Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO)
Treatment against bacterial infection is crucial for wound healing. Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with w...
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| Veröffentlicht in: | International journal of biological macromolecules 2017-10, Vol.103, p.234-241 |
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| creator | Gutha, Yuvaraja Pathak, Janak L. Zhang, Weijiang Zhang, Yaping Jiao, Xu |
| description | Treatment against bacterial infection is crucial for wound healing. Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with wound healing properties. CS/PVA/ZnO beads were synthesized, and characterized by using XRD, FTIR, SEM, and TEM analysis. Pure chitosan exhibits two peaks at 2θ=10 and 20 and the CS/PVA polymer matrix exhibit the peaks at 2θ=19.7° and another of low intensity at 2θ=11.5°. Pure ZnO shows the characteristic peaks at (100), (002), (101), (102), (110), (103), (200), and (112) that were in good agreement with wurtzite ore having hexagonal lattice structure. The antibacterial activity of CS/PVA/ZnO against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Antibacterial activity of CS/PVA/ZnO was higher than that of chitosan (CS) and poly(vinyl alcohol (PVA). Hemocompatibility and biocompatibility of CS/PVA/ZnO were tested in in vitro. Wound healing properties of CS/PVA/ZnO were tested in mice skin wound. CS/PVA/ZnO showed strong antimicrobial, wound healing effect, hemocompatibility and biocompatibility. Hence the results strongly support the possibility of using this novel CS/PVA/ZnO material for the anti bacterial and wound healing application. |
| doi_str_mv | 10.1016/j.ijbiomac.2017.05.020 |
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Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with wound healing properties. CS/PVA/ZnO beads were synthesized, and characterized by using XRD, FTIR, SEM, and TEM analysis. Pure chitosan exhibits two peaks at 2θ=10 and 20 and the CS/PVA polymer matrix exhibit the peaks at 2θ=19.7° and another of low intensity at 2θ=11.5°. Pure ZnO shows the characteristic peaks at (100), (002), (101), (102), (110), (103), (200), and (112) that were in good agreement with wurtzite ore having hexagonal lattice structure. The antibacterial activity of CS/PVA/ZnO against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Antibacterial activity of CS/PVA/ZnO was higher than that of chitosan (CS) and poly(vinyl alcohol (PVA). Hemocompatibility and biocompatibility of CS/PVA/ZnO were tested in in vitro. Wound healing properties of CS/PVA/ZnO were tested in mice skin wound. CS/PVA/ZnO showed strong antimicrobial, wound healing effect, hemocompatibility and biocompatibility. Hence the results strongly support the possibility of using this novel CS/PVA/ZnO material for the anti bacterial and wound healing application.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2017.05.020</identifier><identifier>PMID: 28499948</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial agent ; Biocompatibility ; Cell Line, Tumor ; Chitosan - chemistry ; CS/PVA/ZnO ; Escherichia coli - drug effects ; Humans ; Microspheres ; Polyvinyl Alcohol - chemistry ; Staphylococcus aureus - drug effects ; Wound healing ; Wound Healing - drug effects ; Zinc Oxide - chemistry</subject><ispartof>International journal of biological macromolecules, 2017-10, Vol.103, p.234-241</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-b4fb507e9638b0a0bd1a6a8fda57b6f7009c873bd465fb2eb5c381efda1ad6213</citedby><cites>FETCH-LOGICAL-c434t-b4fb507e9638b0a0bd1a6a8fda57b6f7009c873bd465fb2eb5c381efda1ad6213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2017.05.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28499948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gutha, Yuvaraja</creatorcontrib><creatorcontrib>Pathak, Janak L.</creatorcontrib><creatorcontrib>Zhang, Weijiang</creatorcontrib><creatorcontrib>Zhang, Yaping</creatorcontrib><creatorcontrib>Jiao, Xu</creatorcontrib><title>Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO)</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Treatment against bacterial infection is crucial for wound healing. Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with wound healing properties. CS/PVA/ZnO beads were synthesized, and characterized by using XRD, FTIR, SEM, and TEM analysis. Pure chitosan exhibits two peaks at 2θ=10 and 20 and the CS/PVA polymer matrix exhibit the peaks at 2θ=19.7° and another of low intensity at 2θ=11.5°. Pure ZnO shows the characteristic peaks at (100), (002), (101), (102), (110), (103), (200), and (112) that were in good agreement with wurtzite ore having hexagonal lattice structure. The antibacterial activity of CS/PVA/ZnO against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Antibacterial activity of CS/PVA/ZnO was higher than that of chitosan (CS) and poly(vinyl alcohol (PVA). Hemocompatibility and biocompatibility of CS/PVA/ZnO were tested in in vitro. Wound healing properties of CS/PVA/ZnO were tested in mice skin wound. CS/PVA/ZnO showed strong antimicrobial, wound healing effect, hemocompatibility and biocompatibility. Hence the results strongly support the possibility of using this novel CS/PVA/ZnO material for the anti bacterial and wound healing application.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agent</subject><subject>Biocompatibility</subject><subject>Cell Line, Tumor</subject><subject>Chitosan - chemistry</subject><subject>CS/PVA/ZnO</subject><subject>Escherichia coli - drug effects</subject><subject>Humans</subject><subject>Microspheres</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Wound healing</subject><subject>Wound Healing - drug effects</subject><subject>Zinc Oxide - chemistry</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlu2zAQhomiReOmfYVAR-cgaUYrdathpAsQIAW6HHohuIxqGjLpknJa5-lDw0mvvcwAM_8_y8fYFUKBgF25LexWWb-TuqgA-wLaAip4wRbI-yEHgPolWwA2mHOs4YK9iXGbql2L_DW7qHgzDEPDF2yzcrNVUs8UrJwy6Uz2xx9S3JCcrPuV7YPfU5gtxcyPmd7Y2Ufpyr2fjst7647JM2m_8dN1-WCdzvxfayhTJE3Mluuv5Zcfq_Knu7t-y16Ncor07ilfsu8fbr6tP-W3dx8_r1e3uW7qZs5VM6oWehq6miuQoAzKTvLRyLZX3dgDDJr3tTJN146qItXqmiOlPkrTVVhfsuV5bjr894HiLHY2apom6cgfokA-DIh91Zyk3Vmqg48x0Cj2we5kOAoEcaIstuKZsjhRFtCKRDkZr552HNSOzD_bM9YkeH8WUPr03lIQUVtymowNpGdhvP3fjkfJBJI_</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Gutha, Yuvaraja</creator><creator>Pathak, Janak L.</creator><creator>Zhang, Weijiang</creator><creator>Zhang, Yaping</creator><creator>Jiao, Xu</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO)</title><author>Gutha, Yuvaraja ; Pathak, Janak L. ; Zhang, Weijiang ; Zhang, Yaping ; Jiao, Xu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-b4fb507e9638b0a0bd1a6a8fda57b6f7009c873bd465fb2eb5c381efda1ad6213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agent</topic><topic>Biocompatibility</topic><topic>Cell Line, Tumor</topic><topic>Chitosan - chemistry</topic><topic>CS/PVA/ZnO</topic><topic>Escherichia coli - drug effects</topic><topic>Humans</topic><topic>Microspheres</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Wound healing</topic><topic>Wound Healing - drug effects</topic><topic>Zinc Oxide - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gutha, Yuvaraja</creatorcontrib><creatorcontrib>Pathak, Janak L.</creatorcontrib><creatorcontrib>Zhang, Weijiang</creatorcontrib><creatorcontrib>Zhang, Yaping</creatorcontrib><creatorcontrib>Jiao, Xu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gutha, Yuvaraja</au><au>Pathak, Janak L.</au><au>Zhang, Weijiang</au><au>Zhang, Yaping</au><au>Jiao, Xu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO)</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2017-10</date><risdate>2017</risdate><volume>103</volume><spage>234</spage><epage>241</epage><pages>234-241</pages><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Treatment against bacterial infection is crucial for wound healing. Development of cost-effective antibacterial agent with wound healing properties is still in high demand. In this study we aimed to design chitosan/poly(vinyl alcohol)/zinc oxide (CS/PVA/ZnO) beads as novel antibacterial agent with wound healing properties. CS/PVA/ZnO beads were synthesized, and characterized by using XRD, FTIR, SEM, and TEM analysis. Pure chitosan exhibits two peaks at 2θ=10 and 20 and the CS/PVA polymer matrix exhibit the peaks at 2θ=19.7° and another of low intensity at 2θ=11.5°. Pure ZnO shows the characteristic peaks at (100), (002), (101), (102), (110), (103), (200), and (112) that were in good agreement with wurtzite ore having hexagonal lattice structure. The antibacterial activity of CS/PVA/ZnO against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Antibacterial activity of CS/PVA/ZnO was higher than that of chitosan (CS) and poly(vinyl alcohol (PVA). Hemocompatibility and biocompatibility of CS/PVA/ZnO were tested in in vitro. Wound healing properties of CS/PVA/ZnO were tested in mice skin wound. CS/PVA/ZnO showed strong antimicrobial, wound healing effect, hemocompatibility and biocompatibility. Hence the results strongly support the possibility of using this novel CS/PVA/ZnO material for the anti bacterial and wound healing application.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28499948</pmid><doi>10.1016/j.ijbiomac.2017.05.020</doi><tpages>8</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agent Biocompatibility Cell Line, Tumor Chitosan - chemistry CS/PVA/ZnO Escherichia coli - drug effects Humans Microspheres Polyvinyl Alcohol - chemistry Staphylococcus aureus - drug effects Wound healing Wound Healing - drug effects Zinc Oxide - chemistry |
| title | Antibacterial and wound healing properties of chitosan/poly(vinyl alcohol)/zinc oxide beads (CS/PVA/ZnO) |
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