Physiological effects of roflumilast at rest and during exercise in COPD

The purpose of this study was to investigate the effects of 500 μg roflumilast, taken once daily for 12 weeks, on airway physiology during rest and exercise in patients with moderate-to-severe chronic obstructive pulmonary disease. This randomised, double-blind, placebo-controlled, parallel-group st...

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Veröffentlicht in:	The European respiratory journal 2012-05, Vol.39 (5), p.1104-1112
Hauptverfasser:	O'DONNELL, Denis E, BREDENBRÖKER, Dirk, BROSE, Manja, WEBB, Katherine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Airway Resistance - drug effects Airway Resistance - physiology Aminopyridines - administration & dosage Benzamides - administration & dosage Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Bronchodilator Agents - therapeutic use Chronic obstructive pulmonary disease, asthma Cyclopropanes - administration & dosage Drug Administration Schedule Dyspnea - drug therapy Dyspnea - physiopathology Exercise - physiology Female Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Phosphodiesterase 4 Inhibitors - administration & dosage Physical Endurance - drug effects Pneumology Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory Function Tests Rest - physiology Severity of Illness Index
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