Effects of Weight Loss Speed on Kidney Function Differ Depending on Body Mass Index in Nondiabetic Healthy People: A Prospective Cohort: e0143434

Background Obesity is associated with diabetes mellitus and cardiovascular diseases. However, it has been reported that weight loss is associated with incident chronic kidney disease (CKD) in healthy males. The purpose of this prospective cohort study is to investigate the effects of weight loss on kidney function in healthy people in terms of body mass index (BMI) and gender. Methods A total of 8447 nondiabetic healthy people were enrolled in the Saitama Cardiometabolic Disease and Organ Impairment Study, Japan. Relationships between estimated glomerular filtration rate (eGFR) change, BMI, and BMI change were evaluated using 3D-scatter plots with spline and generalized additive models (GAMs) adjusted for baseline characteristics. Results The subjects were stratified into four groups according to BMI. The mean plus or minus standard deviations for males and females were, respectively, 40.11 plus or minus 9.49, and 40.3 plus or minus 9.71 years for age and 76.39 plus or minus 17.72 and 71.49 plus or minus 18.4 ml/min/1.73m2 for eGFR. GAMs showed that a decreasing BMI change (