Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1
Jackson and colleagues show that dendritic cells transit to the lumen of lymphatic vessels through hyaluronan-mediated interactions with the endothelial receptor LYVE-1. Trafficking of tissue dendritic cells (DCs) via lymph is critical for the generation of cellular immune responses in draining lymp...
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| Veröffentlicht in: | Nature immunology 2017-07, Vol.18 (7), p.762-770 |
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| container_title | Nature immunology |
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| creator | Johnson, Louise A Banerji, Suneale Lawrance, William Gileadi, Uzi Prota, Gennaro Holder, Kayla A Roshorm, Yaowaluck M Hanke, Tomáš Cerundolo, Vincenzo Gale, Nicholas W Jackson, David G |
| description | Jackson and colleagues show that dendritic cells transit to the lumen of lymphatic vessels through hyaluronan-mediated interactions with the endothelial receptor LYVE-1.
Trafficking of tissue dendritic cells (DCs) via lymph is critical for the generation of cellular immune responses in draining lymph nodes (LNs). In the current study we found that DCs docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1, in dynamic transmigratory-cup-like structures. Furthermore, we show that targeted deletion of the gene
Lyve1
, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8
+
T cell responses in skin-draining LNs. Our findings uncovered a previously unknown function for LYVE-1 and show that transit through the lymphatic network is initiated by the recognition of leukocyte-derived hyaluronan. |
| doi_str_mv | 10.1038/ni.3750 |
| format | Article |
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Trafficking of tissue dendritic cells (DCs) via lymph is critical for the generation of cellular immune responses in draining lymph nodes (LNs). In the current study we found that DCs docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1, in dynamic transmigratory-cup-like structures. Furthermore, we show that targeted deletion of the gene
Lyve1
, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8
+
T cell responses in skin-draining LNs. Our findings uncovered a previously unknown function for LYVE-1 and show that transit through the lymphatic network is initiated by the recognition of leukocyte-derived hyaluronan.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni.3750</identifier><identifier>PMID: 28504698</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>14 ; 14/19 ; 38 ; 45 ; 59 ; 631/250 ; 631/250/1617 ; 631/250/1617/2069 ; 631/80 ; 631/80/84 ; 64 ; 64/60 ; 82 ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Blood vessels ; CD8 antigen ; Cell Movement - immunology ; Clonal deletion ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Docking ; Endothelial Cells - metabolism ; Endothelium ; Endothelium, Lymphatic - cytology ; Endothelium, Lymphatic - metabolism ; Flow Cytometry ; G proteins ; Gene deletion ; Glycoproteins - genetics ; Glycoproteins - metabolism ; Homeostasis ; Humans ; Hyaluronic acid ; Hyaluronic Acid - metabolism ; Immune response ; Immune response (cell-mediated) ; Immunity, Cellular - immunology ; Immunology ; Infectious Diseases ; Inflammation ; Lymph nodes ; Lymph Nodes - immunology ; Lymphatic system ; Lymphatic vessels ; Lymphatic Vessels - metabolism ; Lymphocytes T ; Membrane Transport Proteins ; Mice ; Mice, Knockout ; Mice, Transgenic ; Protein transport ; Reverse Transcriptase Polymerase Chain Reaction ; Skin ; T cell receptors ; T-Lymphocytes - immunology ; Vesicular Transport Proteins - metabolism</subject><ispartof>Nature immunology, 2017-07, Vol.18 (7), p.762-770</ispartof><rights>Springer Nature America, Inc. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2017</rights><rights>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-2c7d2c80f7ce411bb0a700e6c187c09b83ae62130d1a5fad0b9a33f81f3ffce83</citedby><cites>FETCH-LOGICAL-c504t-2c7d2c80f7ce411bb0a700e6c187c09b83ae62130d1a5fad0b9a33f81f3ffce83</cites><orcidid>0000-0002-6076-9546 ; 0000-0002-4133-9364</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28504698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Louise A</creatorcontrib><creatorcontrib>Banerji, Suneale</creatorcontrib><creatorcontrib>Lawrance, William</creatorcontrib><creatorcontrib>Gileadi, Uzi</creatorcontrib><creatorcontrib>Prota, Gennaro</creatorcontrib><creatorcontrib>Holder, Kayla A</creatorcontrib><creatorcontrib>Roshorm, Yaowaluck M</creatorcontrib><creatorcontrib>Hanke, Tomáš</creatorcontrib><creatorcontrib>Cerundolo, Vincenzo</creatorcontrib><creatorcontrib>Gale, Nicholas W</creatorcontrib><creatorcontrib>Jackson, David G</creatorcontrib><title>Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>Jackson and colleagues show that dendritic cells transit to the lumen of lymphatic vessels through hyaluronan-mediated interactions with the endothelial receptor LYVE-1.
Trafficking of tissue dendritic cells (DCs) via lymph is critical for the generation of cellular immune responses in draining lymph nodes (LNs). In the current study we found that DCs docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1, in dynamic transmigratory-cup-like structures. Furthermore, we show that targeted deletion of the gene
Lyve1
, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8
+
T cell responses in skin-draining LNs. Our findings uncovered a previously unknown function for LYVE-1 and show that transit through the lymphatic network is initiated by the recognition of leukocyte-derived hyaluronan.</description><subject>14</subject><subject>14/19</subject><subject>38</subject><subject>45</subject><subject>59</subject><subject>631/250</subject><subject>631/250/1617</subject><subject>631/250/1617/2069</subject><subject>631/80</subject><subject>631/80/84</subject><subject>64</subject><subject>64/60</subject><subject>82</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood vessels</subject><subject>CD8 antigen</subject><subject>Cell Movement - immunology</subject><subject>Clonal deletion</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Docking</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelium</subject><subject>Endothelium, Lymphatic - cytology</subject><subject>Endothelium, Lymphatic - metabolism</subject><subject>Flow Cytometry</subject><subject>G proteins</subject><subject>Gene deletion</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - metabolism</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - metabolism</subject><subject>Immune response</subject><subject>Immune response (cell-mediated)</subject><subject>Immunity, Cellular - immunology</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Inflammation</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphatic system</subject><subject>Lymphatic vessels</subject><subject>Lymphatic Vessels - metabolism</subject><subject>Lymphocytes T</subject><subject>Membrane Transport Proteins</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Protein transport</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Skin</subject><subject>T cell receptors</subject><subject>T-Lymphocytes - 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immunology</topic><topic>Clonal deletion</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Docking</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelium</topic><topic>Endothelium, Lymphatic - cytology</topic><topic>Endothelium, Lymphatic - metabolism</topic><topic>Flow Cytometry</topic><topic>G proteins</topic><topic>Gene deletion</topic><topic>Glycoproteins - genetics</topic><topic>Glycoproteins - metabolism</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - metabolism</topic><topic>Immune response</topic><topic>Immune response (cell-mediated)</topic><topic>Immunity, Cellular - immunology</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Inflammation</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphatic system</topic><topic>Lymphatic vessels</topic><topic>Lymphatic Vessels - 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Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Louise A</au><au>Banerji, Suneale</au><au>Lawrance, William</au><au>Gileadi, Uzi</au><au>Prota, Gennaro</au><au>Holder, Kayla A</au><au>Roshorm, Yaowaluck M</au><au>Hanke, Tomáš</au><au>Cerundolo, Vincenzo</au><au>Gale, Nicholas W</au><au>Jackson, David G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>18</volume><issue>7</issue><spage>762</spage><epage>770</epage><pages>762-770</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>Jackson and colleagues show that dendritic cells transit to the lumen of lymphatic vessels through hyaluronan-mediated interactions with the endothelial receptor LYVE-1.
Trafficking of tissue dendritic cells (DCs) via lymph is critical for the generation of cellular immune responses in draining lymph nodes (LNs). In the current study we found that DCs docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1, in dynamic transmigratory-cup-like structures. Furthermore, we show that targeted deletion of the gene
Lyve1
, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8
+
T cell responses in skin-draining LNs. Our findings uncovered a previously unknown function for LYVE-1 and show that transit through the lymphatic network is initiated by the recognition of leukocyte-derived hyaluronan.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28504698</pmid><doi>10.1038/ni.3750</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6076-9546</orcidid><orcidid>https://orcid.org/0000-0002-4133-9364</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature immunology, 2017-07, Vol.18 (7), p.762-770 |
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| subjects | 14 14/19 38 45 59 631/250 631/250/1617 631/250/1617/2069 631/80 631/80/84 64 64/60 82 Animals Biomedical and Life Sciences Biomedicine Blood vessels CD8 antigen Cell Movement - immunology Clonal deletion Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Docking Endothelial Cells - metabolism Endothelium Endothelium, Lymphatic - cytology Endothelium, Lymphatic - metabolism Flow Cytometry G proteins Gene deletion Glycoproteins - genetics Glycoproteins - metabolism Homeostasis Humans Hyaluronic acid Hyaluronic Acid - metabolism Immune response Immune response (cell-mediated) Immunity, Cellular - immunology Immunology Infectious Diseases Inflammation Lymph nodes Lymph Nodes - immunology Lymphatic system Lymphatic vessels Lymphatic Vessels - metabolism Lymphocytes T Membrane Transport Proteins Mice Mice, Knockout Mice, Transgenic Protein transport Reverse Transcriptase Polymerase Chain Reaction Skin T cell receptors T-Lymphocytes - immunology Vesicular Transport Proteins - metabolism |
| title | Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1 |
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