Mycobacteria Encode Active and Inactive Classes of TesB Fatty-Acyl CoA Thioesterases Revealed through Structural and Functional Analysis

Mycobacteria contain a large number of highly divergent species and exhibit unusual lipid metabolism profiles, believed to play important roles in immune invasion. Thioesterases modulate lipid metabolism through the hydrolysis of activated fatty-acyl CoAs; multiple copies are present in mycobacteria...

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Veröffentlicht in:	Biochemistry (Easton) 2017-03, Vol.56 (10), p.1460-1472
Hauptverfasser:	Swarbrick, Crystall M. D, Bythrow, Glennon V, Aragao, David, Germain, Gabrielle A, Quadri, Luis E. N, Forwood, Jade K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - chemistry Acyl Coenzyme A - metabolism Alanine - chemistry Alanine - metabolism Amino Acid Sequence Amino Acid Substitution Aspartic Acid - chemistry Aspartic Acid - metabolism Bacterial Proteins - chemistry Bacterial Proteins - classification Bacterial Proteins - genetics Bacterial Proteins - metabolism Catalytic Domain Escherichia coli - enzymology Escherichia coli - genetics Gene Expression Genetic Association Studies Hydrolysis Isoenzymes - chemistry Isoenzymes - classification Isoenzymes - genetics Isoenzymes - metabolism Kinetics Mutation Mycobacterium avium Mycobacterium avium - enzymology Mycobacterium avium - genetics Mycobacterium smegmatis Mycobacterium smegmatis - enzymology Mycobacterium smegmatis - genetics Palmitoyl-CoA Hydrolase - chemistry Palmitoyl-CoA Hydrolase - classification Palmitoyl-CoA Hydrolase - genetics Palmitoyl-CoA Hydrolase - metabolism Protein Domains Protein Structure, Quaternary Protein Structure, Secondary Recombinant Proteins - chemistry Recombinant Proteins - classification Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Structure-Activity Relationship
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