Ethanol Extract of Pinus koraiensis Leaf Ameliorates Alcoholic Fatty Liver via the Activation of LKB1–AMPK Signaling In Vitro and In Vivo

Although Pinus koraiensis leaf (PKL) was reported for its anti‐diabetes, anti‐obesity and anticancer effects as a folk remedy, the inhibitory effect of PKL on alcoholic fatty liver has never been elucidated yet. This study investigated the molecular mechanisms of PKL on alcoholic fatty liver in HepG...

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Veröffentlicht in:	Phytotherapy research 2017-05, Vol.31 (5), p.783-791
Hauptverfasser:	Hong, Sang‐Hyuk, Lee, Hyemin, Lee, Hyo‐Jung, Kim, Bonglee, Nam, Min‐Ho, Shim, Bum‐Sang, Kim, Sung‐Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alcohol Alcohol dehydrogenase Alcoholic beverages alcoholic fatty liver Aldehyde dehydrogenase AMP AMP-activated protein kinase AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Anticancer properties Antioxidants Aspartate aminotransferase Biosynthesis Cholesterol Dehydrogenase Dehydrogenases Diabetes mellitus Enzymes Ethanol Ethanol - chemistry Ethanol - toxicity Fatty acids Fatty liver Fatty Liver, Alcoholic Fatty-acid synthase Glutathione Glutathione peroxidase Glutathione transferase Glutathione Transferase - metabolism Hep G2 Cells Hepatocytes Histochemical analysis Humans In vitro methods and tests Kinases Leaves Lipid Metabolism - drug effects Lipogenesis Lipogenesis - drug effects Lipoproteins, LDL - metabolism Liver Liver - drug effects LKB1 protein Male Mice Molecular modelling Oxidation Peroxidase Phosphorylation Pine trees Pinus - chemistry Pinus koraiensis Pinus koraiensis leaf Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Rats Rats, Sprague-Dawley Receptor density Rodents Signal Transduction - drug effects Sterol Regulatory Element Binding Protein 1 - metabolism Superoxide dismutase Synthesis Triglycerides - metabolism
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