Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity
Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7–Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7–Hsp70 complex, which is ac...
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| Veröffentlicht in: | Doklady. Biological sciences 2017, Vol.472 (1), p.31-33 |
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| container_title | Doklady. Biological sciences |
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| creator | Romanova, E. A. Dukhanina, E. A. Sharapova, T. N. Sashchenko, L. P. Gnuchev, N. V. Yashin, D. V. |
| description | Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7–Mts1 and can migrate along the gradient of its concentration. After activation of these cells by IL-2, they acquire the abilities to kill tumor cells and to release the cytotoxic Tag7–Hsp70 complex, which is accompanied by a loss of both the Tag7–Mts1-mediated lymphocyte chemotaxis and the ability to release this chemoattractant into the conditioned medium. |
| doi_str_mv | 10.1134/S0012496617010094 |
| format | Article |
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| subjects | Biomedical and Life Sciences Cell Biology Chemotaxis - immunology Cyclin-Dependent Kinase Inhibitor p16 - immunology Cytokines - immunology Evolutionary Biology Humans Immunity, Cellular Interleukin-2 - immunology K562 Cells Life Sciences Lymphocyte Activation Lymphocytes - immunology Neoplasms - immunology Plant Sciences |
| title | Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity |
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