Management of Metastatic Bone Disease Algorithms for Diagnostics and Treatment

Bone is a frequent site of metastases in advanced cancer and is associated with significant skeletal morbidity. Current treatment options are aimed at preserving and improving functional independence and quality of life. A review of current literature focusing on diagnostic tools and treatment appro...

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Veröffentlicht in:	Anticancer research 2016-06, Vol.36 (6), p.2631-2637
Hauptverfasser:	Jehn, Christian F, Diel, Ingo J, Overkamp, Friedrich, Kurth, Andreas, Schaefer, Reinhold, Miller, Kurt, Lüftner, Diana
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bone Neoplasms - diagnosis Bone Neoplasms - pathology Bone Neoplasms - therapy Humans Neoplasm Metastasis
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creator	Jehn, Christian F Diel, Ingo J Overkamp, Friedrich Kurth, Andreas Schaefer, Reinhold Miller, Kurt Lüftner, Diana
description	Bone is a frequent site of metastases in advanced cancer and is associated with significant skeletal morbidity. Current treatment options are aimed at preserving and improving functional independence and quality of life. A review of current literature focusing on diagnostic tools and treatment approaches of bone metastasis in advanced cancer was performed and conclusions were incorporated into diagnostic and treatment algorithms. Radiologic imaging has added valuable tools for screening and diagnostics of bone metastasis. Clinical management of skeletal metastasis includes improved pain management, introduction of bone modifying agents and advancements in surgical and radiation therapy. We propose three algorithms enhancing the sensitivity of diagnostics and improving multidisciplinary management of vertebral and non-vertebral bone metastasis. Bone metastases are an expression of a systemic disease. Treatment options include highly specialized modalities yet need to be tailored to individual needs. Algorithms help standardize treatment procedures and can improve treatment outcome in a multidisciplinary setting.
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subjects	Algorithms Bone Neoplasms - diagnosis Bone Neoplasms - pathology Bone Neoplasms - therapy Humans Neoplasm Metastasis
title	Management of Metastatic Bone Disease Algorithms for Diagnostics and Treatment
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