Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke
FABP4 (fatty acid-binding protein 4) is an intracellular lipid chaperone involved in coordination of lipid transportation and atherogenesis. This study aimed at observing the effect of FABP4 on the 3-month outcomes in Chinese patients with acute ischemic stroke. In a prospective multicenter observat...
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| Veröffentlicht in: | Stroke (1970) 2017-06, Vol.48 (6), p.1531-1538 |
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| container_title | Stroke (1970) |
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| creator | Tu, Wen-Jun Zeng, Xian-Wei Deng, Aijun Zhao, Sheng-Jie Luo, Ding-Zhen Ma, Guo-Zhao Wang, Hong Liu, Qiang |
| description | FABP4 (fatty acid-binding protein 4) is an intracellular lipid chaperone involved in coordination of lipid transportation and atherogenesis. This study aimed at observing the effect of FABP4 on the 3-month outcomes in Chinese patients with acute ischemic stroke.
In a prospective multicenter observational study, serum concentrations of FABP4 were on admission measured in plasma of 737 consecutive patients with acute ischemic stroke. Serum concentrations of FABP4, National Institutes of Health Stroke Scale score, and conventional risk factors were evaluated to determine their value to predict functional outcome and mortality within 3 months.
During follow-up, an unfavorable functional outcome was found in 260 patients (35.3%), and 94 patients (12.8%) died. In multivariate models comparing the third and fourth quartiles to the first quartile of FABP4, the concentrations of FABP4 were associated with poor functional outcome and mortality. Compared with the reference category (Q1-Q3), the concentrations of FABP4 in Q4 had a relative risk of 4.77 (95% confidence interval [CI], 2.02-8.15; |
| doi_str_mv | 10.1161/STROKEAHA.117.017128 |
| format | Article |
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In a prospective multicenter observational study, serum concentrations of FABP4 were on admission measured in plasma of 737 consecutive patients with acute ischemic stroke. Serum concentrations of FABP4, National Institutes of Health Stroke Scale score, and conventional risk factors were evaluated to determine their value to predict functional outcome and mortality within 3 months.
During follow-up, an unfavorable functional outcome was found in 260 patients (35.3%), and 94 patients (12.8%) died. In multivariate models comparing the third and fourth quartiles to the first quartile of FABP4, the concentrations of FABP4 were associated with poor functional outcome and mortality. Compared with the reference category (Q1-Q3), the concentrations of FABP4 in Q4 had a relative risk of 4.77 (95% confidence interval [CI], 2.02-8.15;
<0.001) for poor functional outcome and mortality (odds ratio, 6.15; 95% CI, 3.43-12.68) after adjusting for other significant outcome predictors in univariate logistic regression analysis. Receiver-operating characteristic curves to predict poor functional outcome and mortality demonstrated areas under the curve of FABP4 of 0.78 (95% CI, 0.75-0.82) and 0.83 (95% CI, 0.79-0.88), which improved the prognostic accuracy of National Institutes of Health Stroke Scale score with combined areas under the curve of 0.83 (95% CI, 0.76-0.89;
<0.01) and 0.86 (95% CI, 0.81-0.92), respectively.
Data show that FABP4 is a novel independent prognostic marker improving the currently used risk stratification of stroke patients.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.117.017128</identifier><identifier>PMID: 28487339</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Biomarkers - blood ; Brain Ischemia - blood ; Brain Ischemia - mortality ; Brain Ischemia - therapy ; China - epidemiology ; Fatty Acid-Binding Proteins - blood ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Patient Outcome Assessment ; Prognosis ; Risk Assessment - methods ; Stroke - blood ; Stroke - mortality ; Stroke - therapy</subject><ispartof>Stroke (1970), 2017-06, Vol.48 (6), p.1531-1538</ispartof><rights>2017 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-a4032b246849685d8096fc65c1178dd48bdfa0f7198d6c04c82da8ff716066ae3</citedby><cites>FETCH-LOGICAL-c353t-a4032b246849685d8096fc65c1178dd48bdfa0f7198d6c04c82da8ff716066ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28487339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tu, Wen-Jun</creatorcontrib><creatorcontrib>Zeng, Xian-Wei</creatorcontrib><creatorcontrib>Deng, Aijun</creatorcontrib><creatorcontrib>Zhao, Sheng-Jie</creatorcontrib><creatorcontrib>Luo, Ding-Zhen</creatorcontrib><creatorcontrib>Ma, Guo-Zhao</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Liu, Qiang</creatorcontrib><title>Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>FABP4 (fatty acid-binding protein 4) is an intracellular lipid chaperone involved in coordination of lipid transportation and atherogenesis. This study aimed at observing the effect of FABP4 on the 3-month outcomes in Chinese patients with acute ischemic stroke.
In a prospective multicenter observational study, serum concentrations of FABP4 were on admission measured in plasma of 737 consecutive patients with acute ischemic stroke. Serum concentrations of FABP4, National Institutes of Health Stroke Scale score, and conventional risk factors were evaluated to determine their value to predict functional outcome and mortality within 3 months.
During follow-up, an unfavorable functional outcome was found in 260 patients (35.3%), and 94 patients (12.8%) died. In multivariate models comparing the third and fourth quartiles to the first quartile of FABP4, the concentrations of FABP4 were associated with poor functional outcome and mortality. Compared with the reference category (Q1-Q3), the concentrations of FABP4 in Q4 had a relative risk of 4.77 (95% confidence interval [CI], 2.02-8.15;
<0.001) for poor functional outcome and mortality (odds ratio, 6.15; 95% CI, 3.43-12.68) after adjusting for other significant outcome predictors in univariate logistic regression analysis. Receiver-operating characteristic curves to predict poor functional outcome and mortality demonstrated areas under the curve of FABP4 of 0.78 (95% CI, 0.75-0.82) and 0.83 (95% CI, 0.79-0.88), which improved the prognostic accuracy of National Institutes of Health Stroke Scale score with combined areas under the curve of 0.83 (95% CI, 0.76-0.89;
<0.01) and 0.86 (95% CI, 0.81-0.92), respectively.
Data show that FABP4 is a novel independent prognostic marker improving the currently used risk stratification of stroke patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - mortality</subject><subject>Brain Ischemia - therapy</subject><subject>China - epidemiology</subject><subject>Fatty Acid-Binding Proteins - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Outcome Assessment</subject><subject>Prognosis</subject><subject>Risk Assessment - methods</subject><subject>Stroke - blood</subject><subject>Stroke - mortality</subject><subject>Stroke - therapy</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtOwzAQtBAIyuMPEPIRDgG_4tjHtKKAQFBBEcfItZ1iSJNiOyD-HlctPa1md2ZWMwCcYnSJMcdXL9Pnp_vr8rZMsLhEuMBE7IABzgnLGCdiFwwQojIjTMoDcBjCB0KIUJHvgwMimCgolQPwM3Je942Krp3DcTmcMHg-VjH-wlI7kw1da1aXie-idS1kF_AuQAUfu2_brLbztgvRaTh03UL5T-thYk2SnW1jgG8uviejPtok0-92kZgv0Xef9hjs1aoJ9mQzj8Dr-Ho6us0enm7uRuVDpmlOY6YYomRGGBdMcpEbgSSvNc91yiyMYWJmaoXqAkthuEZMC2KUqNOCI86VpUfgfO279N1Xb0OsFi5o2zSqtV0fKiykxBjTnCUqW1O170Lwtq6W3qVQvxVG1aryalt5gkW1rjzJzjYf-tnCmq3ov2P6B00mfB8</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Tu, Wen-Jun</creator><creator>Zeng, Xian-Wei</creator><creator>Deng, Aijun</creator><creator>Zhao, Sheng-Jie</creator><creator>Luo, Ding-Zhen</creator><creator>Ma, Guo-Zhao</creator><creator>Wang, Hong</creator><creator>Liu, Qiang</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke</title><author>Tu, Wen-Jun ; Zeng, Xian-Wei ; Deng, Aijun ; Zhao, Sheng-Jie ; Luo, Ding-Zhen ; Ma, Guo-Zhao ; Wang, Hong ; Liu, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-a4032b246849685d8096fc65c1178dd48bdfa0f7198d6c04c82da8ff716066ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - mortality</topic><topic>Brain Ischemia - therapy</topic><topic>China - epidemiology</topic><topic>Fatty Acid-Binding Proteins - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Outcome Assessment</topic><topic>Prognosis</topic><topic>Risk Assessment - methods</topic><topic>Stroke - blood</topic><topic>Stroke - mortality</topic><topic>Stroke - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tu, Wen-Jun</creatorcontrib><creatorcontrib>Zeng, Xian-Wei</creatorcontrib><creatorcontrib>Deng, Aijun</creatorcontrib><creatorcontrib>Zhao, Sheng-Jie</creatorcontrib><creatorcontrib>Luo, Ding-Zhen</creatorcontrib><creatorcontrib>Ma, Guo-Zhao</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Liu, Qiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tu, Wen-Jun</au><au>Zeng, Xian-Wei</au><au>Deng, Aijun</au><au>Zhao, Sheng-Jie</au><au>Luo, Ding-Zhen</au><au>Ma, Guo-Zhao</au><au>Wang, Hong</au><au>Liu, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2017-06</date><risdate>2017</risdate><volume>48</volume><issue>6</issue><spage>1531</spage><epage>1538</epage><pages>1531-1538</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>FABP4 (fatty acid-binding protein 4) is an intracellular lipid chaperone involved in coordination of lipid transportation and atherogenesis. This study aimed at observing the effect of FABP4 on the 3-month outcomes in Chinese patients with acute ischemic stroke.
In a prospective multicenter observational study, serum concentrations of FABP4 were on admission measured in plasma of 737 consecutive patients with acute ischemic stroke. Serum concentrations of FABP4, National Institutes of Health Stroke Scale score, and conventional risk factors were evaluated to determine their value to predict functional outcome and mortality within 3 months.
During follow-up, an unfavorable functional outcome was found in 260 patients (35.3%), and 94 patients (12.8%) died. In multivariate models comparing the third and fourth quartiles to the first quartile of FABP4, the concentrations of FABP4 were associated with poor functional outcome and mortality. Compared with the reference category (Q1-Q3), the concentrations of FABP4 in Q4 had a relative risk of 4.77 (95% confidence interval [CI], 2.02-8.15;
<0.001) for poor functional outcome and mortality (odds ratio, 6.15; 95% CI, 3.43-12.68) after adjusting for other significant outcome predictors in univariate logistic regression analysis. Receiver-operating characteristic curves to predict poor functional outcome and mortality demonstrated areas under the curve of FABP4 of 0.78 (95% CI, 0.75-0.82) and 0.83 (95% CI, 0.79-0.88), which improved the prognostic accuracy of National Institutes of Health Stroke Scale score with combined areas under the curve of 0.83 (95% CI, 0.76-0.89;
<0.01) and 0.86 (95% CI, 0.81-0.92), respectively.
Data show that FABP4 is a novel independent prognostic marker improving the currently used risk stratification of stroke patients.</abstract><cop>United States</cop><pmid>28487339</pmid><doi>10.1161/STROKEAHA.117.017128</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Biomarkers - blood Brain Ischemia - blood Brain Ischemia - mortality Brain Ischemia - therapy China - epidemiology Fatty Acid-Binding Proteins - blood Female Follow-Up Studies Humans Male Middle Aged Patient Outcome Assessment Prognosis Risk Assessment - methods Stroke - blood Stroke - mortality Stroke - therapy |
| title | Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke |
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