Patient‐reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial
BACKGROUND Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiatio...
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| Veröffentlicht in: | Cancer 2016-04, Vol.122 (8), p.1185-1200 |
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| container_title | Cancer |
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| creator | Capozzi, Lauren C. McNeely, Margaret L. Lau, Harold Y. Reimer, Raylene A. Giese‐Davis, Janine Fung, Tak S. Culos‐Reed, S. Nicole |
| description | BACKGROUND
Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiation of a lifestyle and progressive resistance exercise training intervention (during or after radiation therapy), as determined by intervention adherence and by comparing between‐group outcomes across 24 weeks.
METHODS
Sixty patients with head and neck cancer were randomized to engage in a 12‐week lifestyle intervention and progressive resistance‐training program either during radiation treatment or immediately after completion. The primary outcome of body composition—specifically, lean body mass, body mass index, and body fat—as well as secondary outcomes of fitness, quality of life, depression, and nutrition status were evaluated.
RESULTS
The progressive resistance‐training intervention carried out during treatment did not significantly influence the primary outcome of body composition, despite a significant increase in weekly physical activity reported by the intervention group. A small‐to‐medium intervention effect was noted for some secondary outcomes, including fitness, quality of life, and nutrition status. Regardless of whether patients received the immediate or delayed progressive resistance‐training intervention, the analysis revealed a main effect of time on body composition, fitness, quality of life, depression, and nutritional scores.
CONCLUSIONS
Although the intervention during treatment did not reduce the loss of lean body mass, delaying the exercise program until after treatment completion was associated with improved intervention adherence, a finding with important clinical implications. Cancer 2016;122:1185–200. © 2016 American Cancer Society.
A physical activity lifestyle intervention for head and neck cancer patients during radiation treatment does not mitigate losses in body composition but may alleviate losses in fitness, QOL, and nutrition status. Intervention adherence supports improved patient participation and ease of participation post‐radiation rather than during radiation therapy. |
| doi_str_mv | 10.1002/cncr.29863 |
| format | Article |
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Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiation of a lifestyle and progressive resistance exercise training intervention (during or after radiation therapy), as determined by intervention adherence and by comparing between‐group outcomes across 24 weeks.
METHODS
Sixty patients with head and neck cancer were randomized to engage in a 12‐week lifestyle intervention and progressive resistance‐training program either during radiation treatment or immediately after completion. The primary outcome of body composition—specifically, lean body mass, body mass index, and body fat—as well as secondary outcomes of fitness, quality of life, depression, and nutrition status were evaluated.
RESULTS
The progressive resistance‐training intervention carried out during treatment did not significantly influence the primary outcome of body composition, despite a significant increase in weekly physical activity reported by the intervention group. A small‐to‐medium intervention effect was noted for some secondary outcomes, including fitness, quality of life, and nutrition status. Regardless of whether patients received the immediate or delayed progressive resistance‐training intervention, the analysis revealed a main effect of time on body composition, fitness, quality of life, depression, and nutritional scores.
CONCLUSIONS
Although the intervention during treatment did not reduce the loss of lean body mass, delaying the exercise program until after treatment completion was associated with improved intervention adherence, a finding with important clinical implications. Cancer 2016;122:1185–200. © 2016 American Cancer Society.
A physical activity lifestyle intervention for head and neck cancer patients during radiation treatment does not mitigate losses in body composition but may alleviate losses in fitness, QOL, and nutrition status. Intervention adherence supports improved patient participation and ease of participation post‐radiation rather than during radiation therapy.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.29863</identifier><identifier>PMID: 26828426</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Age Factors ; Aged ; Body Composition - physiology ; depression ; exercise ; Exercise Therapy - methods ; fatigue ; Female ; head and neck cancer ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - rehabilitation ; Head and Neck Neoplasms - therapy ; Humans ; Life Style ; Linear Models ; Male ; Middle Aged ; Nutritional Status ; Patient Outcome Assessment ; physical activity ; Physical Fitness - physiology ; physical functioning ; Prognosis ; Quality of Life ; Resistance Training - methods ; Self Report ; Sex Factors ; Statistics, Nonparametric ; Treatment Outcome</subject><ispartof>Cancer, 2016-04, Vol.122 (8), p.1185-1200</ispartof><rights>2016 American Cancer Society</rights><rights>2016 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3983-726e16bc886b6e41aeb15b0bd7077c84fda95df4ed843cbf23c760ec83559b9d3</citedby><cites>FETCH-LOGICAL-c3983-726e16bc886b6e41aeb15b0bd7077c84fda95df4ed843cbf23c760ec83559b9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.29863$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.29863$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26828426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capozzi, Lauren C.</creatorcontrib><creatorcontrib>McNeely, Margaret L.</creatorcontrib><creatorcontrib>Lau, Harold Y.</creatorcontrib><creatorcontrib>Reimer, Raylene A.</creatorcontrib><creatorcontrib>Giese‐Davis, Janine</creatorcontrib><creatorcontrib>Fung, Tak S.</creatorcontrib><creatorcontrib>Culos‐Reed, S. Nicole</creatorcontrib><title>Patient‐reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiation of a lifestyle and progressive resistance exercise training intervention (during or after radiation therapy), as determined by intervention adherence and by comparing between‐group outcomes across 24 weeks.
METHODS
Sixty patients with head and neck cancer were randomized to engage in a 12‐week lifestyle intervention and progressive resistance‐training program either during radiation treatment or immediately after completion. The primary outcome of body composition—specifically, lean body mass, body mass index, and body fat—as well as secondary outcomes of fitness, quality of life, depression, and nutrition status were evaluated.
RESULTS
The progressive resistance‐training intervention carried out during treatment did not significantly influence the primary outcome of body composition, despite a significant increase in weekly physical activity reported by the intervention group. A small‐to‐medium intervention effect was noted for some secondary outcomes, including fitness, quality of life, and nutrition status. Regardless of whether patients received the immediate or delayed progressive resistance‐training intervention, the analysis revealed a main effect of time on body composition, fitness, quality of life, depression, and nutritional scores.
CONCLUSIONS
Although the intervention during treatment did not reduce the loss of lean body mass, delaying the exercise program until after treatment completion was associated with improved intervention adherence, a finding with important clinical implications. Cancer 2016;122:1185–200. © 2016 American Cancer Society.
A physical activity lifestyle intervention for head and neck cancer patients during radiation treatment does not mitigate losses in body composition but may alleviate losses in fitness, QOL, and nutrition status. Intervention adherence supports improved patient participation and ease of participation post‐radiation rather than during radiation therapy.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Body Composition - physiology</subject><subject>depression</subject><subject>exercise</subject><subject>Exercise Therapy - methods</subject><subject>fatigue</subject><subject>Female</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - rehabilitation</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Life Style</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutritional Status</subject><subject>Patient Outcome Assessment</subject><subject>physical activity</subject><subject>Physical Fitness - physiology</subject><subject>physical functioning</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Resistance Training - methods</subject><subject>Self Report</subject><subject>Sex Factors</subject><subject>Statistics, Nonparametric</subject><subject>Treatment Outcome</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtu1TAUQC1ERV8LExaAPESoKf4kscMMPVFAqgqqQGIWOfaNanDsYDtqHyOW0H10V6wEtykMYeR75aNzBwehp5QcU0LYS-11PGadbPkDtKGkExWhNXuINoQQWTU1_7KPDlL6WlbBGv4I7bNWMlmzdoNuPqpswedfP68jzCFmMDgsWYcJ0hEegtnhMs8h2WyDP8LKG-yXHO9WnLLKS8LW43nVJHxp8wW-AGVWFPQ3rJXXEF_hc0iLK8gYw1R-MVzNLkSVQ9zhWOgw2R_lvA4-x-BcGeEKorYJcDmo3GO0NyqX4Mn9e4g-n7z5tH1XnX54-377-rTSvJO8EqwF2g5aynZooaYKBtoMZDCCCKFlPRrVNWaswcia62FkXIuWgJa8abqhM_wQPV-9cwzfF0i5n2zS4JzyEJbUU9kJLhpW8_-jQpKmJGlkQV-sqI4hpQhjP0c7qbjrKelvO_a3Hfu7jgV-du9dhgnMX_RPuALQFbi0Dnb_UPXbs-35Kv0NdpCuPA</recordid><startdate>20160415</startdate><enddate>20160415</enddate><creator>Capozzi, Lauren C.</creator><creator>McNeely, Margaret L.</creator><creator>Lau, Harold Y.</creator><creator>Reimer, Raylene A.</creator><creator>Giese‐Davis, Janine</creator><creator>Fung, Tak S.</creator><creator>Culos‐Reed, S. Nicole</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>20160415</creationdate><title>Patient‐reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial</title><author>Capozzi, Lauren C. ; McNeely, Margaret L. ; Lau, Harold Y. ; Reimer, Raylene A. ; Giese‐Davis, Janine ; Fung, Tak S. ; Culos‐Reed, S. Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3983-726e16bc886b6e41aeb15b0bd7077c84fda95df4ed843cbf23c760ec83559b9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Body Composition - physiology</topic><topic>depression</topic><topic>exercise</topic><topic>Exercise Therapy - methods</topic><topic>fatigue</topic><topic>Female</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - rehabilitation</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Life Style</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutritional Status</topic><topic>Patient Outcome Assessment</topic><topic>physical activity</topic><topic>Physical Fitness - physiology</topic><topic>physical functioning</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Resistance Training - methods</topic><topic>Self Report</topic><topic>Sex Factors</topic><topic>Statistics, Nonparametric</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capozzi, Lauren C.</creatorcontrib><creatorcontrib>McNeely, Margaret L.</creatorcontrib><creatorcontrib>Lau, Harold Y.</creatorcontrib><creatorcontrib>Reimer, Raylene A.</creatorcontrib><creatorcontrib>Giese‐Davis, Janine</creatorcontrib><creatorcontrib>Fung, Tak S.</creatorcontrib><creatorcontrib>Culos‐Reed, S. Nicole</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capozzi, Lauren C.</au><au>McNeely, Margaret L.</au><au>Lau, Harold Y.</au><au>Reimer, Raylene A.</au><au>Giese‐Davis, Janine</au><au>Fung, Tak S.</au><au>Culos‐Reed, S. Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patient‐reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2016-04-15</date><risdate>2016</risdate><volume>122</volume><issue>8</issue><spage>1185</spage><epage>1200</epage><pages>1185-1200</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>BACKGROUND
Patients with head and neck cancer experience loss of weight and muscle mass, decreased functioning, malnutrition, depression, and declines in quality of life during and after treatment. The purpose of this exploratory randomized study was to determine the optimal timing for the initiation of a lifestyle and progressive resistance exercise training intervention (during or after radiation therapy), as determined by intervention adherence and by comparing between‐group outcomes across 24 weeks.
METHODS
Sixty patients with head and neck cancer were randomized to engage in a 12‐week lifestyle intervention and progressive resistance‐training program either during radiation treatment or immediately after completion. The primary outcome of body composition—specifically, lean body mass, body mass index, and body fat—as well as secondary outcomes of fitness, quality of life, depression, and nutrition status were evaluated.
RESULTS
The progressive resistance‐training intervention carried out during treatment did not significantly influence the primary outcome of body composition, despite a significant increase in weekly physical activity reported by the intervention group. A small‐to‐medium intervention effect was noted for some secondary outcomes, including fitness, quality of life, and nutrition status. Regardless of whether patients received the immediate or delayed progressive resistance‐training intervention, the analysis revealed a main effect of time on body composition, fitness, quality of life, depression, and nutritional scores.
CONCLUSIONS
Although the intervention during treatment did not reduce the loss of lean body mass, delaying the exercise program until after treatment completion was associated with improved intervention adherence, a finding with important clinical implications. Cancer 2016;122:1185–200. © 2016 American Cancer Society.
A physical activity lifestyle intervention for head and neck cancer patients during radiation treatment does not mitigate losses in body composition but may alleviate losses in fitness, QOL, and nutrition status. Intervention adherence supports improved patient participation and ease of participation post‐radiation rather than during radiation therapy.</abstract><cop>United States</cop><pmid>26828426</pmid><doi>10.1002/cncr.29863</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 2016-04, Vol.122 (8), p.1185-1200 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library Free Content; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Age Factors Aged Body Composition - physiology depression exercise Exercise Therapy - methods fatigue Female head and neck cancer Head and Neck Neoplasms - pathology Head and Neck Neoplasms - rehabilitation Head and Neck Neoplasms - therapy Humans Life Style Linear Models Male Middle Aged Nutritional Status Patient Outcome Assessment physical activity Physical Fitness - physiology physical functioning Prognosis Quality of Life Resistance Training - methods Self Report Sex Factors Statistics, Nonparametric Treatment Outcome |
| title | Patient‐reported outcomes, body composition, and nutrition status in patients with head and neck cancer: Results from an exploratory randomized controlled exercise trial |
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