Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015
Classical swine fever (CSF), a highly contagious viral disease affecting domestic and wild pigs in many developing countries, is now considered endemic in Mongolia, with 14 recent outbreaks in 2007, 2008, 2011, 2012, 2014, and 2015. For the first time, CSF viruses isolated from these 14 outbreaks we...
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| Veröffentlicht in: | Virus genes 2017-06, Vol.53 (3), p.418-425 |
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| creator | Enkhbold, Bazarragchaa Shatar, Munkhduuren Wakamori, Shiho Tamura, Tomokazu Hiono, Takahiro Matsuno, Keita Okamatsu, Masatoshi Umemura, Takashi Damdinjav, Batchuluun Sakoda, Yoshihiro |
| description | Classical swine fever (CSF), a highly contagious viral disease affecting domestic and wild pigs in many developing countries, is now considered endemic in Mongolia, with 14 recent outbreaks in 2007, 2008, 2011, 2012, 2014, and 2015. For the first time, CSF viruses isolated from these 14 outbreaks were analyzed to assess their molecular epidemiology and pathogenicity in pigs. Based on the nucleotide sequences of their 5′-untranslated region, isolates were phylogenetically classified as either sub-genotypes 2.1b or 2.2, and the 2014 and 2015 isolates, which were classified as 2.1b, were closely related to isolates from China and Korea. In addition, at least three different viruses classified as 2.1b circulated in Mongolia. Experimental infection of the representative isolate in 2014 demonstrated moderate pathogenicity in 4-week-old pigs, with relatively mild clinical signs. Understanding the diversity of circulating CSF viruses gleans insight into disease dynamics and evolution, and may inform the design of effective CSF control strategies in Mongolia. |
| doi_str_mv | 10.1007/s11262-017-1442-2 |
| format | Article |
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For the first time, CSF viruses isolated from these 14 outbreaks were analyzed to assess their molecular epidemiology and pathogenicity in pigs. Based on the nucleotide sequences of their 5′-untranslated region, isolates were phylogenetically classified as either sub-genotypes 2.1b or 2.2, and the 2014 and 2015 isolates, which were classified as 2.1b, were closely related to isolates from China and Korea. In addition, at least three different viruses classified as 2.1b circulated in Mongolia. Experimental infection of the representative isolate in 2014 demonstrated moderate pathogenicity in 4-week-old pigs, with relatively mild clinical signs. Understanding the diversity of circulating CSF viruses gleans insight into disease dynamics and evolution, and may inform the design of effective CSF control strategies in Mongolia.</description><identifier>ISSN: 0920-8569</identifier><identifier>EISSN: 1572-994X</identifier><identifier>DOI: 10.1007/s11262-017-1442-2</identifier><identifier>PMID: 28260187</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Base Sequence ; Biomedical and Life Sciences ; Biomedicine ; Cell Line ; China ; Classical Swine Fever - epidemiology ; Classical Swine Fever - pathology ; Classical Swine Fever - physiopathology ; Classical Swine Fever - virology ; Classical swine fever virus - classification ; Classical swine fever virus - genetics ; Classical swine fever virus - isolation & purification ; Disease Models, Animal ; Disease Outbreaks ; Genotype ; Medical Microbiology ; Molecular Epidemiology ; Mongolia - epidemiology ; Phylogeny ; Plant Sciences ; Republic of Korea ; Sus scrofa - virology ; Swine ; Swine Diseases - virology ; Virology ; Virulence - genetics</subject><ispartof>Virus genes, 2017-06, Vol.53 (3), p.418-425</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Virus Genes is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-116f445f2a969ae3eb9d06b3c8d7f76ec9682e472bf36628d5998ddf3509eab63</citedby><cites>FETCH-LOGICAL-c471t-116f445f2a969ae3eb9d06b3c8d7f76ec9682e472bf36628d5998ddf3509eab63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11262-017-1442-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11262-017-1442-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28260187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Enkhbold, Bazarragchaa</creatorcontrib><creatorcontrib>Shatar, Munkhduuren</creatorcontrib><creatorcontrib>Wakamori, Shiho</creatorcontrib><creatorcontrib>Tamura, Tomokazu</creatorcontrib><creatorcontrib>Hiono, Takahiro</creatorcontrib><creatorcontrib>Matsuno, Keita</creatorcontrib><creatorcontrib>Okamatsu, Masatoshi</creatorcontrib><creatorcontrib>Umemura, Takashi</creatorcontrib><creatorcontrib>Damdinjav, Batchuluun</creatorcontrib><creatorcontrib>Sakoda, Yoshihiro</creatorcontrib><title>Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015</title><title>Virus genes</title><addtitle>Virus Genes</addtitle><addtitle>Virus Genes</addtitle><description>Classical swine fever (CSF), a highly contagious viral disease affecting domestic and wild pigs in many developing countries, is now considered endemic in Mongolia, with 14 recent outbreaks in 2007, 2008, 2011, 2012, 2014, and 2015. For the first time, CSF viruses isolated from these 14 outbreaks were analyzed to assess their molecular epidemiology and pathogenicity in pigs. Based on the nucleotide sequences of their 5′-untranslated region, isolates were phylogenetically classified as either sub-genotypes 2.1b or 2.2, and the 2014 and 2015 isolates, which were classified as 2.1b, were closely related to isolates from China and Korea. In addition, at least three different viruses classified as 2.1b circulated in Mongolia. Experimental infection of the representative isolate in 2014 demonstrated moderate pathogenicity in 4-week-old pigs, with relatively mild clinical signs. Understanding the diversity of circulating CSF viruses gleans insight into disease dynamics and evolution, and may inform the design of effective CSF control strategies in Mongolia.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Line</subject><subject>China</subject><subject>Classical Swine Fever - epidemiology</subject><subject>Classical Swine Fever - pathology</subject><subject>Classical Swine Fever - physiopathology</subject><subject>Classical Swine Fever - virology</subject><subject>Classical swine fever virus - classification</subject><subject>Classical swine fever virus - genetics</subject><subject>Classical swine fever virus - isolation & purification</subject><subject>Disease Models, Animal</subject><subject>Disease Outbreaks</subject><subject>Genotype</subject><subject>Medical Microbiology</subject><subject>Molecular Epidemiology</subject><subject>Mongolia - epidemiology</subject><subject>Phylogeny</subject><subject>Plant Sciences</subject><subject>Republic of Korea</subject><subject>Sus scrofa - 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epidemiology</topic><topic>Classical Swine Fever - pathology</topic><topic>Classical Swine Fever - physiopathology</topic><topic>Classical Swine Fever - virology</topic><topic>Classical swine fever virus - classification</topic><topic>Classical swine fever virus - genetics</topic><topic>Classical swine fever virus - isolation & purification</topic><topic>Disease Models, Animal</topic><topic>Disease Outbreaks</topic><topic>Genotype</topic><topic>Medical Microbiology</topic><topic>Molecular Epidemiology</topic><topic>Mongolia - epidemiology</topic><topic>Phylogeny</topic><topic>Plant Sciences</topic><topic>Republic of Korea</topic><topic>Sus scrofa - virology</topic><topic>Swine</topic><topic>Swine Diseases - virology</topic><topic>Virology</topic><topic>Virulence - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Enkhbold, Bazarragchaa</creatorcontrib><creatorcontrib>Shatar, Munkhduuren</creatorcontrib><creatorcontrib>Wakamori, Shiho</creatorcontrib><creatorcontrib>Tamura, Tomokazu</creatorcontrib><creatorcontrib>Hiono, Takahiro</creatorcontrib><creatorcontrib>Matsuno, Keita</creatorcontrib><creatorcontrib>Okamatsu, Masatoshi</creatorcontrib><creatorcontrib>Umemura, Takashi</creatorcontrib><creatorcontrib>Damdinjav, Batchuluun</creatorcontrib><creatorcontrib>Sakoda, Yoshihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virus genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enkhbold, Bazarragchaa</au><au>Shatar, Munkhduuren</au><au>Wakamori, Shiho</au><au>Tamura, Tomokazu</au><au>Hiono, Takahiro</au><au>Matsuno, Keita</au><au>Okamatsu, Masatoshi</au><au>Umemura, Takashi</au><au>Damdinjav, Batchuluun</au><au>Sakoda, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015</atitle><jtitle>Virus genes</jtitle><stitle>Virus Genes</stitle><addtitle>Virus Genes</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>53</volume><issue>3</issue><spage>418</spage><epage>425</epage><pages>418-425</pages><issn>0920-8569</issn><eissn>1572-994X</eissn><abstract>Classical swine fever (CSF), a highly contagious viral disease affecting domestic and wild pigs in many developing countries, is now considered endemic in Mongolia, with 14 recent outbreaks in 2007, 2008, 2011, 2012, 2014, and 2015. For the first time, CSF viruses isolated from these 14 outbreaks were analyzed to assess their molecular epidemiology and pathogenicity in pigs. Based on the nucleotide sequences of their 5′-untranslated region, isolates were phylogenetically classified as either sub-genotypes 2.1b or 2.2, and the 2014 and 2015 isolates, which were classified as 2.1b, were closely related to isolates from China and Korea. In addition, at least three different viruses classified as 2.1b circulated in Mongolia. Experimental infection of the representative isolate in 2014 demonstrated moderate pathogenicity in 4-week-old pigs, with relatively mild clinical signs. Understanding the diversity of circulating CSF viruses gleans insight into disease dynamics and evolution, and may inform the design of effective CSF control strategies in Mongolia.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28260187</pmid><doi>10.1007/s11262-017-1442-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Base Sequence Biomedical and Life Sciences Biomedicine Cell Line China Classical Swine Fever - epidemiology Classical Swine Fever - pathology Classical Swine Fever - physiopathology Classical Swine Fever - virology Classical swine fever virus - classification Classical swine fever virus - genetics Classical swine fever virus - isolation & purification Disease Models, Animal Disease Outbreaks Genotype Medical Microbiology Molecular Epidemiology Mongolia - epidemiology Phylogeny Plant Sciences Republic of Korea Sus scrofa - virology Swine Swine Diseases - virology Virology Virulence - genetics |
| title | Genetic and virulence characterization of classical swine fever viruses isolated in Mongolia from 2007 to 2015 |
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