Insights on Heme Synthesis in the Malaria Parasite

The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglobin-heme. The heme pathway is dispensable for blood stages, but essential in the mosquito stages which do not acquire hemoglobin-heme. We propose that the blood stage parasites maintain a dynamic heme...

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Veröffentlicht in:	Trends in parasitology 2017-08, Vol.33 (8), p.583-586
Hauptverfasser:	Nagaraj, Viswanathan A, Padmanaban, Govindarajan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Culicidae - parasitology Gastroenterology and Hepatology Heme - biosynthesis Heme - genetics Heme - metabolism Host-Pathogen Interactions Humans Infectious Disease Life Cycle Stages - physiology Plasmodium falciparum - genetics Plasmodium falciparum - metabolism
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Zusammenfassung:	The malaria parasite has a functional heme-biosynthetic pathway, although it can access host hemoglobin-heme. The heme pathway is dispensable for blood stages, but essential in the mosquito stages which do not acquire hemoglobin-heme. We propose that the blood stage parasites maintain a dynamic heme pool through multiple back-up mechanisms.
ISSN:	1471-4922 1471-5007
DOI:	10.1016/j.pt.2017.04.005