The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine‐expressing myeloma cells

Summary We have discovered that a small cationic molecule, GW4869, is cytotoxic to a subset of myeloma cell lines and primary myeloma plasma cells. Biochemical analysis revealed that GW4869 binds to anionic phospholipids such as phosphatidylserine ‐ a lipid normally confined to the intracellular sid...

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Veröffentlicht in:	British journal of haematology 2017-05, Vol.177 (3), p.423-440
Hauptverfasser:	Vuckovic, Slavica, Vandyke, Kate, Rickards, David A., McCauley Winter, Padraig, Brown, Simon H. J., Mitchell, Todd W., Liu, Jun, Lu, Jun, Askenase, Philip W., Yuriev, Elizabeth, Capuano, Ben, Ramsland, Paul A., Hill, Geoffrey R., Zannettino, Andrew C. W., Hutchinson, Andrew T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - administration & dosage Aniline Compounds - pharmacology Aniline Compounds - therapeutic use Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzylidene Compounds - administration & dosage Benzylidene Compounds - pharmacology Benzylidene Compounds - therapeutic use Biochemical analysis Brefeldin A Cell Death - drug effects Cell Line, Tumor Cell surface Cytotoxicity Dose-Response Relationship, Drug GW4869 Hematology Humans Mice, SCID Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Multiple Myeloma - pathology Myeloma Phosphatidylserine Phosphatidylserines - metabolism Phospholipids Plasma Plasma cells small molecule Tumor cell lines Tumor Cells, Cultured Xenograft Model Antitumor Assays
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