The importance of combined 24‐hour multichannel intraluminal impedance–pH monitoring in the evaluation of children with suspected laryngopharyngeal reflux
Objective The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance–pH (MII‐pH) monitoring in children with suspected laryngopharyngeal reflux (LPR). Design, setting and participants A prospective study including children in whom, due to LPR s...
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| Veröffentlicht in: | Clinical otolaryngology 2017-06, Vol.42 (3), p.544-549 |
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| creator | Pavić, I. Babić, I. Čepin Bogović, J. Hojsak, I. |
| description | Objective
The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance–pH (MII‐pH) monitoring in children with suspected laryngopharyngeal reflux (LPR).
Design, setting and participants
A prospective study including children in whom, due to LPR suggestive symptoms, MII‐pH monitoring was performed at tertiary medical centre from February 2012 to July 2015.
Interventions
All included children underwent same diagnostic protocol which included examination by single pulmonologist and ENT specialist and underwent 24‐hour MII‐pH monitoring.
Main outcomes
Primary outcome was to determine MII‐pH characteristics of the children in whom LPR was suspected based on symptoms and ENT examination.
Results
One hundred and four patients (mean age 8.9 years; range 0.4–17.9 years; male/female 57/47) participated in the study. In children with signs and symptoms suggestive of LPR, MII‐pH monitoring found the median incidence of proximal gastro‐oesophageal reflux (GER) of 15 (range 0–129), proximal acidic GER of 6.5 (range 0–66) and weakly acidic GER of 5 (range 0–102). There were significant positive correlations between the number of GER (proximal total, acidic and weakly acid) with Reflux Finding Score, Reflux Symptom Index and presence of eosinophils in nasal swabs. The only endoscopy ENT finding which significantly correlated with total proximal GER, acid proximal GER and weakly acidic proximal GER was arytenoid hyperaemia.
Conclusion
Both acid and non‐acid reflux seem to have a significant role in the pathogenesis of LPR. |
| doi_str_mv | 10.1111/coa.12766 |
| format | Article |
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The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance–pH (MII‐pH) monitoring in children with suspected laryngopharyngeal reflux (LPR).
Design, setting and participants
A prospective study including children in whom, due to LPR suggestive symptoms, MII‐pH monitoring was performed at tertiary medical centre from February 2012 to July 2015.
Interventions
All included children underwent same diagnostic protocol which included examination by single pulmonologist and ENT specialist and underwent 24‐hour MII‐pH monitoring.
Main outcomes
Primary outcome was to determine MII‐pH characteristics of the children in whom LPR was suspected based on symptoms and ENT examination.
Results
One hundred and four patients (mean age 8.9 years; range 0.4–17.9 years; male/female 57/47) participated in the study. In children with signs and symptoms suggestive of LPR, MII‐pH monitoring found the median incidence of proximal gastro‐oesophageal reflux (GER) of 15 (range 0–129), proximal acidic GER of 6.5 (range 0–66) and weakly acidic GER of 5 (range 0–102). There were significant positive correlations between the number of GER (proximal total, acidic and weakly acid) with Reflux Finding Score, Reflux Symptom Index and presence of eosinophils in nasal swabs. The only endoscopy ENT finding which significantly correlated with total proximal GER, acid proximal GER and weakly acidic proximal GER was arytenoid hyperaemia.
Conclusion
Both acid and non‐acid reflux seem to have a significant role in the pathogenesis of LPR.</description><identifier>ISSN: 1749-4478</identifier><identifier>EISSN: 1749-4486</identifier><identifier>DOI: 10.1111/coa.12766</identifier><identifier>PMID: 27727523</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acids ; Adolescent ; Child ; Child, Preschool ; Electric Impedance ; Esophageal pH Monitoring - methods ; Female ; Follow-Up Studies ; Humans ; Hydrogen-Ion Concentration ; Infant ; Laryngopharyngeal Reflux - diagnosis ; Laryngopharyngeal Reflux - metabolism ; Laryngopharyngeal Reflux - physiopathology ; Male ; Prospective Studies ; Reproducibility of Results ; Time Factors</subject><ispartof>Clinical otolaryngology, 2017-06, Vol.42 (3), p.544-549</ispartof><rights>2016 John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons Ltd.</rights><rights>2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3866-a897825b1fd87fd93095bc5b4e919bf11363eba7987a229606f88d4a6add5ebd3</citedby><cites>FETCH-LOGICAL-c3866-a897825b1fd87fd93095bc5b4e919bf11363eba7987a229606f88d4a6add5ebd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcoa.12766$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcoa.12766$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27727523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pavić, I.</creatorcontrib><creatorcontrib>Babić, I.</creatorcontrib><creatorcontrib>Čepin Bogović, J.</creatorcontrib><creatorcontrib>Hojsak, I.</creatorcontrib><title>The importance of combined 24‐hour multichannel intraluminal impedance–pH monitoring in the evaluation of children with suspected laryngopharyngeal reflux</title><title>Clinical otolaryngology</title><addtitle>Clin Otolaryngol</addtitle><description>Objective
The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance–pH (MII‐pH) monitoring in children with suspected laryngopharyngeal reflux (LPR).
Design, setting and participants
A prospective study including children in whom, due to LPR suggestive symptoms, MII‐pH monitoring was performed at tertiary medical centre from February 2012 to July 2015.
Interventions
All included children underwent same diagnostic protocol which included examination by single pulmonologist and ENT specialist and underwent 24‐hour MII‐pH monitoring.
Main outcomes
Primary outcome was to determine MII‐pH characteristics of the children in whom LPR was suspected based on symptoms and ENT examination.
Results
One hundred and four patients (mean age 8.9 years; range 0.4–17.9 years; male/female 57/47) participated in the study. In children with signs and symptoms suggestive of LPR, MII‐pH monitoring found the median incidence of proximal gastro‐oesophageal reflux (GER) of 15 (range 0–129), proximal acidic GER of 6.5 (range 0–66) and weakly acidic GER of 5 (range 0–102). There were significant positive correlations between the number of GER (proximal total, acidic and weakly acid) with Reflux Finding Score, Reflux Symptom Index and presence of eosinophils in nasal swabs. The only endoscopy ENT finding which significantly correlated with total proximal GER, acid proximal GER and weakly acidic proximal GER was arytenoid hyperaemia.
Conclusion
Both acid and non‐acid reflux seem to have a significant role in the pathogenesis of LPR.</description><subject>Acids</subject><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Electric Impedance</subject><subject>Esophageal pH Monitoring - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Infant</subject><subject>Laryngopharyngeal Reflux - diagnosis</subject><subject>Laryngopharyngeal Reflux - metabolism</subject><subject>Laryngopharyngeal Reflux - physiopathology</subject><subject>Male</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Time Factors</subject><issn>1749-4478</issn><issn>1749-4486</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkbFuFDEQhlcRKAkhRV4AWaKB4hLb613bZXQCghQpTahXXns268hrL7aXkC6PgETPw-VJ8N2FFEhIuBkX33yjmb-qTgg-JeWd6aBOCeVtu1cdEs7kijHRvnj-c3FQvUrpFmNWY072qwPKOeUNrQ-rX9cjIDvNIWblNaAwIB2m3nowiLLHhx9jWCKaFpetHpX34JD1OSq3TNYrt2kFs-l8fPg5X6ApeJtDtP6mYCgXN3wrrMo2-K17tM5E8OjO5hGlJc2gcxnlVLz3N2EetxWKOMLglu-vq5eDcgmOn-pR9eXjh-v1xery6tPn9fnlSteibVdKSC5o05PBCD4YWWPZ9LrpGUgi-4GQuq2hV1wKriiVLW4HIQxTrTKmgd7UR9W7nXeO4esCKXeTTRqcUx7CkjpSBpRJkjX_gdYNw5RIWdC3f6G35ZrlbFshllRKQQr1fkfpGFIqe3dztFM5REdwt8m3K_l223wL--bJuPQTmGfyT6AFONsBd9bB_b9N3frqfKf8DWaItAs</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Pavić, I.</creator><creator>Babić, I.</creator><creator>Čepin Bogović, J.</creator><creator>Hojsak, I.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>201706</creationdate><title>The importance of combined 24‐hour multichannel intraluminal impedance–pH monitoring in the evaluation of children with suspected laryngopharyngeal reflux</title><author>Pavić, I. ; Babić, I. ; Čepin Bogović, J. ; Hojsak, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3866-a897825b1fd87fd93095bc5b4e919bf11363eba7987a229606f88d4a6add5ebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Electric Impedance</topic><topic>Esophageal pH Monitoring - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Infant</topic><topic>Laryngopharyngeal Reflux - diagnosis</topic><topic>Laryngopharyngeal Reflux - metabolism</topic><topic>Laryngopharyngeal Reflux - physiopathology</topic><topic>Male</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pavić, I.</creatorcontrib><creatorcontrib>Babić, I.</creatorcontrib><creatorcontrib>Čepin Bogović, J.</creatorcontrib><creatorcontrib>Hojsak, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Clinical otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pavić, I.</au><au>Babić, I.</au><au>Čepin Bogović, J.</au><au>Hojsak, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The importance of combined 24‐hour multichannel intraluminal impedance–pH monitoring in the evaluation of children with suspected laryngopharyngeal reflux</atitle><jtitle>Clinical otolaryngology</jtitle><addtitle>Clin Otolaryngol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>42</volume><issue>3</issue><spage>544</spage><epage>549</epage><pages>544-549</pages><issn>1749-4478</issn><eissn>1749-4486</eissn><abstract>Objective
The aim of this study was to investigate the diagnostic usefulness of combined multichannel intraluminal impedance–pH (MII‐pH) monitoring in children with suspected laryngopharyngeal reflux (LPR).
Design, setting and participants
A prospective study including children in whom, due to LPR suggestive symptoms, MII‐pH monitoring was performed at tertiary medical centre from February 2012 to July 2015.
Interventions
All included children underwent same diagnostic protocol which included examination by single pulmonologist and ENT specialist and underwent 24‐hour MII‐pH monitoring.
Main outcomes
Primary outcome was to determine MII‐pH characteristics of the children in whom LPR was suspected based on symptoms and ENT examination.
Results
One hundred and four patients (mean age 8.9 years; range 0.4–17.9 years; male/female 57/47) participated in the study. In children with signs and symptoms suggestive of LPR, MII‐pH monitoring found the median incidence of proximal gastro‐oesophageal reflux (GER) of 15 (range 0–129), proximal acidic GER of 6.5 (range 0–66) and weakly acidic GER of 5 (range 0–102). There were significant positive correlations between the number of GER (proximal total, acidic and weakly acid) with Reflux Finding Score, Reflux Symptom Index and presence of eosinophils in nasal swabs. The only endoscopy ENT finding which significantly correlated with total proximal GER, acid proximal GER and weakly acidic proximal GER was arytenoid hyperaemia.
Conclusion
Both acid and non‐acid reflux seem to have a significant role in the pathogenesis of LPR.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27727523</pmid><doi>10.1111/coa.12766</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical otolaryngology, 2017-06, Vol.42 (3), p.544-549 |
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| language | eng |
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| source | Access via Wiley Online Library; MEDLINE |
| subjects | Acids Adolescent Child Child, Preschool Electric Impedance Esophageal pH Monitoring - methods Female Follow-Up Studies Humans Hydrogen-Ion Concentration Infant Laryngopharyngeal Reflux - diagnosis Laryngopharyngeal Reflux - metabolism Laryngopharyngeal Reflux - physiopathology Male Prospective Studies Reproducibility of Results Time Factors |
| title | The importance of combined 24‐hour multichannel intraluminal impedance–pH monitoring in the evaluation of children with suspected laryngopharyngeal reflux |
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