Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice
OBJECTIVE Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in...
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| Veröffentlicht in: | Hormones (Athens, Greece) Greece), 2017-01, Vol.16 (1), p.62-74 |
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| creator | Hatzidis, Aikaterini Hicks, Jasmin A. Gelineau, Rachel R. Arruda, Nicole L. De Pina, Isabella Monteiro O’Connell, Karyn E. Seggio, Joseph A. |
| description | OBJECTIVE
Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice.
DESIGN
Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms.
RESULTS
Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet (
p
=0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement (
p
=0.999) or in controls (
p
=0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin (
p
=0.012) and leptin (
p |
| doi_str_mv | 10.14310/horm.2002.1720 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1899119187</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1899119187</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-c25a645d8125d2bbe86f35d8e04c904b3064fcd63aca3ed92000fc1601a527573</originalsourceid><addsrcrecordid>eNp1kE1P3DAQhq2qqCzQMzfkYw9kd-zESXyEVfnSSkhVOVuOM2ENcbzYzqr778l2obeeRqN53leah5BzBnNW5AwWax_cnAPwOas4fCEzLjhkdcXZVzJjDGSWg5TH5CTGF4BSyJp9I8e8FgA1lzOy-4XOb3VPfUc1XdvnddbpRFuL6ZI2Y6KDT3Tr-3FIOuwo_sFgbMRLGnCLIWKkvsFo047qoZ1iusFkTdbbV6Rx5zbJu0jtQJ3ukS5Fdb1alA_UWYNn5KjTfcTvH_OUPN38_L28y1aPt_fLq1Vm8kqmzHChy0K0NeOi5U2Dddnl04pQGAlFk0NZdKYtc210jq2cXEBnWAlMC16JKj8lPw69m-DfRoxJORsN9r0e0I9RsVpKxiSr9-jigJrgYwzYqU2wbvpbMVB_fau9b7X3rfa-p8TFR_nYOGz_8Z-CJwAOQJxOwzMG9eLHMEwP_7fzHSNHi3E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899119187</pqid></control><display><type>article</type><title>Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hatzidis, Aikaterini ; Hicks, Jasmin A. ; Gelineau, Rachel R. ; Arruda, Nicole L. ; De Pina, Isabella Monteiro ; O’Connell, Karyn E. ; Seggio, Joseph A.</creator><creatorcontrib>Hatzidis, Aikaterini ; Hicks, Jasmin A. ; Gelineau, Rachel R. ; Arruda, Nicole L. ; De Pina, Isabella Monteiro ; O’Connell, Karyn E. ; Seggio, Joseph A.</creatorcontrib><description>OBJECTIVE
Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice.
DESIGN
Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms.
RESULTS
Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet (
p
=0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement (
p
=0.999) or in controls (
p
=0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin (
p
=0.012) and leptin (
p
<0.001), glucose tolerance (
p
<0.001), and obesity (
p
<0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch (
p
=0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets (
p
=0.516).
CONCLUSIONS
These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.</description><identifier>ISSN: 1109-3099</identifier><identifier>EISSN: 2520-8721</identifier><identifier>DOI: 10.14310/horm.2002.1720</identifier><identifier>PMID: 28500829</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Blood Glucose ; Diabetes Mellitus - chemically induced ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; Endocrinology ; Glucose Tolerance Test ; Insulin - blood ; Leptin - blood ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Mice ; Mice, Inbred C57BL ; Motor Activity ; Obesity - chemically induced ; Research Paper ; Triglycerides - blood</subject><ispartof>Hormones (Athens, Greece), 2017-01, Vol.16 (1), p.62-74</ispartof><rights>Hellenic Endocrine Society 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-c25a645d8125d2bbe86f35d8e04c904b3064fcd63aca3ed92000fc1601a527573</citedby><cites>FETCH-LOGICAL-c379t-c25a645d8125d2bbe86f35d8e04c904b3064fcd63aca3ed92000fc1601a527573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.14310/horm.2002.1720$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.14310/horm.2002.1720$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28500829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hatzidis, Aikaterini</creatorcontrib><creatorcontrib>Hicks, Jasmin A.</creatorcontrib><creatorcontrib>Gelineau, Rachel R.</creatorcontrib><creatorcontrib>Arruda, Nicole L.</creatorcontrib><creatorcontrib>De Pina, Isabella Monteiro</creatorcontrib><creatorcontrib>O’Connell, Karyn E.</creatorcontrib><creatorcontrib>Seggio, Joseph A.</creatorcontrib><title>Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice</title><title>Hormones (Athens, Greece)</title><addtitle>Hormones</addtitle><addtitle>Hormones (Athens)</addtitle><description>OBJECTIVE
Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice.
DESIGN
Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms.
RESULTS
Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet (
p
=0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement (
p
=0.999) or in controls (
p
=0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin (
p
=0.012) and leptin (
p
<0.001), glucose tolerance (
p
<0.001), and obesity (
p
<0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch (
p
=0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets (
p
=0.516).
CONCLUSIONS
These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.</description><subject>Animals</subject><subject>Blood Glucose</subject><subject>Diabetes Mellitus - chemically induced</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - adverse effects</subject><subject>Endocrinology</subject><subject>Glucose Tolerance Test</subject><subject>Insulin - blood</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Motor Activity</subject><subject>Obesity - chemically induced</subject><subject>Research Paper</subject><subject>Triglycerides - blood</subject><issn>1109-3099</issn><issn>2520-8721</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhq2qqCzQMzfkYw9kd-zESXyEVfnSSkhVOVuOM2ENcbzYzqr778l2obeeRqN53leah5BzBnNW5AwWax_cnAPwOas4fCEzLjhkdcXZVzJjDGSWg5TH5CTGF4BSyJp9I8e8FgA1lzOy-4XOb3VPfUc1XdvnddbpRFuL6ZI2Y6KDT3Tr-3FIOuwo_sFgbMRLGnCLIWKkvsFo047qoZ1iusFkTdbbV6Rx5zbJu0jtQJ3ukS5Fdb1alA_UWYNn5KjTfcTvH_OUPN38_L28y1aPt_fLq1Vm8kqmzHChy0K0NeOi5U2Dddnl04pQGAlFk0NZdKYtc210jq2cXEBnWAlMC16JKj8lPw69m-DfRoxJORsN9r0e0I9RsVpKxiSr9-jigJrgYwzYqU2wbvpbMVB_fau9b7X3rfa-p8TFR_nYOGz_8Z-CJwAOQJxOwzMG9eLHMEwP_7fzHSNHi3E</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Hatzidis, Aikaterini</creator><creator>Hicks, Jasmin A.</creator><creator>Gelineau, Rachel R.</creator><creator>Arruda, Nicole L.</creator><creator>De Pina, Isabella Monteiro</creator><creator>O’Connell, Karyn E.</creator><creator>Seggio, Joseph A.</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice</title><author>Hatzidis, Aikaterini ; Hicks, Jasmin A. ; Gelineau, Rachel R. ; Arruda, Nicole L. ; De Pina, Isabella Monteiro ; O’Connell, Karyn E. ; Seggio, Joseph A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-c25a645d8125d2bbe86f35d8e04c904b3064fcd63aca3ed92000fc1601a527573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Blood Glucose</topic><topic>Diabetes Mellitus - chemically induced</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>Endocrinology</topic><topic>Glucose Tolerance Test</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Motor Activity</topic><topic>Obesity - chemically induced</topic><topic>Research Paper</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hatzidis, Aikaterini</creatorcontrib><creatorcontrib>Hicks, Jasmin A.</creatorcontrib><creatorcontrib>Gelineau, Rachel R.</creatorcontrib><creatorcontrib>Arruda, Nicole L.</creatorcontrib><creatorcontrib>De Pina, Isabella Monteiro</creatorcontrib><creatorcontrib>O’Connell, Karyn E.</creatorcontrib><creatorcontrib>Seggio, Joseph A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones (Athens, Greece)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hatzidis, Aikaterini</au><au>Hicks, Jasmin A.</au><au>Gelineau, Rachel R.</au><au>Arruda, Nicole L.</au><au>De Pina, Isabella Monteiro</au><au>O’Connell, Karyn E.</au><au>Seggio, Joseph A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice</atitle><jtitle>Hormones (Athens, Greece)</jtitle><stitle>Hormones</stitle><addtitle>Hormones (Athens)</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>62</spage><epage>74</epage><pages>62-74</pages><issn>1109-3099</issn><eissn>2520-8721</eissn><abstract>OBJECTIVE
Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice.
DESIGN
Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms.
RESULTS
Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet (
p
=0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement (
p
=0.999) or in controls (
p
=0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin (
p
=0.012) and leptin (
p
<0.001), glucose tolerance (
p
<0.001), and obesity (
p
<0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch (
p
=0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets (
p
=0.516).
CONCLUSIONS
These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28500829</pmid><doi>10.14310/horm.2002.1720</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1109-3099 |
| ispartof | Hormones (Athens, Greece), 2017-01, Vol.16 (1), p.62-74 |
| issn | 1109-3099 2520-8721 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1899119187 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Animals Blood Glucose Diabetes Mellitus - chemically induced Dietary Fats - administration & dosage Dietary Fats - adverse effects Endocrinology Glucose Tolerance Test Insulin - blood Leptin - blood Male Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Motor Activity Obesity - chemically induced Research Paper Triglycerides - blood |
| title | Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice |
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