GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study
The role of glucose-stimulated release of GLP-1 in the development of obesity and type 2 diabetes is unclear. We assessed GLP-1 response to oral glucose in a large study population of lean and obese men and women with normal and impaired glucose regulation. Circulating concentrations of glucose, ins...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2015-07, Vol.64 (7), p.2513-2525 |
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| creator | Færch, Kristine Torekov, Signe S Vistisen, Dorte Johansen, Nanna B Witte, Daniel R Jonsson, Anna Pedersen, Oluf Hansen, Torben Lauritzen, Torsten Sandbæk, Annelli Holst, Jens Juul Jørgensen, Marit E |
| description | The role of glucose-stimulated release of GLP-1 in the development of obesity and type 2 diabetes is unclear. We assessed GLP-1 response to oral glucose in a large study population of lean and obese men and women with normal and impaired glucose regulation. Circulating concentrations of glucose, insulin, and GLP-1 during an oral glucose tolerance test (OGTT) were analyzed in individuals with normal glucose tolerance (NGT) (n = 774), prediabetes (n = 525), or screen-detected type 2 diabetes (n = 163) who attended the Danish ADDITION-PRO study (n = 1,462). Compared with individuals with NGT, women with prediabetes or type 2 diabetes had 25% lower GLP-1 response to an OGTT, and both men and women with prediabetes or type 2 diabetes had 16-21% lower 120-min GLP-1 concentrations independent of age and obesity. Obese and overweight individuals had up to 20% reduced GLP-1 response to oral glucose compared with normal weight individuals independent of glucose tolerance status. Higher GLP-1 responses were associated with better insulin sensitivity and β-cell function, older age, and lesser degree of obesity. Our findings indicate that a reduction in GLP-1 response to oral glucose occurs prior to the development of type 2 diabetes and obesity, which can have consequences for early prevention strategies for diabetes. |
| doi_str_mv | 10.2337/db14-1751 |
| format | Article |
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We assessed GLP-1 response to oral glucose in a large study population of lean and obese men and women with normal and impaired glucose regulation. Circulating concentrations of glucose, insulin, and GLP-1 during an oral glucose tolerance test (OGTT) were analyzed in individuals with normal glucose tolerance (NGT) (n = 774), prediabetes (n = 525), or screen-detected type 2 diabetes (n = 163) who attended the Danish ADDITION-PRO study (n = 1,462). Compared with individuals with NGT, women with prediabetes or type 2 diabetes had 25% lower GLP-1 response to an OGTT, and both men and women with prediabetes or type 2 diabetes had 16-21% lower 120-min GLP-1 concentrations independent of age and obesity. Obese and overweight individuals had up to 20% reduced GLP-1 response to oral glucose compared with normal weight individuals independent of glucose tolerance status. Higher GLP-1 responses were associated with better insulin sensitivity and β-cell function, older age, and lesser degree of obesity. Our findings indicate that a reduction in GLP-1 response to oral glucose occurs prior to the development of type 2 diabetes and obesity, which can have consequences for early prevention strategies for diabetes.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db14-1751</identifier><identifier>PMID: 25677912</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Age Factors ; Aged ; Blood Glucose - analysis ; Body Mass Index ; Cells ; Diabetes ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Gender ; Glucagon-Like Peptide 1 - blood ; Glucose ; Glucose Tolerance Test ; Humans ; Insulin ; Insulin - blood ; Male ; Middle Aged ; Obesity ; Obesity - metabolism ; Prediabetic State - metabolism ; Sex Characteristics ; Waist Circumference</subject><ispartof>Diabetes (New York, N.Y.), 2015-07, Vol.64 (7), p.2513-2525</ispartof><rights>2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</rights><rights>Copyright American Diabetes Association Jul 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-d500c4d07c273d11663e5ec78dc0b23c0b5a8edf813fbb25cc2bda4a82c000713</citedby><cites>FETCH-LOGICAL-c447t-d500c4d07c273d11663e5ec78dc0b23c0b5a8edf813fbb25cc2bda4a82c000713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25677912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Færch, Kristine</creatorcontrib><creatorcontrib>Torekov, Signe S</creatorcontrib><creatorcontrib>Vistisen, Dorte</creatorcontrib><creatorcontrib>Johansen, Nanna B</creatorcontrib><creatorcontrib>Witte, Daniel R</creatorcontrib><creatorcontrib>Jonsson, Anna</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Lauritzen, Torsten</creatorcontrib><creatorcontrib>Sandbæk, Annelli</creatorcontrib><creatorcontrib>Holst, Jens Juul</creatorcontrib><creatorcontrib>Jørgensen, Marit E</creatorcontrib><title>GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>The role of glucose-stimulated release of GLP-1 in the development of obesity and type 2 diabetes is unclear. We assessed GLP-1 response to oral glucose in a large study population of lean and obese men and women with normal and impaired glucose regulation. Circulating concentrations of glucose, insulin, and GLP-1 during an oral glucose tolerance test (OGTT) were analyzed in individuals with normal glucose tolerance (NGT) (n = 774), prediabetes (n = 525), or screen-detected type 2 diabetes (n = 163) who attended the Danish ADDITION-PRO study (n = 1,462). Compared with individuals with NGT, women with prediabetes or type 2 diabetes had 25% lower GLP-1 response to an OGTT, and both men and women with prediabetes or type 2 diabetes had 16-21% lower 120-min GLP-1 concentrations independent of age and obesity. Obese and overweight individuals had up to 20% reduced GLP-1 response to oral glucose compared with normal weight individuals independent of glucose tolerance status. Higher GLP-1 responses were associated with better insulin sensitivity and β-cell function, older age, and lesser degree of obesity. Our findings indicate that a reduction in GLP-1 response to oral glucose occurs prior to the development of type 2 diabetes and obesity, which can have consequences for early prevention strategies for diabetes.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Body Mass Index</subject><subject>Cells</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Female</subject><subject>Gender</subject><subject>Glucagon-Like Peptide 1 - blood</subject><subject>Glucose</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Prediabetic State - metabolism</subject><subject>Sex Characteristics</subject><subject>Waist Circumference</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3EAMhofQ0mzSHvoHykAvCdTtfNiWnVvIplvDUi_ZDfRm5kOmDl57M2ND_D_ygzNu0hx6KQJpJD28MHoJ-cjZVyElfLOaxxGHhB-RBc9lHkkBv96QBWNchHkOx-TE-zvGWBriHTkWSQqQc7Egj6v1JuL0Bv2h7zzSoaelUy1dtaPpQ1_4sLOjQUubjm4c2kZpHNB_oVvjELtoGTozhP1uOiAVdPkKqM7SUqNvhunPu-jqdsRu1tIT3eLDBd39Rnq5XBa7ovwZbW5Kuh1GO70nb2vVevzwUk_J7ffr3dWPaF2uiqvLdWTiGIbIJoyZ2DIwAqTlPE0lJmggs4ZpIUNKVIa2zristRaJMUJbFatMmHAK4PKUnD3rHlx_P6Ifqn3jDbat6rAffcWzHCQAF9n_0TScMwOexgH9_A9614-uCx-ZKZnmkCcQqPNnyrjee4d1dXDNXrmp4qyaXa1mV6vZ1cB-elEc9R7tK_nXRvkEoueZow</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Færch, Kristine</creator><creator>Torekov, Signe S</creator><creator>Vistisen, Dorte</creator><creator>Johansen, Nanna B</creator><creator>Witte, Daniel R</creator><creator>Jonsson, Anna</creator><creator>Pedersen, Oluf</creator><creator>Hansen, Torben</creator><creator>Lauritzen, Torsten</creator><creator>Sandbæk, Annelli</creator><creator>Holst, Jens Juul</creator><creator>Jørgensen, Marit E</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20150701</creationdate><title>GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study</title><author>Færch, Kristine ; Torekov, Signe S ; Vistisen, Dorte ; Johansen, Nanna B ; Witte, Daniel R ; Jonsson, Anna ; Pedersen, Oluf ; Hansen, Torben ; Lauritzen, Torsten ; Sandbæk, Annelli ; Holst, Jens Juul ; Jørgensen, Marit E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-d500c4d07c273d11663e5ec78dc0b23c0b5a8edf813fbb25cc2bda4a82c000713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Blood Glucose - analysis</topic><topic>Body Mass Index</topic><topic>Cells</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Female</topic><topic>Gender</topic><topic>Glucagon-Like Peptide 1 - blood</topic><topic>Glucose</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Prediabetic State - metabolism</topic><topic>Sex Characteristics</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Færch, Kristine</creatorcontrib><creatorcontrib>Torekov, Signe S</creatorcontrib><creatorcontrib>Vistisen, Dorte</creatorcontrib><creatorcontrib>Johansen, Nanna B</creatorcontrib><creatorcontrib>Witte, Daniel R</creatorcontrib><creatorcontrib>Jonsson, Anna</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><creatorcontrib>Lauritzen, Torsten</creatorcontrib><creatorcontrib>Sandbæk, Annelli</creatorcontrib><creatorcontrib>Holst, Jens Juul</creatorcontrib><creatorcontrib>Jørgensen, Marit E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Færch, Kristine</au><au>Torekov, Signe S</au><au>Vistisen, Dorte</au><au>Johansen, Nanna B</au><au>Witte, Daniel R</au><au>Jonsson, Anna</au><au>Pedersen, Oluf</au><au>Hansen, Torben</au><au>Lauritzen, Torsten</au><au>Sandbæk, Annelli</au><au>Holst, Jens Juul</au><au>Jørgensen, Marit E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>64</volume><issue>7</issue><spage>2513</spage><epage>2525</epage><pages>2513-2525</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>The role of glucose-stimulated release of GLP-1 in the development of obesity and type 2 diabetes is unclear. We assessed GLP-1 response to oral glucose in a large study population of lean and obese men and women with normal and impaired glucose regulation. Circulating concentrations of glucose, insulin, and GLP-1 during an oral glucose tolerance test (OGTT) were analyzed in individuals with normal glucose tolerance (NGT) (n = 774), prediabetes (n = 525), or screen-detected type 2 diabetes (n = 163) who attended the Danish ADDITION-PRO study (n = 1,462). Compared with individuals with NGT, women with prediabetes or type 2 diabetes had 25% lower GLP-1 response to an OGTT, and both men and women with prediabetes or type 2 diabetes had 16-21% lower 120-min GLP-1 concentrations independent of age and obesity. Obese and overweight individuals had up to 20% reduced GLP-1 response to oral glucose compared with normal weight individuals independent of glucose tolerance status. Higher GLP-1 responses were associated with better insulin sensitivity and β-cell function, older age, and lesser degree of obesity. Our findings indicate that a reduction in GLP-1 response to oral glucose occurs prior to the development of type 2 diabetes and obesity, which can have consequences for early prevention strategies for diabetes.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>25677912</pmid><doi>10.2337/db14-1751</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes (New York, N.Y.), 2015-07, Vol.64 (7), p.2513-2525 |
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| subjects | Age Factors Aged Blood Glucose - analysis Body Mass Index Cells Diabetes Diabetes Mellitus, Type 2 - metabolism Female Gender Glucagon-Like Peptide 1 - blood Glucose Glucose Tolerance Test Humans Insulin Insulin - blood Male Middle Aged Obesity Obesity - metabolism Prediabetic State - metabolism Sex Characteristics Waist Circumference |
| title | GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study |
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