Prolonged Survival Following Pig‐to‐Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade

Since the first attempt of pig‐to‐primate liver xenotransplantation (LXT) in 1968, survival has been limited. We evaluated a model utilizing α‐1,3‐galactosyltransferase knockout donors, continuous posttransplant infusion of human prothrombin concentrate complex, and immunosuppression including anti–...

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Veröffentlicht in:	American journal of transplantation 2017-08, Vol.17 (8), p.2178-2185
Hauptverfasser:	Shah, J. A., Patel, M. S., Elias, N., Navarro‐Alvarez, N., Rosales, I., Wilkinson, R. A., Louras, N. J., Hertl, M., Fishman, J. A., Colvin, R. B., Cosimi, A. B., Markmann, J. F., Sachs, D. H., Vagefi, P. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified basic (laboratory) research/science Blood Coagulation Factors - metabolism CD40 antigen Cholestasis Coagulation coagulation and hemostasis Coagulation factors fusion proteins and monoclonal antibodies: costimulation molecule specific Globulins graft survival Graft Survival - drug effects Graft Survival - immunology Hemorrhage immunosuppressant Immunosuppression Immunosuppressive Agents - pharmacology immunosuppressive regimens Liver Liver Transplantation - mortality Monkeys & apes Monoclonal antibodies Papio Pathology Plantar ulcers Prothrombin Survival Survival Rate Swine Tacrolimus Thrombotic microangiopathy Thymocytes Transplantation Transplantation, Heterologous Ulcers Xenografts xenotransplantation
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