Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors
Background The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study...
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| Veröffentlicht in: | Pediatric diabetes 2018-02, Vol.19 (1), p.45-52 |
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| creator | Alías‐Hernández, Irene Galera‐Martínez, Rafael García‐García, Emilio Muñoz‐Vico, Francisco Javier Vázquez Lopez, María Ángeles Olvera‐Porcel, María Carmen Bonillo Perales, Antonio |
| description | Background
The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study its association with cardiovascular risk factors.
Materials and Methods
Population‐based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2.00 to 9.99 years old. Anthropometric measurements, blood pressure, and fasting blood samples were obtained, including fasting glucose, triglycerides, High Density Lipoprotein (HDL)‐cholesterol, and insulin. In addition, QUICKI and HOMA indices were calculated. Generalised additive models for location, scale and shape (GAMLSS) was used to calculate centiles curves and multivariate logistic regression analysis to assess factors associated with IR.
Results
A total of 654 subjects were included. Mean values obtained for insulinaemia, HOMA index, and QUICKI were 3.74 μIU/mL, 0.73, and 0.44, respectively, in the overall population and 3.32 μIU/mL, 0.64 and 0.46, respectively, in normal weight subjects. The main factor associated with IR was abdominal obesity (odds ratio [OR] 3.38 [95% CI 1.44‐7.94] in the subgroup aged 2.00‐5.99 years and OR 9.14 [3.42‐24.41] for those aged 6.00‐9.99 years). An increased risk of hyperglycaemia (P = 0.043), hypertriglyceridaemia (P |
| doi_str_mv | 10.1111/pedi.12533 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1897803411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1990736513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3583-6c7647f4632c731d74bb995624770a8bab03aaa4e8b526da2f87c539423216e23</originalsourceid><addsrcrecordid>eNpdkU1LAzEQhoMotn5c_AES8OKlNV-72XiTWrUg6EHBW5jNphLdZtdkF6m_3vTDHpzLvMw8zAzzInRGyZimuGpt5caUZZzvoSHlSo0yIYr9neZvA3QU4wchVCouDtGAFSIJSofoZ-ZjXzsPduEAg6-w2xRwsNHFDryxqYQn0BuIDjx-t94GqHELaS10wRncNm1fQ-caj-HdVpjhrsGU4KWFEK_xTYyNSWjqBBc_8RxM14R4gg7mUEd7us3H6PVu-jJ5GD0-3c8mN48jw7OCj3IjcyHnIufMSE4rKcpSqSxnQkoCRQkl4QAgbFFmLK-AzQtpMq4E44zmlvFjdLmZ24bmq7ex0wsXja1r8Lbpo6aFkgVZvSOhF__Qj6YPPl2nqVJE8jyjPFHnW6ovF7bSbXALCEv999UE0A3w7Wq73PUp0Su_9MovvfZLP09vZ2vFfwEruYeA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1990736513</pqid></control><display><type>article</type><title>Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Alías‐Hernández, Irene ; Galera‐Martínez, Rafael ; García‐García, Emilio ; Muñoz‐Vico, Francisco Javier ; Vázquez Lopez, María Ángeles ; Olvera‐Porcel, María Carmen ; Bonillo Perales, Antonio</creator><creatorcontrib>Alías‐Hernández, Irene ; Galera‐Martínez, Rafael ; García‐García, Emilio ; Muñoz‐Vico, Francisco Javier ; Vázquez Lopez, María Ángeles ; Olvera‐Porcel, María Carmen ; Bonillo Perales, Antonio</creatorcontrib><description>Background
The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study its association with cardiovascular risk factors.
Materials and Methods
Population‐based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2.00 to 9.99 years old. Anthropometric measurements, blood pressure, and fasting blood samples were obtained, including fasting glucose, triglycerides, High Density Lipoprotein (HDL)‐cholesterol, and insulin. In addition, QUICKI and HOMA indices were calculated. Generalised additive models for location, scale and shape (GAMLSS) was used to calculate centiles curves and multivariate logistic regression analysis to assess factors associated with IR.
Results
A total of 654 subjects were included. Mean values obtained for insulinaemia, HOMA index, and QUICKI were 3.74 μIU/mL, 0.73, and 0.44, respectively, in the overall population and 3.32 μIU/mL, 0.64 and 0.46, respectively, in normal weight subjects. The main factor associated with IR was abdominal obesity (odds ratio [OR] 3.38 [95% CI 1.44‐7.94] in the subgroup aged 2.00‐5.99 years and OR 9.14 [3.42‐24.41] for those aged 6.00‐9.99 years). An increased risk of hyperglycaemia (P = 0.043), hypertriglyceridaemia (P < .001), and HDL < p10 (P = 0.021) was described among children aged 2.00 to 5.99 years with IR, and among those aged 6.00 to 9.99 years, IR was associated with an increased risk of hypertriglyceridaemia (P < .001).
Conclusion
Abdominal obesity was the main factor associated with IR. Metabolic changes associated with IR seem to be present from early stages of life, which highlights the importance of the prevention, early diagnosis and treatment of obesity.</description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1111/pedi.12533</identifier><identifier>PMID: 28493411</identifier><language>eng</language><publisher>Former Munksgaard: John Wiley & Sons A/S</publisher><subject>Blood pressure ; Cardiovascular diseases ; cardiovascular risk factors ; Child ; Child, Preschool ; Children ; Cholesterol ; Fasting ; Female ; High density lipoprotein ; Homeostasis ; Humans ; Hyperglycemia ; Insulin ; Insulin - blood ; Insulin Resistance ; insulinaemia ; Laboratory testing ; Male ; Obesity ; Population ; Population studies ; Reference Values ; Risk Factors ; Triglycerides ; White people</subject><ispartof>Pediatric diabetes, 2018-02, Vol.19 (1), p.45-52</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3583-6c7647f4632c731d74bb995624770a8bab03aaa4e8b526da2f87c539423216e23</citedby><orcidid>0000-0001-6003-3961</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpedi.12533$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpedi.12533$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28493411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alías‐Hernández, Irene</creatorcontrib><creatorcontrib>Galera‐Martínez, Rafael</creatorcontrib><creatorcontrib>García‐García, Emilio</creatorcontrib><creatorcontrib>Muñoz‐Vico, Francisco Javier</creatorcontrib><creatorcontrib>Vázquez Lopez, María Ángeles</creatorcontrib><creatorcontrib>Olvera‐Porcel, María Carmen</creatorcontrib><creatorcontrib>Bonillo Perales, Antonio</creatorcontrib><title>Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description>Background
The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study its association with cardiovascular risk factors.
Materials and Methods
Population‐based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2.00 to 9.99 years old. Anthropometric measurements, blood pressure, and fasting blood samples were obtained, including fasting glucose, triglycerides, High Density Lipoprotein (HDL)‐cholesterol, and insulin. In addition, QUICKI and HOMA indices were calculated. Generalised additive models for location, scale and shape (GAMLSS) was used to calculate centiles curves and multivariate logistic regression analysis to assess factors associated with IR.
Results
A total of 654 subjects were included. Mean values obtained for insulinaemia, HOMA index, and QUICKI were 3.74 μIU/mL, 0.73, and 0.44, respectively, in the overall population and 3.32 μIU/mL, 0.64 and 0.46, respectively, in normal weight subjects. The main factor associated with IR was abdominal obesity (odds ratio [OR] 3.38 [95% CI 1.44‐7.94] in the subgroup aged 2.00‐5.99 years and OR 9.14 [3.42‐24.41] for those aged 6.00‐9.99 years). An increased risk of hyperglycaemia (P = 0.043), hypertriglyceridaemia (P < .001), and HDL < p10 (P = 0.021) was described among children aged 2.00 to 5.99 years with IR, and among those aged 6.00 to 9.99 years, IR was associated with an increased risk of hypertriglyceridaemia (P < .001).
Conclusion
Abdominal obesity was the main factor associated with IR. Metabolic changes associated with IR seem to be present from early stages of life, which highlights the importance of the prevention, early diagnosis and treatment of obesity.</description><subject>Blood pressure</subject><subject>Cardiovascular diseases</subject><subject>cardiovascular risk factors</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Cholesterol</subject><subject>Fasting</subject><subject>Female</subject><subject>High density lipoprotein</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>insulinaemia</subject><subject>Laboratory testing</subject><subject>Male</subject><subject>Obesity</subject><subject>Population</subject><subject>Population studies</subject><subject>Reference Values</subject><subject>Risk Factors</subject><subject>Triglycerides</subject><subject>White people</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1LAzEQhoMotn5c_AES8OKlNV-72XiTWrUg6EHBW5jNphLdZtdkF6m_3vTDHpzLvMw8zAzzInRGyZimuGpt5caUZZzvoSHlSo0yIYr9neZvA3QU4wchVCouDtGAFSIJSofoZ-ZjXzsPduEAg6-w2xRwsNHFDryxqYQn0BuIDjx-t94GqHELaS10wRncNm1fQ-caj-HdVpjhrsGU4KWFEK_xTYyNSWjqBBc_8RxM14R4gg7mUEd7us3H6PVu-jJ5GD0-3c8mN48jw7OCj3IjcyHnIufMSE4rKcpSqSxnQkoCRQkl4QAgbFFmLK-AzQtpMq4E44zmlvFjdLmZ24bmq7ex0wsXja1r8Lbpo6aFkgVZvSOhF__Qj6YPPl2nqVJE8jyjPFHnW6ovF7bSbXALCEv999UE0A3w7Wq73PUp0Su_9MovvfZLP09vZ2vFfwEruYeA</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Alías‐Hernández, Irene</creator><creator>Galera‐Martínez, Rafael</creator><creator>García‐García, Emilio</creator><creator>Muñoz‐Vico, Francisco Javier</creator><creator>Vázquez Lopez, María Ángeles</creator><creator>Olvera‐Porcel, María Carmen</creator><creator>Bonillo Perales, Antonio</creator><general>John Wiley & Sons A/S</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6003-3961</orcidid></search><sort><creationdate>201802</creationdate><title>Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors</title><author>Alías‐Hernández, Irene ; Galera‐Martínez, Rafael ; García‐García, Emilio ; Muñoz‐Vico, Francisco Javier ; Vázquez Lopez, María Ángeles ; Olvera‐Porcel, María Carmen ; Bonillo Perales, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3583-6c7647f4632c731d74bb995624770a8bab03aaa4e8b526da2f87c539423216e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Blood pressure</topic><topic>Cardiovascular diseases</topic><topic>cardiovascular risk factors</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Cholesterol</topic><topic>Fasting</topic><topic>Female</topic><topic>High density lipoprotein</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>insulinaemia</topic><topic>Laboratory testing</topic><topic>Male</topic><topic>Obesity</topic><topic>Population</topic><topic>Population studies</topic><topic>Reference Values</topic><topic>Risk Factors</topic><topic>Triglycerides</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alías‐Hernández, Irene</creatorcontrib><creatorcontrib>Galera‐Martínez, Rafael</creatorcontrib><creatorcontrib>García‐García, Emilio</creatorcontrib><creatorcontrib>Muñoz‐Vico, Francisco Javier</creatorcontrib><creatorcontrib>Vázquez Lopez, María Ángeles</creatorcontrib><creatorcontrib>Olvera‐Porcel, María Carmen</creatorcontrib><creatorcontrib>Bonillo Perales, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alías‐Hernández, Irene</au><au>Galera‐Martínez, Rafael</au><au>García‐García, Emilio</au><au>Muñoz‐Vico, Francisco Javier</au><au>Vázquez Lopez, María Ángeles</au><au>Olvera‐Porcel, María Carmen</au><au>Bonillo Perales, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2018-02</date><risdate>2018</risdate><volume>19</volume><issue>1</issue><spage>45</spage><epage>52</epage><pages>45-52</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract>Background
The aim of this study is to determine values of insulinaemia, homeostasis model assessment (HOMA) index and quantitative insulin sensitivity check index (QUICKI) among a population of prepubertal Caucasian children, to analyse factors associated with insulin resistance (IR), and to study its association with cardiovascular risk factors.
Materials and Methods
Population‐based study conducted on a randomly selected sample of prepubescent Caucasian subjects aged 2.00 to 9.99 years old. Anthropometric measurements, blood pressure, and fasting blood samples were obtained, including fasting glucose, triglycerides, High Density Lipoprotein (HDL)‐cholesterol, and insulin. In addition, QUICKI and HOMA indices were calculated. Generalised additive models for location, scale and shape (GAMLSS) was used to calculate centiles curves and multivariate logistic regression analysis to assess factors associated with IR.
Results
A total of 654 subjects were included. Mean values obtained for insulinaemia, HOMA index, and QUICKI were 3.74 μIU/mL, 0.73, and 0.44, respectively, in the overall population and 3.32 μIU/mL, 0.64 and 0.46, respectively, in normal weight subjects. The main factor associated with IR was abdominal obesity (odds ratio [OR] 3.38 [95% CI 1.44‐7.94] in the subgroup aged 2.00‐5.99 years and OR 9.14 [3.42‐24.41] for those aged 6.00‐9.99 years). An increased risk of hyperglycaemia (P = 0.043), hypertriglyceridaemia (P < .001), and HDL < p10 (P = 0.021) was described among children aged 2.00 to 5.99 years with IR, and among those aged 6.00 to 9.99 years, IR was associated with an increased risk of hypertriglyceridaemia (P < .001).
Conclusion
Abdominal obesity was the main factor associated with IR. Metabolic changes associated with IR seem to be present from early stages of life, which highlights the importance of the prevention, early diagnosis and treatment of obesity.</abstract><cop>Former Munksgaard</cop><pub>John Wiley & Sons A/S</pub><pmid>28493411</pmid><doi>10.1111/pedi.12533</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6003-3961</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood pressure Cardiovascular diseases cardiovascular risk factors Child Child, Preschool Children Cholesterol Fasting Female High density lipoprotein Homeostasis Humans Hyperglycemia Insulin Insulin - blood Insulin Resistance insulinaemia Laboratory testing Male Obesity Population Population studies Reference Values Risk Factors Triglycerides White people |
| title | Insulinaemia and insulin resistance in Caucasian general paediatric population aged 2 to 10 years: Associated risk factors |
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