Effects of social isolation, re‐socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice
Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress‐associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, th...
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| Veröffentlicht in: | Animal science journal 2017-05, Vol.88 (5), p.798-806 |
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| creator | An, Dong Chen, Wei Yu, De‐Qin Wang, Shi‐Wei Yu, Wei‐Zhi Xu, Hong Wang, Dong‐Mei Zhao, Dan Sun, Yi‐Ping Wu, Jun‐Cheng Tang, Yi‐Yuan Yin, Sheng‐Ming |
| description | Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress‐associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age‐matched controls were evaluated using object recognition, object location and resident‐intruder tests. The recovery of behavioral deficits by re‐socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re‐socialization could completely recover spatial/non‐spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non‐spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions. |
| doi_str_mv | 10.1111/asj.12688 |
| format | Article |
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However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age‐matched controls were evaluated using object recognition, object location and resident‐intruder tests. The recovery of behavioral deficits by re‐socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re‐socialization could completely recover spatial/non‐spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non‐spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions.</description><identifier>ISSN: 1344-3941</identifier><identifier>EISSN: 1740-0929</identifier><identifier>DOI: 10.1111/asj.12688</identifier><identifier>PMID: 27619417</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Age ; Aggression ; Aggressive behavior ; Aggressiveness ; Aging - psychology ; Animal models ; Animals ; BALB/c mice ; behavior ; Cognition ; Disease Models, Animal ; kunming mice ; Male ; Memory tasks ; Mental disorders ; Mental Disorders - psychology ; Mice ; Mice, Inbred BALB C ; Object recognition ; Pattern recognition ; Rodents ; Social behavior ; Social interactions ; Social isolation ; Social Isolation - psychology ; Socialization ; Spatial analysis ; Spatial memory ; Time Factors</subject><ispartof>Animal science journal, 2017-05, Vol.88 (5), p.798-806</ispartof><rights>2016 Japanese Society of Animal Science</rights><rights>2016 Japanese Society of Animal Science.</rights><rights>Copyright © 2017 Japanese Society of Animal Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5048-4e6a1bd6ea6fdd569ff0027afb5ed546d0053d37882f5726640098d8e434f0c23</citedby><cites>FETCH-LOGICAL-c5048-4e6a1bd6ea6fdd569ff0027afb5ed546d0053d37882f5726640098d8e434f0c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fasj.12688$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fasj.12688$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27619417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Dong</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Yu, De‐Qin</creatorcontrib><creatorcontrib>Wang, Shi‐Wei</creatorcontrib><creatorcontrib>Yu, Wei‐Zhi</creatorcontrib><creatorcontrib>Xu, Hong</creatorcontrib><creatorcontrib>Wang, Dong‐Mei</creatorcontrib><creatorcontrib>Zhao, Dan</creatorcontrib><creatorcontrib>Sun, Yi‐Ping</creatorcontrib><creatorcontrib>Wu, Jun‐Cheng</creatorcontrib><creatorcontrib>Tang, Yi‐Yuan</creatorcontrib><creatorcontrib>Yin, Sheng‐Ming</creatorcontrib><title>Effects of social isolation, re‐socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice</title><title>Animal science journal</title><addtitle>Anim Sci J</addtitle><description>Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress‐associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age‐matched controls were evaluated using object recognition, object location and resident‐intruder tests. The recovery of behavioral deficits by re‐socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re‐socialization could completely recover spatial/non‐spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non‐spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions.</description><subject>Age</subject><subject>Aggression</subject><subject>Aggressive behavior</subject><subject>Aggressiveness</subject><subject>Aging - psychology</subject><subject>Animal models</subject><subject>Animals</subject><subject>BALB/c mice</subject><subject>behavior</subject><subject>Cognition</subject><subject>Disease Models, Animal</subject><subject>kunming mice</subject><subject>Male</subject><subject>Memory tasks</subject><subject>Mental disorders</subject><subject>Mental Disorders - psychology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Object recognition</subject><subject>Pattern recognition</subject><subject>Rodents</subject><subject>Social behavior</subject><subject>Social interactions</subject><subject>Social isolation</subject><subject>Social Isolation - psychology</subject><subject>Socialization</subject><subject>Spatial analysis</subject><subject>Spatial memory</subject><subject>Time Factors</subject><issn>1344-3941</issn><issn>1740-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuKFDEUhoMozkUXvoAUuFGwpk-ulVr2DOO1wYW6Dulc2jRVlTHpGhlhwEfwGX0S01WtC0Exm5zz8_GF8CP0CMMZLmeh8_YMEyHlHXSMGwY1tKS9W2bKWE1bho_QSc5bANy0wO-jI9IIXOLmGN1eeu_MLlfRVzmaoLsq5NjpXYjD8yq5H9--z3H4OmWVHmylN64qo4mbIezCtTuEm-Ry3q9r90lfh5gm69tx6MOwqfpgZvB8uTpfmGl_gO553WX38HCfoo8vLj9cvKpX716-vliuasOByZo5ofHaCqeFt5aL1nsA0mi_5s5yJiwAp5Y2UhLPGyIEA2illY5R5sEQeoqezt6rFD-PLu9UH7JxXacHF8essGwbKonEzX-gfGJhb33yB7qNYxrKRxQFSYFzSvi_qPJsqUhSAYV6NlMmxZyT8-oqhV6nG4VB7UtWpWQ1lVzYxwfjuO6d_U3-arUAixn4Ejp383eTWr5_Myt_Ajxir4c</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>An, Dong</creator><creator>Chen, Wei</creator><creator>Yu, De‐Qin</creator><creator>Wang, Shi‐Wei</creator><creator>Yu, Wei‐Zhi</creator><creator>Xu, Hong</creator><creator>Wang, Dong‐Mei</creator><creator>Zhao, Dan</creator><creator>Sun, Yi‐Ping</creator><creator>Wu, Jun‐Cheng</creator><creator>Tang, Yi‐Yuan</creator><creator>Yin, Sheng‐Ming</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Effects of social isolation, re‐socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice</title><author>An, Dong ; Chen, Wei ; Yu, De‐Qin ; Wang, Shi‐Wei ; Yu, Wei‐Zhi ; Xu, Hong ; Wang, Dong‐Mei ; Zhao, Dan ; Sun, Yi‐Ping ; Wu, Jun‐Cheng ; Tang, Yi‐Yuan ; Yin, Sheng‐Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5048-4e6a1bd6ea6fdd569ff0027afb5ed546d0053d37882f5726640098d8e434f0c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aggression</topic><topic>Aggressive behavior</topic><topic>Aggressiveness</topic><topic>Aging - psychology</topic><topic>Animal models</topic><topic>Animals</topic><topic>BALB/c mice</topic><topic>behavior</topic><topic>Cognition</topic><topic>Disease Models, Animal</topic><topic>kunming mice</topic><topic>Male</topic><topic>Memory tasks</topic><topic>Mental disorders</topic><topic>Mental Disorders - psychology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Object recognition</topic><topic>Pattern recognition</topic><topic>Rodents</topic><topic>Social behavior</topic><topic>Social interactions</topic><topic>Social isolation</topic><topic>Social Isolation - psychology</topic><topic>Socialization</topic><topic>Spatial analysis</topic><topic>Spatial memory</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>An, Dong</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Yu, De‐Qin</creatorcontrib><creatorcontrib>Wang, Shi‐Wei</creatorcontrib><creatorcontrib>Yu, Wei‐Zhi</creatorcontrib><creatorcontrib>Xu, Hong</creatorcontrib><creatorcontrib>Wang, Dong‐Mei</creatorcontrib><creatorcontrib>Zhao, Dan</creatorcontrib><creatorcontrib>Sun, Yi‐Ping</creatorcontrib><creatorcontrib>Wu, Jun‐Cheng</creatorcontrib><creatorcontrib>Tang, Yi‐Yuan</creatorcontrib><creatorcontrib>Yin, Sheng‐Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Animal science journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>An, Dong</au><au>Chen, Wei</au><au>Yu, De‐Qin</au><au>Wang, Shi‐Wei</au><au>Yu, Wei‐Zhi</au><au>Xu, Hong</au><au>Wang, Dong‐Mei</au><au>Zhao, Dan</au><au>Sun, Yi‐Ping</au><au>Wu, Jun‐Cheng</au><au>Tang, Yi‐Yuan</au><au>Yin, Sheng‐Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of social isolation, re‐socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice</atitle><jtitle>Animal science journal</jtitle><addtitle>Anim Sci J</addtitle><date>2017-05</date><risdate>2017</risdate><volume>88</volume><issue>5</issue><spage>798</spage><epage>806</epage><pages>798-806</pages><issn>1344-3941</issn><eissn>1740-0929</eissn><abstract>Both Kunming (KM) mice and BALB/c mice have been widely used as rodent models to investigate stress‐associated mental diseases. However, little is known about the different behaviors of KM mice and BALB/c mice after social isolation, particularly cognitive and aggressive behaviors. In this study, the behaviors of KM and BALB/c mice isolated for 2, 4 and 8 weeks and age‐matched controls were evaluated using object recognition, object location and resident‐intruder tests. The recovery of behavioral deficits by re‐socialization was also examined for the isolated mice in adolescence. Our study showed that isolation for 2, 4 and 8 weeks led to cognitive deficits and increased aggressiveness for both KM and BALB/c mice. An important finding is that re‐socialization could completely recover spatial/non‐spatial cognitive deficits resulted from social isolation for both KM and BALB/c mice. In addition, age only impacted aggressiveness of KM mice. Moreover, isolation duration showed different impacts on cognitive and aggressive behaviors for both KM and BALB/c mice. Furthermore, BALB/c mice showed weak spatial/non‐spatial memory and low aggressiveness when they were at the same age and isolation duration, compared to KM mice. In conclusion, KM mice and BALB/c mice behaved characteristically under physiology and isolation conditions.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>27619417</pmid><doi>10.1111/asj.12688</doi><tpages>1</tpages></addata></record> |
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| ispartof | Animal science journal, 2017-05, Vol.88 (5), p.798-806 |
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| subjects | Age Aggression Aggressive behavior Aggressiveness Aging - psychology Animal models Animals BALB/c mice behavior Cognition Disease Models, Animal kunming mice Male Memory tasks Mental disorders Mental Disorders - psychology Mice Mice, Inbred BALB C Object recognition Pattern recognition Rodents Social behavior Social interactions Social isolation Social Isolation - psychology Socialization Spatial analysis Spatial memory Time Factors |
| title | Effects of social isolation, re‐socialization and age on cognitive and aggressive behaviors of Kunming mice and BALB/c mice |
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