Function of heterochromatin protein 1 during DNA repair
This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin,...
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| Veröffentlicht in: | Protoplasma 2017-05, Vol.254 (3), p.1233-1240 |
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| creator | Bártová, Eva Malyšková, Barbora Komůrková, Denisa Legartová, Soňa Suchánková, Jana Krejčí, Jana Kozubek, Stanislav |
| description | This review focuses on the function of heterochromatin protein HP1 in response to DNA damage. We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin, and HP1α and HP1β in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1α is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1α protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1β protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. Taken together, these results indicate that the function of HP1 after DNA injury depends strongly on the kinetics of other DNA repair-related factors and their post-translational modifications, such as the phosphorylation of Kap-1. |
| doi_str_mv | 10.1007/s00709-017-1090-3 |
| format | Article |
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We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin, and HP1α and HP1β in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1α is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1α protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1β protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. 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We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin, and HP1α and HP1β in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1α is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1α protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1β protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. Taken together, these results indicate that the function of HP1 after DNA injury depends strongly on the kinetics of other DNA repair-related factors and their post-translational modifications, such as the phosphorylation of Kap-1.</description><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Chromatin - metabolism</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>DNA Damage - genetics</subject><subject>DNA Repair - genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Plant Sciences</subject><subject>Proliferating Cell Nuclear Antigen - metabolism</subject><subject>Protein Processing, Post-Translational</subject><subject>Repressor Proteins - metabolism</subject><subject>Review Article</subject><subject>Tripartite Motif-Containing Protein 28</subject><subject>Zoology</subject><issn>0033-183X</issn><issn>1615-6102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUtLAzEUhYMoWh8_wI0MuHEzem_u5LUUtSqIbhTchTST2pF2piYzC_-9KVURQXBz7-Y75z4OY4cIpwigzlIuYEpAVSIYKGmDjVCiKCUC32QjAKISNT3vsN2UXgFAcBDbbIdrTjKLR0yNh9b3TdcW3bSYhT7Ezs9it3B90xbL2PUhdyzqITbtS3F5f17EsHRN3GdbUzdP4eCz77Gn8dXjxU1593B9e3F-V_pKYV9KKYzyigNNDIB3nqQhqDUGI2hqAorKO1VrT8R9pUE54Zzz2hDVVZBIe-xk7Zt3eRtC6u2iST7M564N3ZAsaqNIV4TiH6jiQglZyYwe_0JfuyG2-ZBMaa61EFBlCteUj11KMUztMjYLF98tgl0FYNcB2ByAXQVgKWuOPp2HySLU34qvj2eAr4G0XL00xB-j_3T9AB-1jQY</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Bártová, Eva</creator><creator>Malyšková, Barbora</creator><creator>Komůrková, Denisa</creator><creator>Legartová, Soňa</creator><creator>Suchánková, Jana</creator><creator>Krejčí, Jana</creator><creator>Kozubek, Stanislav</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20170501</creationdate><title>Function of heterochromatin protein 1 during DNA repair</title><author>Bártová, Eva ; 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We specifically outline the regulatory mechanisms in which HP1 and its interacting partners are involved. HP1 protein subtypes (HP1α, HP1β, and HP1γ) are the main components of constitutive heterochromatin, and HP1α and HP1β in particular are responsible for heterochromatin maintenance. The recruitment of these proteins to DNA lesions is also important from the perspective of proper DNA repair mechanisms. For example, HP1α is necessary for the binding of the main DNA damage-related protein 53BP1 at DNA repair foci, which are positive not only for the HP1α protein but also for the RAD51 protein, a component of DNA repair machinery. The HP1β protein also appears in monomeric form in DNA lesions together with the evolutionarily well-conserved protein called proliferating cell nuclear antigen (PCNA). The role of HP1 in DNA lesions is also mediated via the Kap1 transcription repressor. Taken together, these results indicate that the function of HP1 after DNA injury depends strongly on the kinetics of other DNA repair-related factors and their post-translational modifications, such as the phosphorylation of Kap-1.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>28236007</pmid><doi>10.1007/s00709-017-1090-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Cell Biology Chromatin - metabolism Chromosomal Proteins, Non-Histone - metabolism DNA Damage - genetics DNA Repair - genetics Humans Life Sciences Plant Sciences Proliferating Cell Nuclear Antigen - metabolism Protein Processing, Post-Translational Repressor Proteins - metabolism Review Article Tripartite Motif-Containing Protein 28 Zoology |
| title | Function of heterochromatin protein 1 during DNA repair |
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