Inhibiting Firefly Bioluminescence by Chalcones

Chalcone refers to an aromatic ketone and an enone that constitutes the central core for various important biological compounds in drug discovery. Moreover, the firefly luciferase (Fluc) as the bioluminescent reporter has been widely used in life science research and high-throughput screening (HTS)....

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Veröffentlicht in:	Analytical chemistry (Washington) 2017-06, Vol.89 (11), p.6099-6105
Hauptverfasser:	Zhang, Huateng, Su, Jing, Lin, Yuxin, Bai, Haixiu, Liu, Jiaxiang, Chen, Hui, Du, Lupei, Gu, Lichuan, Li, Minyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Assaying ATP Bioluminescence Chemistry Crystal structure Enzyme kinetics High-throughput screening In vitro methods and tests Inhibition Inhibitors Kinetics Mice Quenching Rodents Selectivity Simulation Transgenic mice
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