that significantly affects quality of life. A strong association has been demonstrated between FM and chronic pain in the trigeminal region in clinical studies. This study was performed to evaluate the response to acute and chronic noxious stimuli applied to the facial region.
Methods
Adult male Wistar rats (250–270 g, N = 10 for each group) were used in the current study. A subchronic swim stress model was used as the animal model of FM. Anxiety-like behaviors and response to acute and chronic noxious stimuli were assayed using the elevated plus maze, eye wiping test, and orofacial formalin test, respectively. Balance and motor function were evaluated using rotarod and wire grip tests.
Results
An increased anxiety-like behavior was observed in swim stress rats in comparison with control and sham subjects. Response to acute and chronic noxious stimuli in the trigeminal region was increased in the stressed rats. Motor and balance function were not altered following stress.
Conclusions
Results of the current study demonstrated a hyperalgesic state in the trigeminal region in a possible animal model of FM. This study provides a reliable animal model for further research on the possible mechanisms of orofacial pain in FM.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>28505350</pmid><doi>10.1093/pm/pnx114</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pain medicine (Malden, Mass.), 2018-02, Vol.19 (2), p.328-335 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Analysis Animals Anxiety Chronic illnesses Chronic pain Clinical trials Disease Models, Animal Facial Pain - physiopathology Fibromyalgia Fibromyalgia - physiopathology Formaldehyde Hyperalgesia - physiopathology Male Medical research Milnacipran Neurology Nociception - physiology Pain perception Quality of life Rats Rats, Wistar Rodents Stress, Psychological |
| title | Evidence of Altered Trigeminal Nociception in an Animal Model of Fibromyalgia |
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