Effects of obesity/fatty acids on the expression of GPR120
SCOPE: The effects that fatty acids (FAs) exert on G protein‐coupled receptor‐120 (GPR120) levels, a receptor for FAs, are still unknown. We analyzed the association between GPR120 and obesity, and the FA effects on its expression. METHODS AND RESULTS: GPR120 levels were analyzed in visceral adipose...
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| Veröffentlicht in: | Molecular nutrition & food research 2014-09, Vol.58 (9), p.1852-1860 |
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| creator | Rodriguez‐Pacheco, Francisca Garcia‐Serrano, Sara Garcia‐Escobar, Eva Gutierrez‐Repiso, Carolina Garcia‐Arnes, Juan Valdes, Sergio Gonzalo, Montserrat Soriguer, Federico Moreno‐Ruiz, Francisco J Rodriguez‐Cañete, Alberto Gallego‐Perales, Jose L Martinez‐Ferriz, Abelardo Rojo‐Martínez, Gemma Garcia‐Fuentes, Eduardo |
| description | SCOPE: The effects that fatty acids (FAs) exert on G protein‐coupled receptor‐120 (GPR120) levels, a receptor for FAs, are still unknown. We analyzed the association between GPR120 and obesity, and the FA effects on its expression. METHODS AND RESULTS: GPR120 levels were analyzed in visceral adipose tissue (VAT) from nonobese and morbidly obese subject. VAT GPR120 mRNA and protein levels were lower in morbidly obese subjects (p = 0.004). After, these subjects underwent a high‐fat meal. GPR120 mRNA expression in peripheral blood mononuclear cells in the fasting state was lower in morbidly obese subjects (p = 0.04), with a decrease 3 h after a high‐fat meal only in morbidly obese subjects (p = 0.043). Also, incubations of visceral adipocytes from these subjects were made with different FAs. In nonobese subjects, palmitic, oleic, linoleic, and docosahexaenoic acids produced an increase in GPR120 mRNA and protein levels (p < 0.05). In morbidly obese subjects, only linoleic acid produced an increase in GPR120 mRNA and protein levels (p < 0.05). CONCLUSION: Morbidly obese subjects had lower GPR120 mRNA and protein levels in VAT and a lower mRNA expression after a high‐fat meal in peripheral blood mononuclear cells. The FAs effect on GPR120 mRNA and protein levels in visceral adipocytes was lower in morbidly obese subjects. |
| doi_str_mv | 10.1002/mnfr.201300666 |
| format | Article |
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We analyzed the association between GPR120 and obesity, and the FA effects on its expression. METHODS AND RESULTS: GPR120 levels were analyzed in visceral adipose tissue (VAT) from nonobese and morbidly obese subject. VAT GPR120 mRNA and protein levels were lower in morbidly obese subjects (p = 0.004). After, these subjects underwent a high‐fat meal. GPR120 mRNA expression in peripheral blood mononuclear cells in the fasting state was lower in morbidly obese subjects (p = 0.04), with a decrease 3 h after a high‐fat meal only in morbidly obese subjects (p = 0.043). Also, incubations of visceral adipocytes from these subjects were made with different FAs. In nonobese subjects, palmitic, oleic, linoleic, and docosahexaenoic acids produced an increase in GPR120 mRNA and protein levels (p < 0.05). In morbidly obese subjects, only linoleic acid produced an increase in GPR120 mRNA and protein levels (p < 0.05). CONCLUSION: Morbidly obese subjects had lower GPR120 mRNA and protein levels in VAT and a lower mRNA expression after a high‐fat meal in peripheral blood mononuclear cells. The FAs effect on GPR120 mRNA and protein levels in visceral adipocytes was lower in morbidly obese subjects.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201300666</identifier><identifier>PMID: 24913719</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH</publisher><subject>Adipocyte ; adipocytes ; Adipocytes - metabolism ; Adipose tissue ; Adult ; Biological and medical sciences ; Case-Control Studies ; Diet, High-Fat - adverse effects ; docosahexaenoic acid ; fasting ; Fatty acids ; Fatty Acids - metabolism ; Fatty Acids - pharmacology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; gene expression ; Gene Expression Regulation ; GPR120 ; High-fat meal ; Humans ; Intra-Abdominal Fat - metabolism ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; linoleic acid ; Male ; Medical sciences ; messenger RNA ; Metabolic diseases ; Middle Aged ; mononuclear leukocytes ; Obesity ; Obesity, Morbid - genetics ; Obesity, Morbid - metabolism ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Reference Values ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Molecular nutrition & food research, 2014-09, Vol.58 (9), p.1852-1860</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 INIST-CNRS</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5311-58175732207d51ebe2273341201e04908d5fd821de5db0cc928fa6c84681cb1a3</citedby><cites>FETCH-LOGICAL-c5311-58175732207d51ebe2273341201e04908d5fd821de5db0cc928fa6c84681cb1a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201300666$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201300666$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28789459$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24913719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez‐Pacheco, Francisca</creatorcontrib><creatorcontrib>Garcia‐Serrano, Sara</creatorcontrib><creatorcontrib>Garcia‐Escobar, Eva</creatorcontrib><creatorcontrib>Gutierrez‐Repiso, Carolina</creatorcontrib><creatorcontrib>Garcia‐Arnes, Juan</creatorcontrib><creatorcontrib>Valdes, Sergio</creatorcontrib><creatorcontrib>Gonzalo, Montserrat</creatorcontrib><creatorcontrib>Soriguer, Federico</creatorcontrib><creatorcontrib>Moreno‐Ruiz, Francisco J</creatorcontrib><creatorcontrib>Rodriguez‐Cañete, Alberto</creatorcontrib><creatorcontrib>Gallego‐Perales, Jose L</creatorcontrib><creatorcontrib>Martinez‐Ferriz, Abelardo</creatorcontrib><creatorcontrib>Rojo‐Martínez, Gemma</creatorcontrib><creatorcontrib>Garcia‐Fuentes, Eduardo</creatorcontrib><title>Effects of obesity/fatty acids on the expression of GPR120</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>SCOPE: The effects that fatty acids (FAs) exert on G protein‐coupled receptor‐120 (GPR120) levels, a receptor for FAs, are still unknown. We analyzed the association between GPR120 and obesity, and the FA effects on its expression. METHODS AND RESULTS: GPR120 levels were analyzed in visceral adipose tissue (VAT) from nonobese and morbidly obese subject. VAT GPR120 mRNA and protein levels were lower in morbidly obese subjects (p = 0.004). After, these subjects underwent a high‐fat meal. GPR120 mRNA expression in peripheral blood mononuclear cells in the fasting state was lower in morbidly obese subjects (p = 0.04), with a decrease 3 h after a high‐fat meal only in morbidly obese subjects (p = 0.043). Also, incubations of visceral adipocytes from these subjects were made with different FAs. In nonobese subjects, palmitic, oleic, linoleic, and docosahexaenoic acids produced an increase in GPR120 mRNA and protein levels (p < 0.05). In morbidly obese subjects, only linoleic acid produced an increase in GPR120 mRNA and protein levels (p < 0.05). CONCLUSION: Morbidly obese subjects had lower GPR120 mRNA and protein levels in VAT and a lower mRNA expression after a high‐fat meal in peripheral blood mononuclear cells. The FAs effect on GPR120 mRNA and protein levels in visceral adipocytes was lower in morbidly obese subjects.</description><subject>Adipocyte</subject><subject>adipocytes</subject><subject>Adipocytes - metabolism</subject><subject>Adipose tissue</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Diet, High-Fat - adverse effects</subject><subject>docosahexaenoic acid</subject><subject>fasting</subject><subject>Fatty acids</subject><subject>Fatty Acids - metabolism</subject><subject>Fatty Acids - pharmacology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gene expression</subject><subject>Gene Expression Regulation</subject><subject>GPR120</subject><subject>High-fat meal</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>linoleic acid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>messenger RNA</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>mononuclear leukocytes</subject><subject>Obesity</subject><subject>Obesity, Morbid - genetics</subject><subject>Obesity, Morbid - metabolism</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Reference Values</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9P2zAUB3Br2gSs47oj5DJpl5T37Dh2dkMIuh_AJjY0iYvlOM-QLW06O9Xofz9X6cqRk-Po875--jL2FmGKAPxkvvBhygEFQFmWL9gBlijyAoV4ufvmcp-9jvEXgEBeiD22z4sKhcLqgH04957cELPeZ31NsR3WJ94Owzqzrm3S70U2PFBGj8tAMbbpmuDs2w1yeMNeedtFOtyeE3Z7cf7j7GN--XX26ez0MndSIOZSo5JKcA6qkUg1ca6ESFsBEhQV6Eb6RnNsSDY1OFdx7W3pdFFqdDVaMWHvx9xl6P-sKA5m3kZHXWcX1K-iQV0poXnKep7KElNVUkKi05G60McYyJtlaOc2rA2C2VRrNtWaXbVp4Gibvarn1Oz4_y4TeLcFNjrb-WAXro1PTitdFXLjitH9bTtaP_Osubq-uOE8bT1h-TjWxoEed2M2_DalEkqan9czc4da3X0BZT4nfzx6b3tj70Na5fZ7yi0AUAqhuPgHa3Kl1Q</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Rodriguez‐Pacheco, Francisca</creator><creator>Garcia‐Serrano, Sara</creator><creator>Garcia‐Escobar, Eva</creator><creator>Gutierrez‐Repiso, Carolina</creator><creator>Garcia‐Arnes, Juan</creator><creator>Valdes, Sergio</creator><creator>Gonzalo, Montserrat</creator><creator>Soriguer, Federico</creator><creator>Moreno‐Ruiz, Francisco J</creator><creator>Rodriguez‐Cañete, Alberto</creator><creator>Gallego‐Perales, Jose L</creator><creator>Martinez‐Ferriz, Abelardo</creator><creator>Rojo‐Martínez, Gemma</creator><creator>Garcia‐Fuentes, Eduardo</creator><general>Wiley-VCH</general><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>201409</creationdate><title>Effects of obesity/fatty acids on the expression of GPR120</title><author>Rodriguez‐Pacheco, Francisca ; Garcia‐Serrano, Sara ; Garcia‐Escobar, Eva ; Gutierrez‐Repiso, Carolina ; Garcia‐Arnes, Juan ; Valdes, Sergio ; Gonzalo, Montserrat ; Soriguer, Federico ; Moreno‐Ruiz, Francisco J ; Rodriguez‐Cañete, Alberto ; Gallego‐Perales, Jose L ; Martinez‐Ferriz, Abelardo ; Rojo‐Martínez, Gemma ; Garcia‐Fuentes, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5311-58175732207d51ebe2273341201e04908d5fd821de5db0cc928fa6c84681cb1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipocyte</topic><topic>adipocytes</topic><topic>Adipocytes - metabolism</topic><topic>Adipose tissue</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Diet, High-Fat - adverse effects</topic><topic>docosahexaenoic acid</topic><topic>fasting</topic><topic>Fatty acids</topic><topic>Fatty Acids - metabolism</topic><topic>Fatty Acids - pharmacology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gene expression</topic><topic>Gene Expression Regulation</topic><topic>GPR120</topic><topic>High-fat meal</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - metabolism</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>linoleic acid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>messenger RNA</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>mononuclear leukocytes</topic><topic>Obesity</topic><topic>Obesity, Morbid - genetics</topic><topic>Obesity, Morbid - metabolism</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Reference Values</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez‐Pacheco, Francisca</creatorcontrib><creatorcontrib>Garcia‐Serrano, Sara</creatorcontrib><creatorcontrib>Garcia‐Escobar, Eva</creatorcontrib><creatorcontrib>Gutierrez‐Repiso, Carolina</creatorcontrib><creatorcontrib>Garcia‐Arnes, Juan</creatorcontrib><creatorcontrib>Valdes, Sergio</creatorcontrib><creatorcontrib>Gonzalo, Montserrat</creatorcontrib><creatorcontrib>Soriguer, Federico</creatorcontrib><creatorcontrib>Moreno‐Ruiz, Francisco J</creatorcontrib><creatorcontrib>Rodriguez‐Cañete, Alberto</creatorcontrib><creatorcontrib>Gallego‐Perales, Jose L</creatorcontrib><creatorcontrib>Martinez‐Ferriz, Abelardo</creatorcontrib><creatorcontrib>Rojo‐Martínez, Gemma</creatorcontrib><creatorcontrib>Garcia‐Fuentes, Eduardo</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez‐Pacheco, Francisca</au><au>Garcia‐Serrano, Sara</au><au>Garcia‐Escobar, Eva</au><au>Gutierrez‐Repiso, Carolina</au><au>Garcia‐Arnes, Juan</au><au>Valdes, Sergio</au><au>Gonzalo, Montserrat</au><au>Soriguer, Federico</au><au>Moreno‐Ruiz, Francisco J</au><au>Rodriguez‐Cañete, Alberto</au><au>Gallego‐Perales, Jose L</au><au>Martinez‐Ferriz, Abelardo</au><au>Rojo‐Martínez, Gemma</au><au>Garcia‐Fuentes, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of obesity/fatty acids on the expression of GPR120</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2014-09</date><risdate>2014</risdate><volume>58</volume><issue>9</issue><spage>1852</spage><epage>1860</epage><pages>1852-1860</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>SCOPE: The effects that fatty acids (FAs) exert on G protein‐coupled receptor‐120 (GPR120) levels, a receptor for FAs, are still unknown. We analyzed the association between GPR120 and obesity, and the FA effects on its expression. METHODS AND RESULTS: GPR120 levels were analyzed in visceral adipose tissue (VAT) from nonobese and morbidly obese subject. VAT GPR120 mRNA and protein levels were lower in morbidly obese subjects (p = 0.004). After, these subjects underwent a high‐fat meal. GPR120 mRNA expression in peripheral blood mononuclear cells in the fasting state was lower in morbidly obese subjects (p = 0.04), with a decrease 3 h after a high‐fat meal only in morbidly obese subjects (p = 0.043). Also, incubations of visceral adipocytes from these subjects were made with different FAs. In nonobese subjects, palmitic, oleic, linoleic, and docosahexaenoic acids produced an increase in GPR120 mRNA and protein levels (p < 0.05). In morbidly obese subjects, only linoleic acid produced an increase in GPR120 mRNA and protein levels (p < 0.05). CONCLUSION: Morbidly obese subjects had lower GPR120 mRNA and protein levels in VAT and a lower mRNA expression after a high‐fat meal in peripheral blood mononuclear cells. The FAs effect on GPR120 mRNA and protein levels in visceral adipocytes was lower in morbidly obese subjects.</abstract><cop>Weinheim</cop><pub>Wiley-VCH</pub><pmid>24913719</pmid><doi>10.1002/mnfr.201300666</doi><tpages>9</tpages></addata></record> |
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| ispartof | Molecular nutrition & food research, 2014-09, Vol.58 (9), p.1852-1860 |
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| subjects | Adipocyte adipocytes Adipocytes - metabolism Adipose tissue Adult Biological and medical sciences Case-Control Studies Diet, High-Fat - adverse effects docosahexaenoic acid fasting Fatty acids Fatty Acids - metabolism Fatty Acids - pharmacology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation GPR120 High-fat meal Humans Intra-Abdominal Fat - metabolism Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism linoleic acid Male Medical sciences messenger RNA Metabolic diseases Middle Aged mononuclear leukocytes Obesity Obesity, Morbid - genetics Obesity, Morbid - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Reference Values Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of obesity/fatty acids on the expression of GPR120 |
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