Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis
Objective This systematic review and meta‐analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment. Methods A literature search was performed for articles published in English using the 10 databases...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2018-01, Vol.33 (1), p.e1-e13 |
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| container_title | International journal of geriatric psychiatry |
| container_volume | 33 |
| creator | Cheng, Calvin Pak Wing Wong, Corine Sau Man Lee, Kelsey Kimyin Chan, Alfred Pui Kam Yeung, Jerry Wing Fai Chan, Wai Chi |
| description | Objective
This systematic review and meta‐analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment.
Methods
A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini‐Mental State Examination or the Alzheimer's Disease Assessment Scale‐cognitive subscale.
Results
Seven RCTs were included in the meta‐analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84).
Conclusions
High‐frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well‐tolerated alternative intervention for cognition. Copyright © 2017 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.4726 |
| format | Article |
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This systematic review and meta‐analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment.
Methods
A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini‐Mental State Examination or the Alzheimer's Disease Assessment Scale‐cognitive subscale.
Results
Seven RCTs were included in the meta‐analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84).
Conclusions
High‐frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well‐tolerated alternative intervention for cognition. Copyright © 2017 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.4726</identifier><identifier>PMID: 28493371</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Alzheimer Disease - physiopathology ; Alzheimer Disease - therapy ; Alzheimer's disease ; Clinical trials ; Cognition & reasoning ; Cognition - physiology ; Cognitive ability ; Cognitive Dysfunction - physiopathology ; Cognitive Dysfunction - therapy ; cognitive impairment ; dementia ; Geriatric psychiatry ; Geriatrics ; Humans ; Magnetic fields ; Meta-analysis ; Neurodegenerative diseases ; Nursing ; Older people ; Systematic review ; Transcranial magnetic stimulation ; Transcranial Magnetic Stimulation - methods</subject><ispartof>International journal of geriatric psychiatry, 2018-01, Vol.33 (1), p.e1-e13</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3496-8c83933dd9f7623f796d4a72a0504b9913ed99a9da0be28fd0b5bc511636a4b43</citedby><cites>FETCH-LOGICAL-c3496-8c83933dd9f7623f796d4a72a0504b9913ed99a9da0be28fd0b5bc511636a4b43</cites><orcidid>0000-0003-4457-1908 ; 0000-0002-7980-3126 ; 0000-0002-7324-0553 ; 0000-0003-3363-1004</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.4726$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.4726$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28493371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Calvin Pak Wing</creatorcontrib><creatorcontrib>Wong, Corine Sau Man</creatorcontrib><creatorcontrib>Lee, Kelsey Kimyin</creatorcontrib><creatorcontrib>Chan, Alfred Pui Kam</creatorcontrib><creatorcontrib>Yeung, Jerry Wing Fai</creatorcontrib><creatorcontrib>Chan, Wai Chi</creatorcontrib><title>Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description>Objective
This systematic review and meta‐analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment.
Methods
A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini‐Mental State Examination or the Alzheimer's Disease Assessment Scale‐cognitive subscale.
Results
Seven RCTs were included in the meta‐analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84).
Conclusions
High‐frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well‐tolerated alternative intervention for cognition. Copyright © 2017 John Wiley & Sons, Ltd.</description><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - therapy</subject><subject>Alzheimer's disease</subject><subject>Clinical trials</subject><subject>Cognition & reasoning</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cognitive Dysfunction - therapy</subject><subject>cognitive impairment</subject><subject>dementia</subject><subject>Geriatric psychiatry</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Magnetic fields</subject><subject>Meta-analysis</subject><subject>Neurodegenerative diseases</subject><subject>Nursing</subject><subject>Older people</subject><subject>Systematic review</subject><subject>Transcranial magnetic stimulation</subject><subject>Transcranial Magnetic Stimulation - methods</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9qFTEQxoNY7GkVfAIJeNObrcn-TbyT0lahYEG9XmZ3Z48pye6aZM9h73wEn6OP1Sdxtn8UBCEkF99vvsnMx9hrKU6lEOm77RRO8yotn7GNFFonUpblc7YRShVJmWbikB2FcCMEaVK9YIepynWWVXLDbs_7HtsY-NhzjxNGE80OefQwhJYuA5Y72A4ktDxE42YL0YwDp2Pc5McdOhziWt6O28Hca2bgaDv0duET0aQHvjfx-xNCDagWjF9L33PgYQkRHaw9PO4M7jkMHXcY4e7nLxjALsGEl-ygBxvw1eN7zL5dnH89-5hcfb78dPbhKmmzXJeJalVGw3Wd7iuava902eVQpSAKkTe0gAw7rUF3IBpMVd-JpmjaglaWlZA3eXbMTh58abofM4ZYOxNatBYGHOdQS6UrJfJSaELf_oPejLOn_xJFUKFEIau_hq0fQ_DY15M3DvxSS1Gv-dWUX73mR-ibR8O5cdj9AZ8CIyB5APbG4vJfo_ry-su94W9oMKlw</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Cheng, Calvin Pak Wing</creator><creator>Wong, Corine Sau Man</creator><creator>Lee, Kelsey Kimyin</creator><creator>Chan, Alfred Pui Kam</creator><creator>Yeung, Jerry Wing Fai</creator><creator>Chan, Wai Chi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4457-1908</orcidid><orcidid>https://orcid.org/0000-0002-7980-3126</orcidid><orcidid>https://orcid.org/0000-0002-7324-0553</orcidid><orcidid>https://orcid.org/0000-0003-3363-1004</orcidid></search><sort><creationdate>201801</creationdate><title>Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis</title><author>Cheng, Calvin Pak Wing ; Wong, Corine Sau Man ; Lee, Kelsey Kimyin ; Chan, Alfred Pui Kam ; Yeung, Jerry Wing Fai ; Chan, Wai Chi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3496-8c83933dd9f7623f796d4a72a0504b9913ed99a9da0be28fd0b5bc511636a4b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer Disease - therapy</topic><topic>Alzheimer's disease</topic><topic>Clinical trials</topic><topic>Cognition & reasoning</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cognitive Dysfunction - therapy</topic><topic>cognitive impairment</topic><topic>dementia</topic><topic>Geriatric psychiatry</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Magnetic fields</topic><topic>Meta-analysis</topic><topic>Neurodegenerative diseases</topic><topic>Nursing</topic><topic>Older people</topic><topic>Systematic review</topic><topic>Transcranial magnetic stimulation</topic><topic>Transcranial Magnetic Stimulation - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Calvin Pak Wing</creatorcontrib><creatorcontrib>Wong, Corine Sau Man</creatorcontrib><creatorcontrib>Lee, Kelsey Kimyin</creatorcontrib><creatorcontrib>Chan, Alfred Pui Kam</creatorcontrib><creatorcontrib>Yeung, Jerry Wing Fai</creatorcontrib><creatorcontrib>Chan, Wai Chi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Calvin Pak Wing</au><au>Wong, Corine Sau Man</au><au>Lee, Kelsey Kimyin</au><au>Chan, Alfred Pui Kam</au><au>Yeung, Jerry Wing Fai</au><au>Chan, Wai Chi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2018-01</date><risdate>2018</risdate><volume>33</volume><issue>1</issue><spage>e1</spage><epage>e13</epage><pages>e1-e13</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract>Objective
This systematic review and meta‐analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment.
Methods
A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini‐Mental State Examination or the Alzheimer's Disease Assessment Scale‐cognitive subscale.
Results
Seven RCTs were included in the meta‐analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84).
Conclusions
High‐frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well‐tolerated alternative intervention for cognition. Copyright © 2017 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28493371</pmid><doi>10.1002/gps.4726</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4457-1908</orcidid><orcidid>https://orcid.org/0000-0002-7980-3126</orcidid><orcidid>https://orcid.org/0000-0002-7324-0553</orcidid><orcidid>https://orcid.org/0000-0003-3363-1004</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of geriatric psychiatry, 2018-01, Vol.33 (1), p.e1-e13 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Alzheimer Disease - physiopathology Alzheimer Disease - therapy Alzheimer's disease Clinical trials Cognition & reasoning Cognition - physiology Cognitive ability Cognitive Dysfunction - physiopathology Cognitive Dysfunction - therapy cognitive impairment dementia Geriatric psychiatry Geriatrics Humans Magnetic fields Meta-analysis Neurodegenerative diseases Nursing Older people Systematic review Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods |
| title | Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis |
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