Design, Synthesis, and Structure–Activity Relationship Analysis of Thiazolo[3,2‐a]pyrimidine Derivatives with Anti‐inflammatory Activity in Acute Lung Injury

Acute lung injury (ALI) has a high lethality rate, and interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) contribute most to tissue deterioration in cases of ALI. In this study, we designed and synthesized a new series of thiazolo[3,2‐a]pyrimidine derivatives based on a previously identified l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ChemMedChem 2017-07, Vol.12 (13), p.1022-1032
Hauptverfasser:	Chen, Lingfeng, Jin, Yiyi, Fu, Weitao, Xiao, Siyang, Feng, Chen, Fang, Bo, Gu, Yugui, Li, Chenglong, Zhao, Yunjie, Liu, Zhiguo, Liang, Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury Acute Lung Injury - drug therapy Animals anti-inflammatory Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Attenuation cytokines Derivatives Drug development Drugs Inflammation Inhibitors Interleukin 6 Interleukin-6 - antagonists & inhibitors Interleukin-6 - genetics Interleukin-6 - metabolism interleukins Lethality Lipopolysaccharides Lipopolysaccharides - pharmacology Lungs Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Mice, Inbred C57BL Mice, Inbred ICR Peritoneum Pneumonia - drug therapy Pneumonia - metabolism Pyrimidines - administration & dosage Pyrimidines - chemical synthesis Pyrimidines - therapeutic use Quantitative Structure-Activity Relationship RNA, Messenger - metabolism Rodents Sepsis - drug therapy Sepsis - metabolism Synthesis Thiazoles - administration & dosage Thiazoles - chemical synthesis Thiazoles - therapeutic use thiazolo[3,2-a]pyrimidines Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Ventilators
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!