Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity: e0129513
Rationale Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA a...
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| Veröffentlicht in: | PloS one 2015-06, Vol.10 (6) |
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| creator | Toyama, Yoshiro Tanizawa, Kiminobu Kubo, Takeshi Chihara, Yuichi Harada, Yuka Murase, Kimihiko Azuma, Masanori Hamada, Satoshi Hitomi, Takefumi Handa, Tomohiro |
| description | Rationale Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention. Objectives To investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences. Methods Studied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography. Results Although the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) greater than or equal to 25 kg/m2 or visceral fat area greater than or equal to 100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation |
| doi_str_mv | 10.1371/journal.pone.0129513 |
| format | Article |
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Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention. Objectives To investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences. Methods Studied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography. Results Although the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) greater than or equal to 25 kg/m2 or visceral fat area greater than or equal to 100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation <90%, in addition to BMI, insulin resistance, and serum triglyceride values, was independently correlated with liver fat accumulation (R2 = 15.1%, P<0.001). In males, percent sleep time of oxygen saturation <90% was also a determining factor for alanine aminotransferase values regardless of visceral fat area. In contrast, OSA was not associated with liver fat accumulation or alanine aminotransferase values in females whether or not visceral obesity was absent. Conclusions Sex differences in the visceral fat-dependent impact of OSA on liver fat accumulation existed. Although the mechanisms are not known and ethnic differences may exist in addition to the specific criteria of visceral obesity in Japan, the treatment of male patients with OSA might be favorable from the viewpoint of preventing liver fat accumulation and liver dysfunction even in patients without obvious visceral fat accumulation.</description><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0129513</identifier><language>eng</language><ispartof>PloS one, 2015-06, Vol.10 (6)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids></links><search><creatorcontrib>Toyama, Yoshiro</creatorcontrib><creatorcontrib>Tanizawa, Kiminobu</creatorcontrib><creatorcontrib>Kubo, Takeshi</creatorcontrib><creatorcontrib>Chihara, Yuichi</creatorcontrib><creatorcontrib>Harada, Yuka</creatorcontrib><creatorcontrib>Murase, Kimihiko</creatorcontrib><creatorcontrib>Azuma, Masanori</creatorcontrib><creatorcontrib>Hamada, Satoshi</creatorcontrib><creatorcontrib>Hitomi, Takefumi</creatorcontrib><creatorcontrib>Handa, Tomohiro</creatorcontrib><title>Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity: e0129513</title><title>PloS one</title><description>Rationale Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention. Objectives To investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences. Methods Studied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography. Results Although the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) greater than or equal to 25 kg/m2 or visceral fat area greater than or equal to 100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation <90%, in addition to BMI, insulin resistance, and serum triglyceride values, was independently correlated with liver fat accumulation (R2 = 15.1%, P<0.001). In males, percent sleep time of oxygen saturation <90% was also a determining factor for alanine aminotransferase values regardless of visceral fat area. In contrast, OSA was not associated with liver fat accumulation or alanine aminotransferase values in females whether or not visceral obesity was absent. Conclusions Sex differences in the visceral fat-dependent impact of OSA on liver fat accumulation existed. Although the mechanisms are not known and ethnic differences may exist in addition to the specific criteria of visceral obesity in Japan, the treatment of male patients with OSA might be favorable from the viewpoint of preventing liver fat accumulation and liver dysfunction even in patients without obvious visceral fat accumulation.</description><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqVjs1KAzEUhYNQsFbfwMVddtMxmdj5cVekxUKhixG35ZreStpMEvNT9O0doS_Q1eF8nHM4jD0KXghZi6ejy8GiKbyzVHBRtnMhb9hYtLKcVSWXt-wuxiPnc9lU1Zid1r1HlcAdYPsZU8gq6TNBZ4g8LLwlBGdhM7AAK0ywUCr32WDSAx6MC3ttvyA56OgH0O7hQ0dFAc2wR1Gn3xegy417NjqgifRw0Qmbrpbvr28zH9x3pph2_X_XGLTkctyJpq1lXT83Ul4R_QOcjFJO</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Toyama, Yoshiro</creator><creator>Tanizawa, Kiminobu</creator><creator>Kubo, Takeshi</creator><creator>Chihara, Yuichi</creator><creator>Harada, Yuka</creator><creator>Murase, Kimihiko</creator><creator>Azuma, Masanori</creator><creator>Hamada, Satoshi</creator><creator>Hitomi, Takefumi</creator><creator>Handa, Tomohiro</creator><scope>7TS</scope></search><sort><creationdate>20150601</creationdate><title>Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity: e0129513</title><author>Toyama, Yoshiro ; Tanizawa, Kiminobu ; Kubo, Takeshi ; Chihara, Yuichi ; Harada, Yuka ; Murase, Kimihiko ; Azuma, Masanori ; Hamada, Satoshi ; Hitomi, Takefumi ; Handa, Tomohiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_18973774833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toyama, Yoshiro</creatorcontrib><creatorcontrib>Tanizawa, Kiminobu</creatorcontrib><creatorcontrib>Kubo, Takeshi</creatorcontrib><creatorcontrib>Chihara, Yuichi</creatorcontrib><creatorcontrib>Harada, Yuka</creatorcontrib><creatorcontrib>Murase, Kimihiko</creatorcontrib><creatorcontrib>Azuma, Masanori</creatorcontrib><creatorcontrib>Hamada, Satoshi</creatorcontrib><creatorcontrib>Hitomi, Takefumi</creatorcontrib><creatorcontrib>Handa, Tomohiro</creatorcontrib><collection>Physical Education Index</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toyama, Yoshiro</au><au>Tanizawa, Kiminobu</au><au>Kubo, Takeshi</au><au>Chihara, Yuichi</au><au>Harada, Yuka</au><au>Murase, Kimihiko</au><au>Azuma, Masanori</au><au>Hamada, Satoshi</au><au>Hitomi, Takefumi</au><au>Handa, Tomohiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity: e0129513</atitle><jtitle>PloS one</jtitle><date>2015-06-01</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><eissn>1932-6203</eissn><abstract>Rationale Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention. Objectives To investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences. Methods Studied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography. Results Although the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) greater than or equal to 25 kg/m2 or visceral fat area greater than or equal to 100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation <90%, in addition to BMI, insulin resistance, and serum triglyceride values, was independently correlated with liver fat accumulation (R2 = 15.1%, P<0.001). In males, percent sleep time of oxygen saturation <90% was also a determining factor for alanine aminotransferase values regardless of visceral fat area. In contrast, OSA was not associated with liver fat accumulation or alanine aminotransferase values in females whether or not visceral obesity was absent. Conclusions Sex differences in the visceral fat-dependent impact of OSA on liver fat accumulation existed. Although the mechanisms are not known and ethnic differences may exist in addition to the specific criteria of visceral obesity in Japan, the treatment of male patients with OSA might be favorable from the viewpoint of preventing liver fat accumulation and liver dysfunction even in patients without obvious visceral fat accumulation.</abstract><doi>10.1371/journal.pone.0129513</doi></addata></record> |
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| title | Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity: e0129513 |
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