Reduced anxiety-like behavior in transgenic rats with chronically overproduction of angiotensin-(1–7): Role of the Mas receptor

•Reduced anxiety-like behavior in transgenic rats with increased circulating Ang-(1–7).•PD123319 did not modify behavior in transgenic rats.•A779 reversed the reduced anxiety-like behavior in transgenic rats.•Activation of the Mas receptor exerts an anxiolytic-like effect. Angiotensin-(1–7) [Ang-(1–...

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Veröffentlicht in:	Behavioural brain research 2017-07, Vol.331, p.193-198
Hauptverfasser:	Kangussu, Lucas M., Almeida-Santos, Ana Flávia, Moreira, Fabrício A., Fontes, Marco A.P., Santos, Robson A.S., Aguiar, Daniele C., Campagnole-Santos, Maria José
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin I - metabolism Angiotensin II - pharmacology Angiotensin-(1–7) Animals Anxiety Anxiety - genetics Anxiety - metabolism AT2 receptor Behavior, Animal - drug effects Behavior, Animal - physiology Imidazoles - pharmacology Mas receptor MrgD receptor Peptide Fragments - metabolism Pyridines - pharmacology Rats, Sprague-Dawley Rats, Transgenic Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - metabolism Renin-Angiotensin System - drug effects Transgenic rats
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