Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood–brain barrier maturation

•High brain levels of pyrethroids result in increased neurotoxicity in immature rats.•Low metabolic inactivation of parent pyrethroids results in elevated brain levels.•Reduced protein binding in immature rats plasma is not sufficient to impact brain uptake.•Brain uptake of DLM from infantile rat or...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2017-09, Vol.62, p.24-29
Hauptverfasser:	Amaraneni, Manoj, Pang, Jing, Mortuza, Tanzir B., Muralidhara, Srinivasa, Cummings, Brian S., White, Catherine A., Vorhees, Charles V., Zastre, Jason, Bruckner, James V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Age Age Factors Agrochemicals Albumins - pharmacology Animals Animals, Newborn Binding Blood plasma Blood Proteins - metabolism Blood-brain barrier Blood-Brain Barrier - embryology Blood-Brain Barrier - growth & development Blood-Brain Barrier - metabolism Brain Brain - drug effects Brain - embryology Brain - enzymology Brain - metabolism Brain uptake Carotid artery Child, Preschool Deltamethrin Deposition Developmental neurotoxicity Dose-Response Relationship, Drug Embryo, Mammalian Female Fetus Human serum albumin Humans Infant Infant, Newborn Insecticides Insecticides - metabolism Insecticides - pharmacokinetics Male Membrane permeability Neurotoxicity Nitriles - metabolism Nitriles - pharmacokinetics Permeability Permethrin Plasma protein binding Pregnancy Protein Binding - drug effects Pyrethrins - metabolism Pyrethrins - pharmacokinetics Pyrethroids Rats Rats, Sprague-Dawley Rodents Serum albumin Studies
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