Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging‐Induced Renal Inflammation and Senescence via NADPH Oxidase‐Mediated Reactive Oxygen Generation
The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways related to age‐related oxidative stress in aged rats. Magnesium lithospermate B was orally administered at a dose of 2‐ or 8‐mg/kg body weight...
Gespeichert in:
Veröffentlicht in: | Phytotherapy research 2017-05, Vol.31 (5), p.721-728 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 728 |
---|---|
container_issue | 5 |
container_start_page | 721 |
container_title | Phytotherapy research |
container_volume | 31 |
creator | Park, Chan Hum Shin, Sung Ho Lee, Eun Kyeong Kim, Dae Hyun Kim, Min‐Jo Roh, Seong‐Soo Yokozawa, Takako Chung, Hae Young |
description | The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways related to age‐related oxidative stress in aged rats. Magnesium lithospermate B was orally administered at a dose of 2‐ or 8‐mg/kg body weight for 16 consecutive days, and the effects were compared with those of vehicle in old and young rats. Magnesium lithospermate B administration to old rats ameliorated renal oxidative stress through reduction of reactive oxygen species. The old rats exhibited a dysregulation of the expression of proteins related to oxidative stress and inflammation in the kidneys, and MLB administration significantly reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho‐p38, nuclear factor‐kappa B p65, cyclooxygenase‐2, and inducible nitric oxide synthase. In addition, MLB‐treated old rats showed lower levels of senescence‐related proteins such as p16, ADP‐ribosylation factor 6, p53, and p21 through effects on the mitogen‐activated protein kinase pathway. Magnesium lithospermate B administration also significantly attenuated the age‐related increase in serum urea nitrogen, reflecting renal dysfunction, up‐regulated podocyte structural proteins, and reduced renal structural injury. Our results provide important evidence that MLB reduces the renal damage of oxidative stress in old rats. Copyright © 2017 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/ptr.5789 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1897381529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1869968238</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3389-da89b0431450a9dc34653f945f39fc138c1e06b33e54d3b5ebd35889de182d753</originalsourceid><addsrcrecordid>eNqNkstu1TAQhi1ERU8LEk-ALLFhk-JLnNjL00LbI51e1BaJXeTEk9RV4qR2UjiseASehIfiSXB6YcEC4c1Inu__Z2T_CL2mZI8Swt4Po98TuVTP0IISpRIqcv4cLYgSNEmp_LyNdkK4IYQoRtIXaJtJRuNJF-jniW4cBDt1eG3H6z4M4Ds9At7Hte87fKnbO6txZ9vR9t5f228a70-uAbzsoI1XkQ142VjX_Pr-Y-XMVIHBF-B0i1eubnUX3WzvsHYGX0IcVYGrAM-mp8sP58f47Ks1OkBUn4Cx0W6W62q0dxB7mwYcPoo6f2_zEm3Vug3w6rHuok-HH68OjpP12dHqYLlOBs6lSoyWqiQpp6kgWpmKp5ngtUpFzVVdUS4rCiQrOQeRGl4KKA0XUioDVDKTC76L3j34Dr6_nSCMRWfj5m2rHfRTKKhUOZdUMPUfaKZUJhmXEX37F3rTTz4-VaQUz4iQKWH_pKSiGWUsn6k3j9RUdmCKwdtO-03x9LURSB6AL7aFzZ8-JcUcmSJGppgjU5xfXcyV_waxlbVX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1891612272</pqid></control><display><type>article</type><title>Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging‐Induced Renal Inflammation and Senescence via NADPH Oxidase‐Mediated Reactive Oxygen Generation</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Park, Chan Hum ; Shin, Sung Ho ; Lee, Eun Kyeong ; Kim, Dae Hyun ; Kim, Min‐Jo ; Roh, Seong‐Soo ; Yokozawa, Takako ; Chung, Hae Young</creator><creatorcontrib>Park, Chan Hum ; Shin, Sung Ho ; Lee, Eun Kyeong ; Kim, Dae Hyun ; Kim, Min‐Jo ; Roh, Seong‐Soo ; Yokozawa, Takako ; Chung, Hae Young</creatorcontrib><description>The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways related to age‐related oxidative stress in aged rats. Magnesium lithospermate B was orally administered at a dose of 2‐ or 8‐mg/kg body weight for 16 consecutive days, and the effects were compared with those of vehicle in old and young rats. Magnesium lithospermate B administration to old rats ameliorated renal oxidative stress through reduction of reactive oxygen species. The old rats exhibited a dysregulation of the expression of proteins related to oxidative stress and inflammation in the kidneys, and MLB administration significantly reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho‐p38, nuclear factor‐kappa B p65, cyclooxygenase‐2, and inducible nitric oxide synthase. In addition, MLB‐treated old rats showed lower levels of senescence‐related proteins such as p16, ADP‐ribosylation factor 6, p53, and p21 through effects on the mitogen‐activated protein kinase pathway. Magnesium lithospermate B administration also significantly attenuated the age‐related increase in serum urea nitrogen, reflecting renal dysfunction, up‐regulated podocyte structural proteins, and reduced renal structural injury. Our results provide important evidence that MLB reduces the renal damage of oxidative stress in old rats. Copyright © 2017 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.5789</identifier><identifier>PMID: 28211114</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adenosine diphosphate ; ADP-ribosylation ; ADP-ribosylation factor 6 ; ADP-Ribosylation Factors ; Aging ; Aging (artificial) ; Aging - drug effects ; Aging - physiology ; Animals ; Body weight ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-2 ; Drugs, Chinese Herbal - chemistry ; Drugs, Chinese Herbal - pharmacology ; Fuel consumption ; GTP-binding protein ; inflammation ; Inflammation - metabolism ; Injury prevention ; Kidney Diseases - drug therapy ; Kidneys ; Kinases ; Magnesium ; magnesium lithospermate B ; Male ; MAP kinase ; Mitogen-Activated Protein Kinases - metabolism ; NAD(P)H oxidase ; NADPH Oxidases - metabolism ; NADPH-diaphorase ; NF-kappa B - metabolism ; NF-κB protein ; Nicotinamide ; Nicotinamide adenine dinucleotide ; Nitric oxide ; Nitric-oxide synthase ; NOX4 protein ; Oral administration ; Oxidase ; Oxidative stress ; Oxidative Stress - drug effects ; p53 Protein ; Phosphates ; Protein kinase ; Proteins ; Rats ; Rats, Sprague-Dawley ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; renal damage ; Renal function ; Rodents ; Salvia miltiorrhiza ; Salvia miltiorrhiza - chemistry ; Senescence ; Structural proteins ; Urea</subject><ispartof>Phytotherapy research, 2017-05, Vol.31 (5), p.721-728</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-2423-1973 ; 0000-0002-3215-8828</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.5789$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.5789$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28211114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Chan Hum</creatorcontrib><creatorcontrib>Shin, Sung Ho</creatorcontrib><creatorcontrib>Lee, Eun Kyeong</creatorcontrib><creatorcontrib>Kim, Dae Hyun</creatorcontrib><creatorcontrib>Kim, Min‐Jo</creatorcontrib><creatorcontrib>Roh, Seong‐Soo</creatorcontrib><creatorcontrib>Yokozawa, Takako</creatorcontrib><creatorcontrib>Chung, Hae Young</creatorcontrib><title>Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging‐Induced Renal Inflammation and Senescence via NADPH Oxidase‐Mediated Reactive Oxygen Generation</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways related to age‐related oxidative stress in aged rats. Magnesium lithospermate B was orally administered at a dose of 2‐ or 8‐mg/kg body weight for 16 consecutive days, and the effects were compared with those of vehicle in old and young rats. Magnesium lithospermate B administration to old rats ameliorated renal oxidative stress through reduction of reactive oxygen species. The old rats exhibited a dysregulation of the expression of proteins related to oxidative stress and inflammation in the kidneys, and MLB administration significantly reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho‐p38, nuclear factor‐kappa B p65, cyclooxygenase‐2, and inducible nitric oxide synthase. In addition, MLB‐treated old rats showed lower levels of senescence‐related proteins such as p16, ADP‐ribosylation factor 6, p53, and p21 through effects on the mitogen‐activated protein kinase pathway. Magnesium lithospermate B administration also significantly attenuated the age‐related increase in serum urea nitrogen, reflecting renal dysfunction, up‐regulated podocyte structural proteins, and reduced renal structural injury. Our results provide important evidence that MLB reduces the renal damage of oxidative stress in old rats. Copyright © 2017 John Wiley & Sons, Ltd.</description><subject>Adenosine diphosphate</subject><subject>ADP-ribosylation</subject><subject>ADP-ribosylation factor 6</subject><subject>ADP-Ribosylation Factors</subject><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Body weight</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase-2</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Fuel consumption</subject><subject>GTP-binding protein</subject><subject>inflammation</subject><subject>Inflammation - metabolism</subject><subject>Injury prevention</subject><subject>Kidney Diseases - drug therapy</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Magnesium</subject><subject>magnesium lithospermate B</subject><subject>Male</subject><subject>MAP kinase</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>NAD(P)H oxidase</subject><subject>NADPH Oxidases - metabolism</subject><subject>NADPH-diaphorase</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nicotinamide</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>NOX4 protein</subject><subject>Oral administration</subject><subject>Oxidase</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>p53 Protein</subject><subject>Phosphates</subject><subject>Protein kinase</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>renal damage</subject><subject>Renal function</subject><subject>Rodents</subject><subject>Salvia miltiorrhiza</subject><subject>Salvia miltiorrhiza - chemistry</subject><subject>Senescence</subject><subject>Structural proteins</subject><subject>Urea</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkstu1TAQhi1ERU8LEk-ALLFhk-JLnNjL00LbI51e1BaJXeTEk9RV4qR2UjiseASehIfiSXB6YcEC4c1Inu__Z2T_CL2mZI8Swt4Po98TuVTP0IISpRIqcv4cLYgSNEmp_LyNdkK4IYQoRtIXaJtJRuNJF-jniW4cBDt1eG3H6z4M4Ds9At7Hte87fKnbO6txZ9vR9t5f228a70-uAbzsoI1XkQ142VjX_Pr-Y-XMVIHBF-B0i1eubnUX3WzvsHYGX0IcVYGrAM-mp8sP58f47Ks1OkBUn4Cx0W6W62q0dxB7mwYcPoo6f2_zEm3Vug3w6rHuok-HH68OjpP12dHqYLlOBs6lSoyWqiQpp6kgWpmKp5ngtUpFzVVdUS4rCiQrOQeRGl4KKA0XUioDVDKTC76L3j34Dr6_nSCMRWfj5m2rHfRTKKhUOZdUMPUfaKZUJhmXEX37F3rTTz4-VaQUz4iQKWH_pKSiGWUsn6k3j9RUdmCKwdtO-03x9LURSB6AL7aFzZ8-JcUcmSJGppgjU5xfXcyV_waxlbVX</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Park, Chan Hum</creator><creator>Shin, Sung Ho</creator><creator>Lee, Eun Kyeong</creator><creator>Kim, Dae Hyun</creator><creator>Kim, Min‐Jo</creator><creator>Roh, Seong‐Soo</creator><creator>Yokozawa, Takako</creator><creator>Chung, Hae Young</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2423-1973</orcidid><orcidid>https://orcid.org/0000-0002-3215-8828</orcidid></search><sort><creationdate>201705</creationdate><title>Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging‐Induced Renal Inflammation and Senescence via NADPH Oxidase‐Mediated Reactive Oxygen Generation</title><author>Park, Chan Hum ; Shin, Sung Ho ; Lee, Eun Kyeong ; Kim, Dae Hyun ; Kim, Min‐Jo ; Roh, Seong‐Soo ; Yokozawa, Takako ; Chung, Hae Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3389-da89b0431450a9dc34653f945f39fc138c1e06b33e54d3b5ebd35889de182d753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenosine diphosphate</topic><topic>ADP-ribosylation</topic><topic>ADP-ribosylation factor 6</topic><topic>ADP-Ribosylation Factors</topic><topic>Aging</topic><topic>Aging (artificial)</topic><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Body weight</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-2</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Fuel consumption</topic><topic>GTP-binding protein</topic><topic>inflammation</topic><topic>Inflammation - metabolism</topic><topic>Injury prevention</topic><topic>Kidney Diseases - drug therapy</topic><topic>Kidneys</topic><topic>Kinases</topic><topic>Magnesium</topic><topic>magnesium lithospermate B</topic><topic>Male</topic><topic>MAP kinase</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>NAD(P)H oxidase</topic><topic>NADPH Oxidases - metabolism</topic><topic>NADPH-diaphorase</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>Nicotinamide</topic><topic>Nicotinamide adenine dinucleotide</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>NOX4 protein</topic><topic>Oral administration</topic><topic>Oxidase</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>p53 Protein</topic><topic>Phosphates</topic><topic>Protein kinase</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>renal damage</topic><topic>Renal function</topic><topic>Rodents</topic><topic>Salvia miltiorrhiza</topic><topic>Salvia miltiorrhiza - chemistry</topic><topic>Senescence</topic><topic>Structural proteins</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Chan Hum</creatorcontrib><creatorcontrib>Shin, Sung Ho</creatorcontrib><creatorcontrib>Lee, Eun Kyeong</creatorcontrib><creatorcontrib>Kim, Dae Hyun</creatorcontrib><creatorcontrib>Kim, Min‐Jo</creatorcontrib><creatorcontrib>Roh, Seong‐Soo</creatorcontrib><creatorcontrib>Yokozawa, Takako</creatorcontrib><creatorcontrib>Chung, Hae Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Chan Hum</au><au>Shin, Sung Ho</au><au>Lee, Eun Kyeong</au><au>Kim, Dae Hyun</au><au>Kim, Min‐Jo</au><au>Roh, Seong‐Soo</au><au>Yokozawa, Takako</au><au>Chung, Hae Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging‐Induced Renal Inflammation and Senescence via NADPH Oxidase‐Mediated Reactive Oxygen Generation</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother Res</addtitle><date>2017-05</date><risdate>2017</risdate><volume>31</volume><issue>5</issue><spage>721</spage><epage>728</epage><pages>721-728</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>The present study was conducted to examine whether magnesium lithospermate B (MLB) extracted from Salviae miltiorrhizae radix was renoprotective in pathways related to age‐related oxidative stress in aged rats. Magnesium lithospermate B was orally administered at a dose of 2‐ or 8‐mg/kg body weight for 16 consecutive days, and the effects were compared with those of vehicle in old and young rats. Magnesium lithospermate B administration to old rats ameliorated renal oxidative stress through reduction of reactive oxygen species. The old rats exhibited a dysregulation of the expression of proteins related to oxidative stress and inflammation in the kidneys, and MLB administration significantly reduced the protein expression of major subunits of nicotinamide adenine dinucleotide phosphate oxidase (Nox4 and p22phox), phospho‐p38, nuclear factor‐kappa B p65, cyclooxygenase‐2, and inducible nitric oxide synthase. In addition, MLB‐treated old rats showed lower levels of senescence‐related proteins such as p16, ADP‐ribosylation factor 6, p53, and p21 through effects on the mitogen‐activated protein kinase pathway. Magnesium lithospermate B administration also significantly attenuated the age‐related increase in serum urea nitrogen, reflecting renal dysfunction, up‐regulated podocyte structural proteins, and reduced renal structural injury. Our results provide important evidence that MLB reduces the renal damage of oxidative stress in old rats. Copyright © 2017 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28211114</pmid><doi>10.1002/ptr.5789</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2423-1973</orcidid><orcidid>https://orcid.org/0000-0002-3215-8828</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0951-418X |
ispartof | Phytotherapy research, 2017-05, Vol.31 (5), p.721-728 |
issn | 0951-418X 1099-1573 |
language | eng |
recordid | cdi_proquest_miscellaneous_1897381529 |
source | MEDLINE; Access via Wiley Online Library |
subjects | Adenosine diphosphate ADP-ribosylation ADP-ribosylation factor 6 ADP-Ribosylation Factors Aging Aging (artificial) Aging - drug effects Aging - physiology Animals Body weight Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Fuel consumption GTP-binding protein inflammation Inflammation - metabolism Injury prevention Kidney Diseases - drug therapy Kidneys Kinases Magnesium magnesium lithospermate B Male MAP kinase Mitogen-Activated Protein Kinases - metabolism NAD(P)H oxidase NADPH Oxidases - metabolism NADPH-diaphorase NF-kappa B - metabolism NF-κB protein Nicotinamide Nicotinamide adenine dinucleotide Nitric oxide Nitric-oxide synthase NOX4 protein Oral administration Oxidase Oxidative stress Oxidative Stress - drug effects p53 Protein Phosphates Protein kinase Proteins Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism renal damage Renal function Rodents Salvia miltiorrhiza Salvia miltiorrhiza - chemistry Senescence Structural proteins Urea |
title | Magnesium Lithospermate B from Salvia miltiorrhiza Bunge Ameliorates Aging‐Induced Renal Inflammation and Senescence via NADPH Oxidase‐Mediated Reactive Oxygen Generation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A41%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Magnesium%20Lithospermate%20B%20from%20Salvia%20miltiorrhiza%20Bunge%20Ameliorates%20Aging%E2%80%90Induced%20Renal%20Inflammation%20and%20Senescence%20via%20NADPH%20Oxidase%E2%80%90Mediated%20Reactive%20Oxygen%20Generation&rft.jtitle=Phytotherapy%20research&rft.au=Park,%20Chan%20Hum&rft.date=2017-05&rft.volume=31&rft.issue=5&rft.spage=721&rft.epage=728&rft.pages=721-728&rft.issn=0951-418X&rft.eissn=1099-1573&rft.coden=PHYREH&rft_id=info:doi/10.1002/ptr.5789&rft_dat=%3Cproquest_pubme%3E1869968238%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1891612272&rft_id=info:pmid/28211114&rfr_iscdi=true |