No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome
Purpose To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS). Methods Thirty-seven women with PCOS and 41 controls matched for body mass in...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2015-05, Vol.291 (5), p.1075-1080 |
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| creator | Abali, Remzi Tasdemir, Nicel Alpsoy, Seref Tasdemir, Ufuk Göker Guzel, Savas Yuksel, Mehmet Aytac Temel Yuksel, Ilkbal Yilmaz, Murat |
| description | Purpose
To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS).
Methods
Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups.
Results
The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 ± 2.29 vs. 10.22 ± 2.25 pmol/L,
P
= 0.026). The mean CIMT was higher in PCOS group than control group (0.52 ± 0.058 vs. 0.45 ± 0.059 mm,
P
|
| doi_str_mv | 10.1007/s00404-014-3499-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1897384294</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1897384294</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-dc1f36fa6068c753e15f698053b8ddc941b89beb3f0e86c2e1f48a432c227cf83</originalsourceid><addsrcrecordid>eNqFkc1u1TAQhS1ERS-FB2CDLLFhEzr-ie0sUVV-pIpuYG0lzoSbKte-2A5XeQseGYcUkJBQVx5pvnOsM4eQFwzeMAB9mQAkyAqYrIRsmko_IjsmBa9AM_aY7KBZZ1D6nDxN6Q6AcWPUE3LOa26g1nJHfnwKNOLU5jH4tB-PtMN8QvQ0pIzhGEPGrxhHT13wDn2OG0lb31P0fch7nMZ2ov2Shtm7dUkL7YOvQocJ6SkcittpzPtfmnUIc6bHMC1uSXl0NHxv40LT4vtY2GfkbGinhM_v3wvy5d3156sP1c3t-49Xb28qJ3Wdq96xQaihVaCM07VAVg-qKaFEZ_reNZJ1pumwEwOgUY4jG6Rpy20c59oNRlyQ15tvyfhtxpTtYUwOp6n1GOZkmWm0MJI38mFUKam1UmJFX_2D3oU5-hLEcq5YLUADKxTbKBdDShEHe4zjoVzBMrBrs3Zr1pZm7dqs1UXz8t557g7Y_1H8rrIAfANSWflS2t-v_-_6E_6Qsc4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261530701</pqid></control><display><type>article</type><title>No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Abali, Remzi ; Tasdemir, Nicel ; Alpsoy, Seref ; Tasdemir, Ufuk Göker ; Guzel, Savas ; Yuksel, Mehmet Aytac ; Temel Yuksel, Ilkbal ; Yilmaz, Murat</creator><creatorcontrib>Abali, Remzi ; Tasdemir, Nicel ; Alpsoy, Seref ; Tasdemir, Ufuk Göker ; Guzel, Savas ; Yuksel, Mehmet Aytac ; Temel Yuksel, Ilkbal ; Yilmaz, Murat</creatorcontrib><description>Purpose
To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS).
Methods
Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups.
Results
The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 ± 2.29 vs. 10.22 ± 2.25 pmol/L,
P
= 0.026). The mean CIMT was higher in PCOS group than control group (0.52 ± 0.058 vs. 0.45 ± 0.059 mm,
P
< 0.01). The mean brachial artery FMD was lower in PCOS group (0.068 ± 0.022 vs. 0.055 ± 0.029,
P
= 0.017).
Conclusions
We found high osteoprotogerin concentrations, increased CIMT and decreased FMD, in women with PCOS. However, there was no correlation between osteoprotegerin and cardiovascular risk markers.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-014-3499-7</identifier><identifier>PMID: 25280574</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Body Mass Index ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiopathology ; Cardiovascular Diseases - physiopathology ; Carotid Intima-Media Thickness ; Case-Control Studies ; Comparative analysis ; Cross-Sectional Studies ; Endocrinology ; Endothelium, Vascular - diagnostic imaging ; Endothelium, Vascular - physiopathology ; Female ; General Gynecology ; Gynecology ; Human Genetics ; Humans ; Lipids - blood ; Medicine ; Medicine & Public Health ; Obesity - physiopathology ; Obstetrics/Perinatology/Midwifery ; Osteoprotegerin - blood ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - diagnostic imaging ; Polycystic Ovary Syndrome - physiopathology ; Risk Factors ; Vasodilation - physiology ; Veins & arteries</subject><ispartof>Archives of gynecology and obstetrics, 2015-05, Vol.291 (5), p.1075-1080</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2014). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-dc1f36fa6068c753e15f698053b8ddc941b89beb3f0e86c2e1f48a432c227cf83</citedby><cites>FETCH-LOGICAL-c475t-dc1f36fa6068c753e15f698053b8ddc941b89beb3f0e86c2e1f48a432c227cf83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-014-3499-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-014-3499-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25280574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abali, Remzi</creatorcontrib><creatorcontrib>Tasdemir, Nicel</creatorcontrib><creatorcontrib>Alpsoy, Seref</creatorcontrib><creatorcontrib>Tasdemir, Ufuk Göker</creatorcontrib><creatorcontrib>Guzel, Savas</creatorcontrib><creatorcontrib>Yuksel, Mehmet Aytac</creatorcontrib><creatorcontrib>Temel Yuksel, Ilkbal</creatorcontrib><creatorcontrib>Yilmaz, Murat</creatorcontrib><title>No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS).
Methods
Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups.
Results
The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 ± 2.29 vs. 10.22 ± 2.25 pmol/L,
P
= 0.026). The mean CIMT was higher in PCOS group than control group (0.52 ± 0.058 vs. 0.45 ± 0.059 mm,
P
< 0.01). The mean brachial artery FMD was lower in PCOS group (0.068 ± 0.022 vs. 0.055 ± 0.029,
P
= 0.017).
Conclusions
We found high osteoprotogerin concentrations, increased CIMT and decreased FMD, in women with PCOS. However, there was no correlation between osteoprotegerin and cardiovascular risk markers.</description><subject>Adult</subject><subject>Body Mass Index</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - physiopathology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Case-Control Studies</subject><subject>Comparative analysis</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinology</subject><subject>Endothelium, Vascular - diagnostic imaging</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>General Gynecology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity - physiopathology</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Osteoprotegerin - blood</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - diagnostic imaging</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><subject>Risk Factors</subject><subject>Vasodilation - physiology</subject><subject>Veins & arteries</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1u1TAQhS1ERS-FB2CDLLFhEzr-ie0sUVV-pIpuYG0lzoSbKte-2A5XeQseGYcUkJBQVx5pvnOsM4eQFwzeMAB9mQAkyAqYrIRsmko_IjsmBa9AM_aY7KBZZ1D6nDxN6Q6AcWPUE3LOa26g1nJHfnwKNOLU5jH4tB-PtMN8QvQ0pIzhGEPGrxhHT13wDn2OG0lb31P0fch7nMZ2ov2Shtm7dUkL7YOvQocJ6SkcittpzPtfmnUIc6bHMC1uSXl0NHxv40LT4vtY2GfkbGinhM_v3wvy5d3156sP1c3t-49Xb28qJ3Wdq96xQaihVaCM07VAVg-qKaFEZ_reNZJ1pumwEwOgUY4jG6Rpy20c59oNRlyQ15tvyfhtxpTtYUwOp6n1GOZkmWm0MJI38mFUKam1UmJFX_2D3oU5-hLEcq5YLUADKxTbKBdDShEHe4zjoVzBMrBrs3Zr1pZm7dqs1UXz8t557g7Y_1H8rrIAfANSWflS2t-v_-_6E_6Qsc4</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Abali, Remzi</creator><creator>Tasdemir, Nicel</creator><creator>Alpsoy, Seref</creator><creator>Tasdemir, Ufuk Göker</creator><creator>Guzel, Savas</creator><creator>Yuksel, Mehmet Aytac</creator><creator>Temel Yuksel, Ilkbal</creator><creator>Yilmaz, Murat</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20150501</creationdate><title>No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome</title><author>Abali, Remzi ; Tasdemir, Nicel ; Alpsoy, Seref ; Tasdemir, Ufuk Göker ; Guzel, Savas ; Yuksel, Mehmet Aytac ; Temel Yuksel, Ilkbal ; Yilmaz, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-dc1f36fa6068c753e15f698053b8ddc941b89beb3f0e86c2e1f48a432c227cf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Body Mass Index</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - physiopathology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Case-Control Studies</topic><topic>Comparative analysis</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinology</topic><topic>Endothelium, Vascular - diagnostic imaging</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>General Gynecology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity - physiopathology</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Osteoprotegerin - blood</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - diagnostic imaging</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Risk Factors</topic><topic>Vasodilation - physiology</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abali, Remzi</creatorcontrib><creatorcontrib>Tasdemir, Nicel</creatorcontrib><creatorcontrib>Alpsoy, Seref</creatorcontrib><creatorcontrib>Tasdemir, Ufuk Göker</creatorcontrib><creatorcontrib>Guzel, Savas</creatorcontrib><creatorcontrib>Yuksel, Mehmet Aytac</creatorcontrib><creatorcontrib>Temel Yuksel, Ilkbal</creatorcontrib><creatorcontrib>Yilmaz, Murat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abali, Remzi</au><au>Tasdemir, Nicel</au><au>Alpsoy, Seref</au><au>Tasdemir, Ufuk Göker</au><au>Guzel, Savas</au><au>Yuksel, Mehmet Aytac</au><au>Temel Yuksel, Ilkbal</au><au>Yilmaz, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>291</volume><issue>5</issue><spage>1075</spage><epage>1080</epage><pages>1075-1080</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS).
Methods
Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups.
Results
The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 ± 2.29 vs. 10.22 ± 2.25 pmol/L,
P
= 0.026). The mean CIMT was higher in PCOS group than control group (0.52 ± 0.058 vs. 0.45 ± 0.059 mm,
P
< 0.01). The mean brachial artery FMD was lower in PCOS group (0.068 ± 0.022 vs. 0.055 ± 0.029,
P
= 0.017).
Conclusions
We found high osteoprotogerin concentrations, increased CIMT and decreased FMD, in women with PCOS. However, there was no correlation between osteoprotegerin and cardiovascular risk markers.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25280574</pmid><doi>10.1007/s00404-014-3499-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2015-05, Vol.291 (5), p.1075-1080 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1897384294 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Body Mass Index Brachial Artery - diagnostic imaging Brachial Artery - physiopathology Cardiovascular Diseases - physiopathology Carotid Intima-Media Thickness Case-Control Studies Comparative analysis Cross-Sectional Studies Endocrinology Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - physiopathology Female General Gynecology Gynecology Human Genetics Humans Lipids - blood Medicine Medicine & Public Health Obesity - physiopathology Obstetrics/Perinatology/Midwifery Osteoprotegerin - blood Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - diagnostic imaging Polycystic Ovary Syndrome - physiopathology Risk Factors Vasodilation - physiology Veins & arteries |
| title | No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome |
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