Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice

OBJECTIVE Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in...

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Veröffentlicht in:Hormones (Athens, Greece) Greece), 2017-01, Vol.16 (1), p.62-74
Hauptverfasser: Hatzidis, Aikaterini, Hicks, Jasmin A., Gelineau, Rachel R., Arruda, Nicole L., De Pina, Isabella Monteiro, O’Connell, Karyn E., Seggio, Joseph A.
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container_issue 1
container_start_page 62
container_title Hormones (Athens, Greece)
container_volume 16
creator Hatzidis, Aikaterini
Hicks, Jasmin A.
Gelineau, Rachel R.
Arruda, Nicole L.
De Pina, Isabella Monteiro
O’Connell, Karyn E.
Seggio, Joseph A.
description OBJECTIVE Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice. DESIGN Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms. RESULTS Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet ( p =0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement ( p =0.999) or in controls ( p =0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin ( p =0.012) and leptin ( p
doi_str_mv 10.14310/horm.2002.1720
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This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice. DESIGN Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms. RESULTS Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet ( p =0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement ( p =0.999) or in controls ( p =0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin ( p =0.012) and leptin ( p &lt;0.001), glucose tolerance ( p &lt;0.001), and obesity ( p &lt;0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch ( p =0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets ( p =0.516). CONCLUSIONS These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.</description><identifier>ISSN: 1109-3099</identifier><identifier>EISSN: 2520-8721</identifier><identifier>DOI: 10.14310/horm.2002.1720</identifier><identifier>PMID: 28500829</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Blood Glucose ; Diabetes Mellitus - chemically induced ; Dietary Fats - administration &amp; dosage ; Dietary Fats - adverse effects ; Endocrinology ; Glucose Tolerance Test ; Insulin - blood ; Leptin - blood ; Male ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Mice ; Mice, Inbred C57BL ; Motor Activity ; Obesity - chemically induced ; Research Paper ; Triglycerides - blood</subject><ispartof>Hormones (Athens, Greece), 2017-01, Vol.16 (1), p.62-74</ispartof><rights>Hellenic Endocrine Society 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-c25a645d8125d2bbe86f35d8e04c904b3064fcd63aca3ed92000fc1601a527573</citedby><cites>FETCH-LOGICAL-c379t-c25a645d8125d2bbe86f35d8e04c904b3064fcd63aca3ed92000fc1601a527573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.14310/horm.2002.1720$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.14310/horm.2002.1720$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28500829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hatzidis, Aikaterini</creatorcontrib><creatorcontrib>Hicks, Jasmin A.</creatorcontrib><creatorcontrib>Gelineau, Rachel R.</creatorcontrib><creatorcontrib>Arruda, Nicole L.</creatorcontrib><creatorcontrib>De Pina, Isabella Monteiro</creatorcontrib><creatorcontrib>O’Connell, Karyn E.</creatorcontrib><creatorcontrib>Seggio, Joseph A.</creatorcontrib><title>Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice</title><title>Hormones (Athens, Greece)</title><addtitle>Hormones</addtitle><addtitle>Hormones (Athens)</addtitle><description>OBJECTIVE Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice. DESIGN Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms. RESULTS Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet ( p =0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement ( p =0.999) or in controls ( p =0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin ( p =0.012) and leptin ( p &lt;0.001), glucose tolerance ( p &lt;0.001), and obesity ( p &lt;0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch ( p =0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets ( p =0.516). 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Hicks, Jasmin A. ; Gelineau, Rachel R. ; Arruda, Nicole L. ; De Pina, Isabella Monteiro ; O’Connell, Karyn E. ; Seggio, Joseph A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-c25a645d8125d2bbe86f35d8e04c904b3064fcd63aca3ed92000fc1601a527573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Blood Glucose</topic><topic>Diabetes Mellitus - chemically induced</topic><topic>Dietary Fats - administration &amp; dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>Endocrinology</topic><topic>Glucose Tolerance Test</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Motor Activity</topic><topic>Obesity - chemically induced</topic><topic>Research Paper</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hatzidis, Aikaterini</creatorcontrib><creatorcontrib>Hicks, Jasmin A.</creatorcontrib><creatorcontrib>Gelineau, Rachel R.</creatorcontrib><creatorcontrib>Arruda, Nicole L.</creatorcontrib><creatorcontrib>De Pina, Isabella Monteiro</creatorcontrib><creatorcontrib>O’Connell, Karyn E.</creatorcontrib><creatorcontrib>Seggio, Joseph A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones (Athens, Greece)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hatzidis, Aikaterini</au><au>Hicks, Jasmin A.</au><au>Gelineau, Rachel R.</au><au>Arruda, Nicole L.</au><au>De Pina, Isabella Monteiro</au><au>O’Connell, Karyn E.</au><au>Seggio, Joseph A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice</atitle><jtitle>Hormones (Athens, Greece)</jtitle><stitle>Hormones</stitle><addtitle>Hormones (Athens)</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>62</spage><epage>74</epage><pages>62-74</pages><issn>1109-3099</issn><eissn>2520-8721</eissn><abstract>OBJECTIVE Both the consumption of high-fat diets and exercise are known to produce alterations in metabolism and behavior. This study focuses on the effects of a change to a low-fat diet from a high-fat diet and voluntary exercise on obesity, type-2 diabetic-like symptoms, and locomotor behavior in male C57BL/6J mice. DESIGN Mice were initially given either a high-fat diet or regular chow, along with a cage with a running-wheel to mimic exercise, or one without, to determine to what extend exercise affects these symptoms. Then half of the mice given a high-fat diet were switched to regular chow to ascertain if the switch in diet would improve type-2 diabetic-like and obesity symptoms. RESULTS Wheel-running alone produced an improvement in insulin in mice continuously fed a high-fat diet ( p =0.006), but running-wheels did not produce any further improvements in mice with regular chow replacement ( p =0.999) or in controls ( p =0.996). Replacement of a high-fat diet with regular chow led to physiological improvements in insulin ( p =0.012) and leptin ( p &lt;0.001), glucose tolerance ( p &lt;0.001), and obesity ( p &lt;0.001), more so than exercise alone. Mice consuming a high-fat diet without a wheel exhibited reduced home-cage activity compared to controls after the diet switch ( p =0.030), while no reduction was found in running-wheel activity between high-fat diet and regular chow consuming mice after switching diets ( p =0.516). CONCLUSIONS These results suggest that exercise is only partially beneficial to improving health outcomes in mice consuming a high-fat diet, whereas incorporating a better diet, even without exercise, improves quality of health and can suppress T2DM symptoms and related conditions more so than exercise alone.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28500829</pmid><doi>10.14310/horm.2002.1720</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; Alma/SFX Local Collection
subjects Animals
Blood Glucose
Diabetes Mellitus - chemically induced
Dietary Fats - administration & dosage
Dietary Fats - adverse effects
Endocrinology
Glucose Tolerance Test
Insulin - blood
Leptin - blood
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Mice
Mice, Inbred C57BL
Motor Activity
Obesity - chemically induced
Research Paper
Triglycerides - blood
title Removal of a high-fat diet, but not voluntary exercise, reverses obesity and diabetic-like symptoms in male C57BL/6J mice
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