Effect of Adjuvant Radiotherapy on Survival in Patients with Locoregional Urothelial Malignancies of the Upper Urinary Tract

While radical nephroureterectomy is the treatment of choice for localized or regional urothelial carcinoma of the upper urinary tract (UTUC), the role of adjuvant radiotherapy is unclear, with conflicting data from various small studies. We sought to study the impact of adjuvant radiotherapy on UTUC...

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Veröffentlicht in:	Anticancer research 2016-08, Vol.36 (8), p.4051-4055
Hauptverfasser:	Hahn, Andrew W, Giri, Smith, Pathak, Ranjan, Bhatt, Vijaya Raj, Martin, Mike G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Disease-Free Survival Female Humans Male Middle Aged Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Radiotherapy, Adjuvant - adverse effects Radiotherapy, Adjuvant - methods Urinary Bladder Neoplasms - epidemiology Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - radiotherapy Urothelium - pathology Urothelium - radiation effects
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Zusammenfassung:	While radical nephroureterectomy is the treatment of choice for localized or regional urothelial carcinoma of the upper urinary tract (UTUC), the role of adjuvant radiotherapy is unclear, with conflicting data from various small studies. We sought to study the impact of adjuvant radiotherapy on UTUC by utilizing the Survelliance, Epidemiolgy, and End Results (SEER) 9 database from 1998-2011. Of 2,572 identified cases, 113 patients (4.4%) received adjuvant radiotherapy, with a median age of 74 years (range=22-100 years). In univariate analysis, patients treated with adjuvant radiation therapy seemed to have a lower survival time than those without radiation therapy (19 months versus 31 months, p
ISSN:	0250-7005 1791-7530