Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia

BCR-ABL kinase inhibitors are employed successfully for chronic myeloid leukemia (CML) treatment. However, resistant disease and persistence of BCR-ABL1-independent leukemia stem and progenitor cells (LSPC) remain clinical challenges. The receptor tyrosine kinase Axl can mediate survival and therapy...

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Veröffentlicht in:	Clinical cancer research 2017-05, Vol.23 (9), p.2289-2300
Hauptverfasser:	Ben-Batalla, Isabel, Erdmann, Robert, Jørgensen, Heather, Mitchell, Rebecca, Ernst, Thomas, von Amsberg, Gunhild, Schafhausen, Philippe, Velthaus, Janna L, Rankin, Stephen, Clark, Richard E, Koschmieder, Steffen, Schultze, Alexander, Mitra, Subir, Vandenberghe, Peter, Brümmendorf, Tim H, Carmeliet, Peter, Hochhaus, Andreas, Pantel, Klaus, Bokemeyer, Carsten, Helgason, G Vignir, Holyoake, Tessa L, Loges, Sonja
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis - drug effects Axl protein BCR-ABL protein Benzocycloheptenes - administration & dosage Cancer CD34 antigen Cells (biology) Chronic myeloid leukemia Clinical trials Drug Resistance, Neoplasm - genetics Enzyme inhibitors Experimental design Fusion protein Fusion Proteins, bcr-abl - antagonists & inhibitors Fusion Proteins, bcr-abl - genetics Humans Imatinib Imatinib Mesylate - administration & dosage Imidazoles - administration & dosage In vivo methods and tests Inhibition Inhibitors K562 Cells Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Medical research Medical treatment Mice Mutation Myeloid leukemia Patients Pharmacology Progenitor cells Protein Kinase Inhibitors - administration & dosage Protein-tyrosine kinase receptors Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Pyridazines - administration & dosage Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Small Molecule Libraries - administration & dosage Stat5 protein Stem cells Triazoles - administration & dosage Tyrosine
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