Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease

Abstract Introduction The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. Methods In 139 presymptomatic mutation carriers from the Dominantly Inherited...

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Veröffentlicht in:	Alzheimer's & dementia 2017-11, Vol.13 (11), p.1197-1206
Hauptverfasser:	Brown, Belinda M, Sohrabi, Hamid R, Taddei, Kevin, Gardener, Samantha L, Rainey-Smith, Stephanie R, Peiffer, Jeremiah J, Xiong, Chengjie, Fagan, Anne M, Benzinger, Tammie, Buckles, Virginia, Erickson, Kirk I, Clarnette, Roger, Shah, Tejal, Masters, Colin L, Weiner, Michael, Cairns, Nigel, Rossor, Martin, Graff-Radford, Neill R, Salloway, Stephen, Vöglein, Jonathan, Laske, Christoph, Noble, James, Schofield, Peter R, Bateman, Randall J, Morris, John C, Martins, Ralph N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Amyloid - metabolism Amyloid beta-Peptides - cerebrospinal fluid Amyloid beta-Protein Precursor - genetics Amyloid β Aniline Compounds Apolipoproteins E - genetics Brain - diagnostic imaging Brain - metabolism Cohort Studies Cross-Sectional Studies Dementia Exercise - physiology Female Genetics Genotype Humans Linear Models Magnetic Resonance Imaging Male Middle Aged Mutation - genetics Neurology Peptide Fragments - cerebrospinal fluid Physical activity Positron-Emission Tomography Presenilin-1 - genetics Presenilin-2 - genetics Surveys and Questionnaires Tau tau Proteins - cerebrospinal fluid Thiazoles
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