Serum Alanine Aminotransferase Independently Correlates with Intrahepatic Triglyceride Contents in Obese Subjects
Background and Aim Liver enzymes including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) are well recognized as surrogate makers reflecting non-alcoholic fatty liver disease (NAFLD). However, the associations of serum ALT, AST and GGT with...
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| Veröffentlicht in: | Digestive diseases and sciences 2014-10, Vol.59 (10), p.2470-2476 |
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| creator | Chen, Zheng Han, Cheng-Kun Pan, Ling-Ling Zhang, Hui-Jie Ma, Zhi-Min Huang, Zhu-Feng Chen, Shi Zhuang, Xiong-Jie Li, Zhi-Bin Li, Xiao-Ying Li, Xue-Jun Yang, Shu-Yu |
| description | Background and Aim
Liver enzymes including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) are well recognized as surrogate makers reflecting non-alcoholic fatty liver disease (NAFLD). However, the associations of serum ALT, AST and GGT with hepatic lipid contents are not well established. The aim of this study was to investigate the relationship between liver enzymes and intrahepatic triglyceride (IHTG) contents, and explore the feasibility in using liver enzymes to reflect accumulation of IHTG in obese subjects.
Methods
A cross-sectional analysis was conducted in 475 obese adults aged 40–65 years. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose and lipid profiles were measured. The liver triglyceride contents of subjects were determined by
1
H-MRS.
Results
Serum ALT, AST and GGT were positively correlated with IHTG contents (
p
|
| doi_str_mv | 10.1007/s10620-014-3214-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1897380836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712942211</galeid><sourcerecordid>A712942211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-a0a95befff9d15e0cef0c46ac6387f15a84235a8e794d7e589089eaa408129c83</originalsourceid><addsrcrecordid>eNqFkk1r3DAQhkVpabZpf0AvxdBLL071YevjuCz9CARySHoWWnm00WLLG8mm7L_PuJuWtLQUwUhonneYkV5C3jJ6wShVHwujktOasqYWfAnPyIq1StS8lfo5WVEm8cyYPCOvStlTSo1i8iU5442WjAqxIvc3kOehWvcuxQTVeohpnLJLJUB2BarL1MEBMKSpP1abMWfo3QSl-h6nO8wiewcHN0Vf3ea4648ecuwAyTShplQxVddbwEo383YPfiqvyYvg-gJvHvdz8u3zp9vN1_rq-svlZn1V-7bhU-2oM-0WQgimYy1QD4H6RjovhVaBtU43XGAEZZpOQasN1Qaca6hm3HgtzsmHU91DHu9nKJMdYvHQ46QwzsUybZTQVAv5f7SVzChl9IK-_wPdj3NOOMgPSjKumyfUzvVgYwrLm_qlqF0rbK_h-CtIXfyFwtXBEP2YIES8_03ATgKfx1IyBHvIcXD5aBm1iyPsyREWHWEXR1iBmnePDc_bAbpfip8WQICfgIKptIP8ZKJ_Vn0AkSW_rQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1561612846</pqid></control><display><type>article</type><title>Serum Alanine Aminotransferase Independently Correlates with Intrahepatic Triglyceride Contents in Obese Subjects</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Zheng ; Han, Cheng-Kun ; Pan, Ling-Ling ; Zhang, Hui-Jie ; Ma, Zhi-Min ; Huang, Zhu-Feng ; Chen, Shi ; Zhuang, Xiong-Jie ; Li, Zhi-Bin ; Li, Xiao-Ying ; Li, Xue-Jun ; Yang, Shu-Yu</creator><creatorcontrib>Chen, Zheng ; Han, Cheng-Kun ; Pan, Ling-Ling ; Zhang, Hui-Jie ; Ma, Zhi-Min ; Huang, Zhu-Feng ; Chen, Shi ; Zhuang, Xiong-Jie ; Li, Zhi-Bin ; Li, Xiao-Ying ; Li, Xue-Jun ; Yang, Shu-Yu</creatorcontrib><description>Background and Aim
Liver enzymes including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) are well recognized as surrogate makers reflecting non-alcoholic fatty liver disease (NAFLD). However, the associations of serum ALT, AST and GGT with hepatic lipid contents are not well established. The aim of this study was to investigate the relationship between liver enzymes and intrahepatic triglyceride (IHTG) contents, and explore the feasibility in using liver enzymes to reflect accumulation of IHTG in obese subjects.
Methods
A cross-sectional analysis was conducted in 475 obese adults aged 40–65 years. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose and lipid profiles were measured. The liver triglyceride contents of subjects were determined by
1
H-MRS.
Results
Serum ALT, AST and GGT were positively correlated with IHTG contents (
p
< 0.01). Serum ALT, AST and GGT levels at the highest quartile of IHTG contents were significantly elevated as compared with those in the lowest quartile (
p
< 0.01). Multivariate linear regression analysis demonstrated that serum ALT, but not AST or GGT was independently associated with IHTG contents. By logistic regression analysis, the odds ratio for higher IHTG contents was increased by 1.464 times/1 SD increase in serum ALT level after adjusting for multiple confounding factors [OR (95 % CI) 2.464 (1.584–3.834)]. However, these relationships could not be observed between serum AST or GGT with IHTG contents.
Conclusions
Serum ALT level is independently correlated with the hepatic triglyceride contents in obese subjects and more appropriate to be used as a predictor for the degree of NAFLD rather than AST and GGT.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-014-3214-3</identifier><identifier>PMID: 24861033</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Alanine Transaminase - blood ; Aspartate ; Biochemistry ; Enzymes ; Female ; Gastroenterology ; Hepatology ; Humans ; Liver ; Liver - chemistry ; Liver - metabolism ; Liver diseases ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Obesity - blood ; Obesity - metabolism ; Oncology ; Original Article ; Transplant Surgery ; Triglycerides</subject><ispartof>Digestive diseases and sciences, 2014-10, Vol.59 (10), p.2470-2476</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-a0a95befff9d15e0cef0c46ac6387f15a84235a8e794d7e589089eaa408129c83</citedby><cites>FETCH-LOGICAL-c542t-a0a95befff9d15e0cef0c46ac6387f15a84235a8e794d7e589089eaa408129c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-014-3214-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-014-3214-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24861033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zheng</creatorcontrib><creatorcontrib>Han, Cheng-Kun</creatorcontrib><creatorcontrib>Pan, Ling-Ling</creatorcontrib><creatorcontrib>Zhang, Hui-Jie</creatorcontrib><creatorcontrib>Ma, Zhi-Min</creatorcontrib><creatorcontrib>Huang, Zhu-Feng</creatorcontrib><creatorcontrib>Chen, Shi</creatorcontrib><creatorcontrib>Zhuang, Xiong-Jie</creatorcontrib><creatorcontrib>Li, Zhi-Bin</creatorcontrib><creatorcontrib>Li, Xiao-Ying</creatorcontrib><creatorcontrib>Li, Xue-Jun</creatorcontrib><creatorcontrib>Yang, Shu-Yu</creatorcontrib><title>Serum Alanine Aminotransferase Independently Correlates with Intrahepatic Triglyceride Contents in Obese Subjects</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background and Aim
Liver enzymes including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) are well recognized as surrogate makers reflecting non-alcoholic fatty liver disease (NAFLD). However, the associations of serum ALT, AST and GGT with hepatic lipid contents are not well established. The aim of this study was to investigate the relationship between liver enzymes and intrahepatic triglyceride (IHTG) contents, and explore the feasibility in using liver enzymes to reflect accumulation of IHTG in obese subjects.
Methods
A cross-sectional analysis was conducted in 475 obese adults aged 40–65 years. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose and lipid profiles were measured. The liver triglyceride contents of subjects were determined by
1
H-MRS.
Results
Serum ALT, AST and GGT were positively correlated with IHTG contents (
p
< 0.01). Serum ALT, AST and GGT levels at the highest quartile of IHTG contents were significantly elevated as compared with those in the lowest quartile (
p
< 0.01). Multivariate linear regression analysis demonstrated that serum ALT, but not AST or GGT was independently associated with IHTG contents. By logistic regression analysis, the odds ratio for higher IHTG contents was increased by 1.464 times/1 SD increase in serum ALT level after adjusting for multiple confounding factors [OR (95 % CI) 2.464 (1.584–3.834)]. However, these relationships could not be observed between serum AST or GGT with IHTG contents.
Conclusions
Serum ALT level is independently correlated with the hepatic triglyceride contents in obese subjects and more appropriate to be used as a predictor for the degree of NAFLD rather than AST and GGT.</description><subject>Alanine Transaminase - blood</subject><subject>Aspartate</subject><subject>Biochemistry</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - chemistry</subject><subject>Liver - metabolism</subject><subject>Liver diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Obesity - metabolism</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Transplant Surgery</subject><subject>Triglycerides</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkk1r3DAQhkVpabZpf0AvxdBLL071YevjuCz9CARySHoWWnm00WLLG8mm7L_PuJuWtLQUwUhonneYkV5C3jJ6wShVHwujktOasqYWfAnPyIq1StS8lfo5WVEm8cyYPCOvStlTSo1i8iU5442WjAqxIvc3kOehWvcuxQTVeohpnLJLJUB2BarL1MEBMKSpP1abMWfo3QSl-h6nO8wiewcHN0Vf3ea4648ecuwAyTShplQxVddbwEo383YPfiqvyYvg-gJvHvdz8u3zp9vN1_rq-svlZn1V-7bhU-2oM-0WQgimYy1QD4H6RjovhVaBtU43XGAEZZpOQasN1Qaca6hm3HgtzsmHU91DHu9nKJMdYvHQ46QwzsUybZTQVAv5f7SVzChl9IK-_wPdj3NOOMgPSjKumyfUzvVgYwrLm_qlqF0rbK_h-CtIXfyFwtXBEP2YIES8_03ATgKfx1IyBHvIcXD5aBm1iyPsyREWHWEXR1iBmnePDc_bAbpfip8WQICfgIKptIP8ZKJ_Vn0AkSW_rQ</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Chen, Zheng</creator><creator>Han, Cheng-Kun</creator><creator>Pan, Ling-Ling</creator><creator>Zhang, Hui-Jie</creator><creator>Ma, Zhi-Min</creator><creator>Huang, Zhu-Feng</creator><creator>Chen, Shi</creator><creator>Zhuang, Xiong-Jie</creator><creator>Li, Zhi-Bin</creator><creator>Li, Xiao-Ying</creator><creator>Li, Xue-Jun</creator><creator>Yang, Shu-Yu</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20141001</creationdate><title>Serum Alanine Aminotransferase Independently Correlates with Intrahepatic Triglyceride Contents in Obese Subjects</title><author>Chen, Zheng ; Han, Cheng-Kun ; Pan, Ling-Ling ; Zhang, Hui-Jie ; Ma, Zhi-Min ; Huang, Zhu-Feng ; Chen, Shi ; Zhuang, Xiong-Jie ; Li, Zhi-Bin ; Li, Xiao-Ying ; Li, Xue-Jun ; Yang, Shu-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-a0a95befff9d15e0cef0c46ac6387f15a84235a8e794d7e589089eaa408129c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alanine Transaminase - blood</topic><topic>Aspartate</topic><topic>Biochemistry</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - chemistry</topic><topic>Liver - metabolism</topic><topic>Liver diseases</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Obesity - metabolism</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Transplant Surgery</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zheng</creatorcontrib><creatorcontrib>Han, Cheng-Kun</creatorcontrib><creatorcontrib>Pan, Ling-Ling</creatorcontrib><creatorcontrib>Zhang, Hui-Jie</creatorcontrib><creatorcontrib>Ma, Zhi-Min</creatorcontrib><creatorcontrib>Huang, Zhu-Feng</creatorcontrib><creatorcontrib>Chen, Shi</creatorcontrib><creatorcontrib>Zhuang, Xiong-Jie</creatorcontrib><creatorcontrib>Li, Zhi-Bin</creatorcontrib><creatorcontrib>Li, Xiao-Ying</creatorcontrib><creatorcontrib>Li, Xue-Jun</creatorcontrib><creatorcontrib>Yang, Shu-Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zheng</au><au>Han, Cheng-Kun</au><au>Pan, Ling-Ling</au><au>Zhang, Hui-Jie</au><au>Ma, Zhi-Min</au><au>Huang, Zhu-Feng</au><au>Chen, Shi</au><au>Zhuang, Xiong-Jie</au><au>Li, Zhi-Bin</au><au>Li, Xiao-Ying</au><au>Li, Xue-Jun</au><au>Yang, Shu-Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Alanine Aminotransferase Independently Correlates with Intrahepatic Triglyceride Contents in Obese Subjects</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>59</volume><issue>10</issue><spage>2470</spage><epage>2476</epage><pages>2470-2476</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Background and Aim
Liver enzymes including serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) are well recognized as surrogate makers reflecting non-alcoholic fatty liver disease (NAFLD). However, the associations of serum ALT, AST and GGT with hepatic lipid contents are not well established. The aim of this study was to investigate the relationship between liver enzymes and intrahepatic triglyceride (IHTG) contents, and explore the feasibility in using liver enzymes to reflect accumulation of IHTG in obese subjects.
Methods
A cross-sectional analysis was conducted in 475 obese adults aged 40–65 years. Anthropometric parameters and blood biochemical indexes including liver enzymes, glucose and lipid profiles were measured. The liver triglyceride contents of subjects were determined by
1
H-MRS.
Results
Serum ALT, AST and GGT were positively correlated with IHTG contents (
p
< 0.01). Serum ALT, AST and GGT levels at the highest quartile of IHTG contents were significantly elevated as compared with those in the lowest quartile (
p
< 0.01). Multivariate linear regression analysis demonstrated that serum ALT, but not AST or GGT was independently associated with IHTG contents. By logistic regression analysis, the odds ratio for higher IHTG contents was increased by 1.464 times/1 SD increase in serum ALT level after adjusting for multiple confounding factors [OR (95 % CI) 2.464 (1.584–3.834)]. However, these relationships could not be observed between serum AST or GGT with IHTG contents.
Conclusions
Serum ALT level is independently correlated with the hepatic triglyceride contents in obese subjects and more appropriate to be used as a predictor for the degree of NAFLD rather than AST and GGT.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24861033</pmid><doi>10.1007/s10620-014-3214-3</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2014-10, Vol.59 (10), p.2470-2476 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Alanine Transaminase - blood Aspartate Biochemistry Enzymes Female Gastroenterology Hepatology Humans Liver Liver - chemistry Liver - metabolism Liver diseases Male Medicine Medicine & Public Health Middle Aged Obesity - blood Obesity - metabolism Oncology Original Article Transplant Surgery Triglycerides |
| title | Serum Alanine Aminotransferase Independently Correlates with Intrahepatic Triglyceride Contents in Obese Subjects |
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