Veridical stimulus localization is linked to human area V5/MT+ activity
How the brain represents visual space is an unsolved mystery. Spatial localization becomes particularly challenging when visual information processing is briefly disrupted, as in the case of saccadic eye movements, blinks, or visual masks. As we have recently reported, a compression of visual space,...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2017-08, Vol.156, p.377-387 |
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| creator | Bonkhoff, Anna K. Zimmermann, Eckart Fink, Gereon R. |
| description | How the brain represents visual space is an unsolved mystery. Spatial localization becomes particularly challenging when visual information processing is briefly disrupted, as in the case of saccadic eye movements, blinks, or visual masks. As we have recently reported, a compression of visual space, illustrated by displacements of shortly flashed stimuli, can be observed in the temporal vicinity of masking stimuli during ocular fixation (Zimmermann et al., 2013). We here aimed at investigating the neural mechanisms underlying these displacements using functional magnetic resonance imaging. On the behavioral level, we detected significant stimulus displacement when visual masks were simultaneously presented. At the neural level, we observed decreased human motion complex V5/MT+ activation associated with these displacements: When comparing trials with a perceived stimulus shift in space to trials of veridical perception of stimulus localization, human V5/MT+ was significantly less activated although no differences in perceived motion can account for this. Data suggest an important role of human V5/MT+ in the process of spatial localization of briefly presented objects and thus extend current concepts of the functions of human V5/MT+.
•Human V5/MT+ is involved in the veridical localization of shortly presented objects.•Spatial mislocalization of shortly presented objects can be linked to deactivation of human V5/MT+.•Masking stimuli may exert a suppressive influence on human V5/MT+. |
| doi_str_mv | 10.1016/j.neuroimage.2017.05.010 |
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•Human V5/MT+ is involved in the veridical localization of shortly presented objects.•Spatial mislocalization of shortly presented objects can be linked to deactivation of human V5/MT+.•Masking stimuli may exert a suppressive influence on human V5/MT+.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2017.05.010</identifier><identifier>PMID: 28495637</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Brain ; Brain mapping ; Compression ; Eye ; Eye movements ; Female ; fMRI ; Functional magnetic resonance imaging ; Human V5/MT+ deactivation ; Humans ; Information processing ; Localization ; Magnetic Resonance Imaging ; Male ; Masks ; Medical imaging ; Middle Aged ; Motion detection ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Photic Stimulation ; Saccadic eye movements ; Space Perception - physiology ; Spatial shift ; Stimulus localization ; Studies ; Visual Cortex - physiology ; Visual masking ; Visual observation ; Visual perception ; Visual Perception - physiology ; Visual stimuli ; Young Adult</subject><ispartof>NeuroImage (Orlando, Fla.), 2017-08, Vol.156, p.377-387</ispartof><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 1, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-e90d5ebac13dd3f8966fdef2a95a94e74fb56620a7935b5d9690384a717301643</citedby><cites>FETCH-LOGICAL-c402t-e90d5ebac13dd3f8966fdef2a95a94e74fb56620a7935b5d9690384a717301643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1927845692?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28495637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonkhoff, Anna K.</creatorcontrib><creatorcontrib>Zimmermann, Eckart</creatorcontrib><creatorcontrib>Fink, Gereon R.</creatorcontrib><title>Veridical stimulus localization is linked to human area V5/MT+ activity</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>How the brain represents visual space is an unsolved mystery. Spatial localization becomes particularly challenging when visual information processing is briefly disrupted, as in the case of saccadic eye movements, blinks, or visual masks. As we have recently reported, a compression of visual space, illustrated by displacements of shortly flashed stimuli, can be observed in the temporal vicinity of masking stimuli during ocular fixation (Zimmermann et al., 2013). We here aimed at investigating the neural mechanisms underlying these displacements using functional magnetic resonance imaging. On the behavioral level, we detected significant stimulus displacement when visual masks were simultaneously presented. At the neural level, we observed decreased human motion complex V5/MT+ activation associated with these displacements: When comparing trials with a perceived stimulus shift in space to trials of veridical perception of stimulus localization, human V5/MT+ was significantly less activated although no differences in perceived motion can account for this. Data suggest an important role of human V5/MT+ in the process of spatial localization of briefly presented objects and thus extend current concepts of the functions of human V5/MT+.
•Human V5/MT+ is involved in the veridical localization of shortly presented objects.•Spatial mislocalization of shortly presented objects can be linked to deactivation of human V5/MT+.•Masking stimuli may exert a suppressive influence on human V5/MT+.</description><subject>Adult</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Compression</subject><subject>Eye</subject><subject>Eye movements</subject><subject>Female</subject><subject>fMRI</subject><subject>Functional magnetic resonance imaging</subject><subject>Human V5/MT+ deactivation</subject><subject>Humans</subject><subject>Information processing</subject><subject>Localization</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Masks</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Motion detection</subject><subject>Neuroimaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Photic Stimulation</subject><subject>Saccadic eye movements</subject><subject>Space Perception - physiology</subject><subject>Spatial shift</subject><subject>Stimulus localization</subject><subject>Studies</subject><subject>Visual Cortex - physiology</subject><subject>Visual masking</subject><subject>Visual observation</subject><subject>Visual perception</subject><subject>Visual Perception - physiology</subject><subject>Visual stimuli</subject><subject>Young Adult</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkEtr3DAQgEVJ6G7T_oUi6CVQ7JUsyfYck5AmhYRe0r0KrTRutLWtRLIDya-vls0DeslpZuCb10cI5azkjNerbTniHIMfzB8sK8abkqmScfaBLDkDVYBqqoNdrkTRcg4L8imlLWMMuGw_kkXVSlC1aJbkYo3RO29NT9Pkh7mfE-1DLv2TmXwYqc-1H_-io1Ogt_NgRmoiGrpWq-ub79TYyT_46fEzOexMn_DLczwiv3-c35xdFle_Ln6enVwVVrJqKhCYU7gxlgvnRNdCXXcOu8qAMiCxkd1G1XXFTANCbZSDGphopWl4I_LjUhyR4_3cuxjuZ0yTHnyy2PdmxDAnzVsAzoUEkdFv_6HbMMcxX6c5VE0rVQ1Vpto9ZWNIKWKn72L2Gh81Z3onW2_1m2y9k62Z0ll2bv36vGDeDOheG1_sZuB0D2A28uAx6mQ9jhadj2gn7YJ_f8s_Wv-T4g</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Bonkhoff, Anna K.</creator><creator>Zimmermann, Eckart</creator><creator>Fink, Gereon R.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Veridical stimulus localization is linked to human area V5/MT+ activity</title><author>Bonkhoff, Anna K. ; Zimmermann, Eckart ; Fink, Gereon R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-e90d5ebac13dd3f8966fdef2a95a94e74fb56620a7935b5d9690384a717301643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Brain</topic><topic>Brain mapping</topic><topic>Compression</topic><topic>Eye</topic><topic>Eye movements</topic><topic>Female</topic><topic>fMRI</topic><topic>Functional magnetic resonance imaging</topic><topic>Human V5/MT+ deactivation</topic><topic>Humans</topic><topic>Information processing</topic><topic>Localization</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Masks</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Motion detection</topic><topic>Neuroimaging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Photic Stimulation</topic><topic>Saccadic eye movements</topic><topic>Space Perception - physiology</topic><topic>Spatial shift</topic><topic>Stimulus localization</topic><topic>Studies</topic><topic>Visual Cortex - physiology</topic><topic>Visual masking</topic><topic>Visual observation</topic><topic>Visual perception</topic><topic>Visual Perception - physiology</topic><topic>Visual stimuli</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonkhoff, Anna K.</creatorcontrib><creatorcontrib>Zimmermann, Eckart</creatorcontrib><creatorcontrib>Fink, Gereon R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonkhoff, Anna K.</au><au>Zimmermann, Eckart</au><au>Fink, Gereon R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Veridical stimulus localization is linked to human area V5/MT+ activity</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>156</volume><spage>377</spage><epage>387</epage><pages>377-387</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>How the brain represents visual space is an unsolved mystery. Spatial localization becomes particularly challenging when visual information processing is briefly disrupted, as in the case of saccadic eye movements, blinks, or visual masks. As we have recently reported, a compression of visual space, illustrated by displacements of shortly flashed stimuli, can be observed in the temporal vicinity of masking stimuli during ocular fixation (Zimmermann et al., 2013). We here aimed at investigating the neural mechanisms underlying these displacements using functional magnetic resonance imaging. On the behavioral level, we detected significant stimulus displacement when visual masks were simultaneously presented. At the neural level, we observed decreased human motion complex V5/MT+ activation associated with these displacements: When comparing trials with a perceived stimulus shift in space to trials of veridical perception of stimulus localization, human V5/MT+ was significantly less activated although no differences in perceived motion can account for this. Data suggest an important role of human V5/MT+ in the process of spatial localization of briefly presented objects and thus extend current concepts of the functions of human V5/MT+.
•Human V5/MT+ is involved in the veridical localization of shortly presented objects.•Spatial mislocalization of shortly presented objects can be linked to deactivation of human V5/MT+.•Masking stimuli may exert a suppressive influence on human V5/MT+.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28495637</pmid><doi>10.1016/j.neuroimage.2017.05.010</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Brain Brain mapping Compression Eye Eye movements Female fMRI Functional magnetic resonance imaging Human V5/MT+ deactivation Humans Information processing Localization Magnetic Resonance Imaging Male Masks Medical imaging Middle Aged Motion detection Neuroimaging NMR Nuclear magnetic resonance Photic Stimulation Saccadic eye movements Space Perception - physiology Spatial shift Stimulus localization Studies Visual Cortex - physiology Visual masking Visual observation Visual perception Visual Perception - physiology Visual stimuli Young Adult |
| title | Veridical stimulus localization is linked to human area V5/MT+ activity |
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