MAIT cells and MR1-antigen recognition

Highlights • MR1 presents vitamin B precursors and metabolites to MAIT cells. • The MR1-restricted T cell repertoire is diverse. • MAIT TCR heterogeneity can impact on MR1-antigen responsiveness. • MR1 presents drugs and drug-like molecules.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in immunology 2017-06, Vol.46, p.66-74
Hauptverfasser:	Keller, Andrew N, Corbett, Alexandra J, Wubben, Jacinta M, McCluskey, James, Rossjohn, Jamie
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigen Presentation - immunology Bacterial Infections Disease Susceptibility - immunology Disease Susceptibility - metabolism Histocompatibility Antigens Class I - chemistry Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Humans Immunity, Innate Minor Histocompatibility Antigens - chemistry Minor Histocompatibility Antigens - immunology Minor Histocompatibility Antigens - metabolism Mucosal-Associated Invariant T Cells - immunology Mucosal-Associated Invariant T Cells - metabolism Protein Binding Quantitative Structure-Activity Relationship Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Vitamin B Complex - immunology Vitamin B Complex - metabolism
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