Exhaustive Training Leads to Hepatic Fat Accumulation

Recently, we demonstrated that an overtraining (OT) protocol for mice based on downhill running sessions increased the hepatic phosphorylation of 70‐kDa ribosomal protein S6 kinase 1 (S6K1; Thr389), a downstream target of the mammalian target of rapamycin complex 1 (mTORC1). In liver, the overactiva...

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Veröffentlicht in:	Journal of cellular physiology 2017-08, Vol.232 (8), p.2094-2103
Hauptverfasser:	da Rocha, Alisson L., Pinto, Ana P., Teixeira, Giovana R., Pereira, Bruno C., Oliveira, Luciana C., Silva, Adriana C., Morais, Gustavo P., Cintra, Dennys E., Pauli, José R., da Silva, Adelino S. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - metabolism Adipose Tissue - metabolism Adipose Tissue - pathology AMP-Activated Protein Kinases - metabolism Animals Energy Metabolism Fatty Acid Synthase, Type I - metabolism Fatty Liver - etiology Fatty Liver - metabolism Fatty Liver - pathology Liver - metabolism Liver - pathology Male Mechanistic Target of Rapamycin Complex 1 Mice, Inbred C57BL Multiprotein Complexes - metabolism Phosphorylation Physical Conditioning, Animal - adverse effects Physical Conditioning, Animal - methods Physical Endurance Running Signal Transduction Sterol Regulatory Element Binding Protein 1 - metabolism TOR Serine-Threonine Kinases - metabolism Training
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